北京大学学报(医学版) ›› 2021, Vol. 53 ›› Issue (3): 623-627. doi: 10.19723/j.issn.1671-167X.2021.03.031

• 综述 • 上一篇    下一篇

社交媒体数据在药品上市后安全性监测的应用

杨羽1,王胜锋2,詹思延2,Δ()   

  1. 1.北京大学健康医疗大数据国家研究院, 北京 100191
    2.北京大学公共卫生学院流行病学与卫生统计学系, 北京 100191
  • 收稿日期:2020-12-10 出版日期:2021-06-18 发布日期:2021-06-16
  • 通讯作者: 詹思延 E-mail:siyan-zhan@bjmu.edu.cn
  • 基金资助:
    国家重点研发计划项目(2018AAA0102100)

Utilizing social media data in post-market safety surveillance

YANG Yu1,WANG Sheng-feng2,ZHAN Si-yan2,Δ()   

  1. 1. National Institute of Health Data Science, Peking University, Beijing 100191, China
    2. Department of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, Chian
  • Received:2020-12-10 Online:2021-06-18 Published:2021-06-16
  • Contact: Si-yan ZHAN E-mail:siyan-zhan@bjmu.edu.cn
  • Supported by:
    National Key Research and Development Program of China(2018AAA0102100)

摘要:

关键词: 药品安全, 上市后监测, 社交媒体

Abstract:

Post-marketing surveillance is the principal means to ensure drug use safety. The spontaneous report is the essential method of post-marketing surveillance for drug safety. Often most spontaneous reports come from medical staff and sometimes come from patients who use the drug. The posts published by individuals on social media platforms that contain drugs and related adverse reaction content have gradually been seen as a new data source similar to spontaneous reports from drug users in recent years. Those user-generated posts potentially provide researchers and regulators with new opportunities to conduct post-marketing surveillance for drug safety from patients’ perspectives mostly rather than medical professionals and can afford the possibility theoretically to discover drug-related safety issues earlier than traditional methods. Social media data as a new data source for safety signal detection and signal reinforcement have the unique advantages, such as population coverage,type of drugs, type of adverse reactions, data timeliness and quantity. Most of the social media data used in post-marketing surveillance research for drug safety are still text data in English, and even multiple languages are used by different people worldwide on several social media platforms. Unfortunately, there is still a controversy in the academic circles whether social media data can be used as reliable data sources for routine post-marketing surveillance for drug safety. A couple of obstacles of data, methods and ethics must be overcome before leveraging social media data for post-marketing surveillance. The number of Chinese social media users is large, and the social media data in the Chinese language is rapidly snowballing, which can be employed as the potential data source for post-marketing surveillance for drug safety. However, due to the Chinese language’s specific characteristics, the text’s diversity is different from the English text, and there is not enough accepted corpus in medical scenarios. Besides, the lack of domestic laws and regulations on privacy and security protection of social media data poses more challenges for applying Chinese social media data for post-market surveillance. The significance of social media data to post-marketing surveillance for drug safety is undoubtedly significant. It will be an essential development direction for future research to overcome the challenges of using social media data by developing new technologies and establishing new mechanisms.

Key words: Drug safety, Post-marketing surveillance, Social media

中图分类号: 

  • R9
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