北京大学学报(医学版) ›› 2018, Vol. 50 ›› Issue (1): 26-32. doi: 10.3969/j.issn.1671-167X.2018.01.005

• 论著 • 上一篇    下一篇

乏氧诱导因子-1α在口腔鳞状细胞癌颈淋巴转移中的作用

李健男1,冯芝恩2,王琳3,王衣祥3,郭传瑸3△   

  1. (1. 北京大学口腔医学院·口腔医院,综合科口腔数字化医疗技术和材料国家工程实验室口腔数字医学北京市重点实验室, 北京100081;2.首都医科大学附属北京口腔医院口腔颌面头颈肿瘤科, 北京100050;3. 北京大学口腔医学院·口腔医院口腔颌面外科, 北京100081)
  • 出版日期:2018-02-18 发布日期:2018-02-18
  • 通讯作者: 郭传瑸 E-mail:guodazuo@sina.com
  • 基金资助:
    国家自然科学基金(81470707)资助

Expression of hypoxiainducible factor 1α is associated with lymph node metastasis in oral squamous cell carcinoma

LI Jian-nan1, FENG Zhi-en2, WANG Lin3, WANG Yi-xiang3, GUO Chuan-bin3△   

  1. (1. Department of General Dentistry, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China; 2. Department of Oral and MaxillofacialHead and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, China; 3. Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China)
  • Online:2018-02-18 Published:2018-02-18
  • Contact: GUO Chuan-bin E-mail:guodazuo@sina.com
  • Supported by:
    Supported by the National Natural Science Foundation of China (81470707)

摘要: 目的:探讨乏氧诱导因子-1α(hypoxia-inducible factor 1α,HIF-1α)蛋白表达在口腔鳞状细胞癌颈淋巴转移中的作用及其在判断预后方面的意义。方法:1993年6月至2010年5月在北京大学口腔医院住院并接受手术治疗的原发口腔鳞状细胞癌患者125例纳入本次研究,收集所有患者的临床病理学资料,制作组织病理切片,应用免疫组织化学方法检测HIF-1α蛋白的表达情况,根据表达情况分为高表达组和低表达组,主要评估指标为颈淋巴转移率和癌相关生存率(disease-specific survival,DSS)。颈淋巴转移率与各项临床病理学参数的关系比较采用秩和检验,组间及组内癌相关生存率的差异性比较采用Kaplan-Meier分析,并应用COX多因素生存分析对DSS的独立预测因子进行统计分析。所有统计学分析均采用SPSS 17.0软件包完成。结果:随访截止日期为2013年6月1日,生存患者的中位随访时间为73个月,有75例HIF-1α高表达,48例HIF1α低表达,2例无法评估。秩和检验分析发现,HIF-1α高表达组淋巴转移率显著高于HIF-1α低表达组(58.7% vs. 37.5%,P=0.027)。Kaplan-Meier生存分析发现,HIF-1α低表达组患者无病生存率显著高于高表达组(60.4% vs. 36.0%,P=0.009), 癌相关生存率显著高于高表达组(70.8% vs. 46.7%,P=0.005)。多因素生存分析表明,HIF-1α表达(HR=2.164,95%CI:1.150~4.074,P=0.017)和T分期(HR=1.387,95%CI:1.066~1.804,P=0.015)均是判断口腔鳞状细胞癌患者预后的独立预测因子。结论:HIF-1α蛋白表达是预测口腔鳞状细胞癌预后的独立因子,且与颈淋巴转移显著相关,能够作为口腔鳞状细胞癌潜在的分子诊断标志物和靶向治疗靶点。

关键词: 乏氧诱导因子1α, 癌, 鳞状细胞, 头颈部肿瘤, 淋巴转移, 预后

Abstract: Objective: To explore the association between hypoxia-inducible factor 1α (HIF-1α) expression and lymph node metastasis in oral squamous cell carcinoma (OSCC). Methods: Tumor specimens from 125 patients with histologically-proven, surgically-treated OSCC were examined by immunohistochemical staining for expression of HIF-1α. The patients were divided into two groups by the expression of HIF-1α, high expression of HIF-1α group (H-group) and low expression of HIF-1α group (L-group). The main assessment parameters were lymph node metastasis rate and disease-specific survival (DSS). The lymph node metastasis rate and clinicopathologic features were compared using Mann-Whitney test. The Kaplan-Meier curve was generated for each group and compared using the log-rank test. Cox proportional hazard models were utilized for multivariate analyses of HIF-1α expression and other baseline factors with DSS. All calculations and analyses were performed using the SPSS 17.0 software package. Results: The protein expression levels of HIF-1α were up-regulated in OSCC and two patients were unable to evaluate. There were 48 patients in L-group and 75 patients in H-group. Lymph node metastasis rate was 37.5% (18/48) for L-group and 58.7% (44/75) for H-group (P=0.027). Expression of HIF-1α was significantly correlated with lymph node metastasis. The patients of L-group had a significantly better DSS than the patients of Hgroup (70.8% vs. 46.7%, P=0.005), while the patients of L-group had a significantly better disease-free survival (DFS ) than the patients of H-group (60.4% vs. 36.0%, P=0.009) by Kaplan-Meier method. A multivariate survival analysis also showed that HIF-1α expression (HR=2.164, 95%CI: 1.150-4.074, P=0.017) and Tstage (HR=1.387, 95%CI: 1.066-1.804, P=0.015) both were the independent factors associated with prognosis. Conclusion: HIF-1α expression is significantly correlated with lymph node metastasis in OSCC. HIF-1α expression is an independent predictive factor for prognosis of OSCC patients, and may serve as a potential biomarker for molecular diagnosis and targeted therapy in future.

