FADS1 rs174537基因多态性与侵袭性牙周炎患者血清蛋白的相关性

doi:10.3969/j.issn.1671-167X.2016.01.003

摘要/Abstract

摘要：

目的：探讨FADS1 rs174537基因多态性与侵袭性牙周炎患者血清蛋白的相关性，为侵袭性牙周炎的诊断和治疗提供一定的理论基础。方法：选择353名侵袭性牙周炎患者（AgP组）和125名健康对照者（HP组）进行FADS1 rs174537位点基因型和血清生化指标的检测，比较分析不同FADS1 rs174537基因型患者的血清总蛋白（total protein ,TP）、球蛋白（globulin，GLB）、白蛋白（albumin，ALB）、白球比（albumin/globulin，A/G）。结果：（1）AgP组FADS1 rs174537位点G等位基因检出率显著高于HP组（68.1% vs. 61.2%, P=0.046，OR=1.35，95%可信区间为1.00~1.83）；AgP组FADS1 rs174537位点GG基因型的检出率显著高于HP组（45.5% vs.34.4%， P=0.029，OR=1.60，95%可信区间为1.05~2.44）；（2）AgP组GG基因型患者的TP、GLB水平显著低于GT+TT基因型患者［TP (77.08±7.88) g/L vs. (79.00±4.66) g/L，P=0.007；GLB (28.17±7.63) g/L vs. (29.88±3.49) g/L，P=0.007］，A/G则显著高于GT+TT基因型患者（1.72±0.22 vs.1.67±0.22，P=0.040），而ALB水平差异没有统计学意义（P>0.05）， HP组不同基因型者的TP、GLB、A/G及ALB差异均无统计学意义（P>0.05）；（3）AgP组GT+TT基因型患者的TP、GLB较相同基因型的健康受试者显著升高［TP (79.00±4.66) g/L vs. (75.20 ±4.53) g/L, P<0.01；GLB (29.88±3.49) g/L vs.(26.55±2.94) g/L, P<0.01］， A/G更低水平（1.67±0.22 vs. 1.88±0.30, P<0.01），差异具有统计学意义, 而ALB水平差异无统计学意义（P>0.05）；AgP组GG基因型患者与HP组GG基因型者相比，TP、GLB、A/G及ALB差异均无统计学意义（P>0.05）。结论： FADS1 rs174537位点与侵袭性牙周炎的易感性密切相关，在侵袭性牙周炎患者中，该位点GG基因型与低TP、GLB、高A/G有关；FADS1 rs174537位点的GG基因型可能通过降低牙周防御机能，促进炎症反应，从而成为侵袭性牙周炎的重要危险因素之一。

关键词: 侵袭性牙周炎, 球蛋白类, 脂肪酸去饱和酶类, 多态现象, 遗传

Abstract:

Objective：To investigate the potential association between FADS1 rs174537 polymorphism and serum proteins in patients with aggressive periodontitis， which may provide benefits for diagnosis and treatment of aggressive periodontitis. Methods: A total of 353 patients with aggressive periodontitis (group AgP) and 125 matched controls (group HP) were recruited in the study．Genotyping of FADS1 rs174537 and serum biochemical indexes were tested at the study’s start. The relationships between the levels of TP, GLB, ALB, A/G and genotyping were analyzed. Results: （1）The detection rate of allele G in group AgP was higher than that in group HP（68.1% vs. 61.2%, P=0.046，OR=1.35，95% CI 1.00－1.83）; the detection rate of genotype GG in group AgP was higher than in group HP（45.5% vs. 34.4%，P=0.029, OR=1.60, 95% CI 1.05－2.44）. (2) In group AgP, the patients with GG genotype exhibited significantly lower TP, GLB than the patients with GT+TT genotype ［(77.08±7.88) g/L vs. (79.00±4.66) g/L， P=0.007；(28.17±7.63) g/L vs.(29.88±3.49) g/L，P=0.007） and the higher A/G（1.72±0.22 vs.1.67±0.22, P=0.040）, but there was no significant difference in ALB between the patients with GG genotype and the patients with GT+TT genotype. In group HP, there were no significant differences in TP, GLB, A/G and ALB between individuals with genotype GT+TT and with genotype GG. (3)Compared with individuals with genotype GT+TT in group HP, the AgP patients with genotype GT+TT exhibited significantly higher TP, GLB ［(79.00±4.66) g/L vs. (75.20±4.53) g/L, P<0.01; (29.88±3.49) g/L vs.(26.55±2.94) g/L, P<0.01）and the lo-wer A/G（1.67±0.22 vs. 1.88±0.30, P<0.01）, but there was no significant difference in ALB. There were no significant differences in TP, GLB, A/G and ALB the between the AgP patients with ge-notype GG and the healthy subjects with the same genotype either.Conclusion: FADS1 rs174537 polymorphism is associated with aggressive periodontitis. The patients with genotype GG in group AgP had relatively lower TP，GLB and higher A/G. Genotype GG might be a risk indicator for aggressive periodontitis by reducing host defense capability and contributing to inflammatory response in the occurrence and development of aggressive periodontitis.

Key words: Aggressive periodontitis, Globulins, Fattyacid desaturases, Polymorphism, genetic

中图分类号:

R781.42

宋文莉，田雨，王宪娥，张立，徐莉，释栋，冯向辉，路瑞芳，陈智滨，孟焕新. FADS1 rs174537基因多态性与侵袭性牙周炎患者血清蛋白的相关性[J]. 北京大学学报(医学版), 2016, 48(1): 10-15.

SONG Wen-li, TIAN Yu, WANG Xian-e, ZHANG Li, XU Li, SHI Dong, FENG Xiang-hui, LU Rui-fang, CHEN Zhi-bin, MENG Huan-xin. Association between FADS1 rs174537 polymorphism and serum proteins in patients with aggressive periodontitis[J]. Journal of Peking University(Health Sciences), 2016, 48(1): 10-15.

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