健康人口的颌面部定量躯体感觉功能数据及其影响因素分析

doi:10.3969/j.issn.1671-167X.2015.03.028

摘要/Abstract

摘要： 目的：通过系统的定量感觉测试初步建立健康汉族人性别、年龄、位点分层的口颌面部躯体感觉功能数据，研究性别、年龄和位点对口颌面部的躯体感觉功能的影响。方法：采用德国神经疼痛研究网络建立的定量感觉测试程序，包括7项机械、温度感觉测试，13个测试指标。70名健康志愿者分为两组：年轻组（女性16名，男性16名，年龄24~40岁）和年长组（女性20名，男性18名，年龄41~69岁）。通过对70名志愿者6个位点的测试（双侧眶下、颏部和手部），评价性别，年龄，位点和左、右侧对躯体感觉功能的影响。结果：70名汉族人性别、年龄、位点分层的11项定量感觉测试数据表明，女性在大多数测试项目上比男性敏感（P<0.05）。年轻组与年长组相比，在大多数感觉参数上差异均有统计学意义（P<0.05），年轻组较年长组更敏感（P<0.01）的感觉参数有：热痛阈值：年轻组(38.07±2.94) ℃、年长组(39.85±3.52) ℃，温感知阈值：年轻组（1.40±0.74） ℃、年长组（1.89±1.14） ℃，触觉阈值：年轻组(0.73±1.66) mN、年长组(1.41±2.82) mN，压痛阈值：年轻组(171.71±92.51) kPa、年长组(196.36±73.73) kPa，冷痛阈值：年轻组(25.90±5.38) ℃、年长组(21.64±6.78) ℃，冷感知阈值：年轻组（-0.97±0.55）℃、年长组（-1.36±0.90） ℃，叠加效应：年轻组3.33±2.20、年长组2.67±1.68。然而两组相比，年长组较年轻组更敏感（P<0.05）的感觉参数有：力疼痛阈值：年轻组(111.50±88.93) mN、年长组(104.49±94.94) mN，力刺激评分：年轻组6.96±5.61、年长组8.93±6.53，振动阈值：年轻组(7.44±0.52) scale、年长组(7.55±0.48) scale。身体不同部位的感觉功能有差异，对于冷感知阈值、热痛阈值、温感知阈值、温度感觉阈、触觉阈值、力疼痛阈值、力疼痛敏感性评分、压痛阈值测试指标来说，面部的感觉敏感性高于手部（P<0.001），而对于振动感知阈值来说，手部较面部敏感（P<0.001）。结论：通过对健康汉族人系统的定量感觉测试，初步建立了汉族人性别、年龄、位点分层的躯体感觉功能数据，评价了性别、年龄、位点对躯体感觉功能的影响。

关键词: 定量感觉测试, 躯体感觉功能, 性别因素, 年龄因素

Abstract: Objective： To establish the preliminary somatosensory data stratified by gender, age group, and sites in the trigeminal region through standardized quantitative sensory testing on healthy individuals, and to evaluate the effects of gender, age, and sites on somatosensory functions. Methods: The standardised QST battery developed by the German Research Network on Neuropathic Pain consists totally of 13 different parameters. A total of 70 healthy individuals participated. The subjects were stratified into two groups according to age: younger group (16 female, 16 male, age 24-40 years old) and elder group (20 female, 18 male, age 41-69 years old). The test was performed bilaterally over the infraorbital, mental, and hand regions. Results: The preliminary orofacial somatosensory data stratified by gender, age group, and sites were presented. Female were more sensitive than male for most of the parameters (P<0.05). Age had a significant effect on most of the parameters (P<0.05), the younger group was more sensitive compared with the elder group (P<0.01) for heat pain threshold (HPT): younger group (38.07±2.94) ℃, elder group (39.85±3.52) ℃; warmth detection threshold (WDT): younger group (1.40±0.74) ℃, elder group (1.89±1.14) ℃; mechanical detection threshold (MDT): younger group (0.73±1.66) mN, elder group (1.41±2.82) mN; pressure pain threshold (PPT): younger group (171.71±92.51) kPa, elder group (196.36±73.73) kPa; cold pain threshold (CPT): younger group (25.90±5.38) ℃, elder group (21.64±6.78) ℃; cold detection threshold (CDT): younger group (-0.97±0.55) ℃, elder group (-1.36±0.90) ℃, and windup ratio (WUR): younger group (3.33±2.20), elder group (2.67±1.68). The inverse results were demonstrated for mechanical pain threshold (MPT): younger group (111.50±88.93) mN, elder group (104.49±94.94) mN; mechanical pain sensitivity (MPS): younger group (6.96±5.61), elder group (8.93±6.53), and vibration detection threshold (VDT): younger group (7.44±0.52) scale, elder group (7.55±0.48) scale (P<0.05). Somatosensory function was site dependent (P<0.001), the two trigeminal sites (infraorbital and mental) were more sensitive than the hand for CDT, HPT, WDT, thermal sensory limen (TSL), MDT, MPT, MPS, and PPT (P<0.001), but the inverse result was observed for VDT (P<0.001). Conclusion: The preliminary orofacial somatosensory data of Han Ethnicity stratified by gender, age group, and sites were established. The study evaluated the effects of gender, age and sites on orofacial somatosensory functions by employment standardized quantitative sensory testing.

Key words: Quantitative sensory testing, Somatosensory function, Sex factors, Age factors

中图分类号:

R339.1

杨广聚, 曹烨, 张磊, 秦雪英, 谢秋菲. 健康人口的颌面部定量躯体感觉功能数据及其影响因素分析[J]. 北京大学学报（医学版）, 2015, 47(3): 521-528.

YANG Guang-Ju, CAO Ye, ZHANG Lei, QIN Xue-Ying, XIE Qiu-Fei. Data of the quantitative orofacial somatosensory functions of healthy subjects and its influence factors analysis[J]. Journal of Peking University(Health Sciences), 2015, 47(3): 521-528.

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