北京大学学报(医学版) ›› 2018, Vol. 50 ›› Issue (6): 1098-1101. doi: 10.19723/j.issn.1671-167X.2018.06.028
Lei LIU(),Li-hua WANG,Yu-bo REN,Xiao-song RAO,Shao-min YANG
摘要:
侵袭性血管黏液瘤是一种少见的间叶性肿瘤,为探讨其临床病理学特征、诊治及预后,本研究收集北京大学国际医院4例盆腹腔软组织侵袭性血管黏液瘤的临床影像资料,分析其病理学形态、免疫表型及治疗随访情况,并回顾相关文献。本组4例均为女性,年龄27~49岁,平均年龄33岁,无诱因腹胀或无明显不适经体检发现,3例原发、1例复发。3例CT及磁共振扫描可见分层/漩涡征。肿瘤主体均位于盆腔,1例同时累及腹腔。肿瘤最大径5~22 cm,切面灰白、灰黄色,实性,质软,灶性水肿或囊性改变。显微镜下瘤细胞短梭形,异型不明显,间质富疏松水肿黏液或胶原,有丰富的薄壁及厚壁血管,部分血管壁玻璃样变性。肿瘤可浸润周围脂肪、神经组织。免疫组织化学染色提示4例肿瘤均雌激素受体、孕激素受体、结蛋白、平滑肌肌动蛋白弥漫阳性,CD34仅血管表达,S-100蛋白、CD117、Dog1均阴性。手术完整切除肿瘤,术后随访有1例二次复发。侵袭性血管黏液瘤确诊以病理形态学为基础,辅以免疫组织化学进一步诊断及鉴别诊断;手术切除后可多次复发。
中图分类号:
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