Key words: Hypoxia-inducible factor 1α, Carcinoma, squamous cell, Head and neck neoplasms, Lymphatic metastasis, Prognosis

中图分类号: 

  • R739.8
[1] 周传香,周正,张晔,刘晓筱,高岩. 28例口腔基底样鳞状细胞癌的临床病理分析[J]. 北京大学学报(医学版), 2022, 54(1): 62-67.
[2] 苏俊琪,宋扬,谢尚. 口腔鳞状细胞癌患者修复重建术后感染的病原学特征及感染风险预测模型的构建[J]. 北京大学学报(医学版), 2022, 54(1): 68-76.
[3] 穆东亮,薛铖,安彬,王东信. 硬膜外阻滞与结直肠癌患者术后远期生存状态的关系:一项倾向性评分匹配的回顾性研究[J]. 北京大学学报(医学版), 2021, 53(6): 1152-1158.
[4] 王飞,朱翔,贺蓓,朱红,沈宁. 自发缓解的滤泡性细支气管炎伴非特异性间质性肺炎1例报道并文献复习[J]. 北京大学学报(医学版), 2021, 53(6): 1196-1200.
[5] 高伟波,石茂静,张海燕,吴春波,朱继红. 显著高铁蛋白血症与噬血细胞性淋巴组织细胞增多症的相互关系[J]. 北京大学学报(医学版), 2021, 53(5): 921-927.
[6] 张梅香,史文芝,刘建新,王春键,李燕,王蔚,江滨. MLL-AF6融合基因阳性急性髓系白血病的临床特征及预后[J]. 北京大学学报(医学版), 2021, 53(5): 915-920.
[7] 田雨,程晓悦,贺慧颖,王国良,马潞林. 肾细胞癌合并尿路瘤栓的临床病理特征: 6例报道及文献回顾[J]. 北京大学学报(医学版), 2021, 53(5): 928-932.
[8] 蒋艳芳,王健,王永健,刘佳,裴殷,刘晓鹏,敖英芳,马勇. 前交叉韧带翻修重建术后中长期临床疗效及影响因素[J]. 北京大学学报(医学版), 2021, 53(5): 857-863.
[9] 庞泳,张沙,杨华,周柔丽. LAPTM4B-35蛋白作为肝癌血清学诊断新标志物的探讨[J]. 北京大学学报(医学版), 2021, 53(4): 710-715.
[10] 肖若陶,刘承,徐楚潇,何为,马潞林. 术前血小板参数与局部进展期肾细胞癌预后[J]. 北京大学学报(医学版), 2021, 53(4): 647-652.
[11] 白杲琛,宋毅,金杰,虞巍,何志嵩. 多西他赛联合卡铂治疗转移性去势抵抗性前列腺癌的临床疗效[J]. 北京大学学报(医学版), 2021, 53(4): 686-691.
[12] 于妍斐,何世明,吴宇财,熊盛炜,沈棋,李妍妍,杨风,何群,李学松. 延胡索酸水合酶缺陷型肾细胞癌的临床病理特征及预后[J]. 北京大学学报(医学版), 2021, 53(4): 640-646.
[13] 孙争辉,黄晓娟,董靖晗,刘茁,颜野,刘承,马潞林. 临床T1期肾细胞癌肾窦侵犯的危险因素[J]. 北京大学学报(医学版), 2021, 53(4): 659-664.
[14] 赵勋,颜野,黄晓娟,董靖晗,刘茁,张洪宪,刘承,马潞林. 癌栓粘连血管壁对非转移性肾细胞癌合并下腔静脉癌栓患者手术及预后的影响[J]. 北京大学学报(医学版), 2021, 53(4): 665-670.
[15] 韩松辰,黄子雄,刘慧鑫,徐涛. 单侧肾细胞癌根治性切除术后的肾功能代偿[J]. 北京大学学报(医学版), 2021, 53(4): 680-685.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] 张三. 中文标题测试[J]. 北京大学学报(医学版), 2010, 42(1): 1 -10 .
[2] 赵磊, 王天龙 . 右心室舒张末期容量监测用于肝移植术中容量管理的临床研究[J]. 北京大学学报(医学版), 2009, 41(2): 188 -191 .
[3] 万有, , 韩济生, John E. Pintar. 孤啡肽基因敲除小鼠电针镇痛作用增强[J]. 北京大学学报(医学版), 2009, 41(3): 376 -379 .
[4] 张燕, 韩志慧, 钟延丰, 王盛兰, 李玲玲, 郑丹枫. 骨骼肌活组织检查病理诊断技术的改进及应用[J]. 北京大学学报(医学版), 2009, 41(4): 459 -462 .
[5] 赵奇, 薛世华, 刘志勇, 吴凌云. 同向施压测定自酸蚀与全酸蚀粘接系统粘接强度[J]. 北京大学学报(医学版), 2010, 42(1): 82 -84 .
[6] 林红, 王玉凤, 吴野平. 学校生活技能教育对小学三年级学生行为问题影响的对照研究[J]. 北京大学学报(医学版), 2007, 39(3): 319 -322 .
[7] 丰雷, 程嘉, 王玉凤. 注意缺陷多动障碍儿童的运动协调功能[J]. 北京大学学报(医学版), 2007, 39(3): 333 -336 .
[8] 李岳玲, 钱秋瑾, 王玉凤. 儿童注意缺陷多动障碍成人期预后及其预测因素[J]. 北京大学学报(医学版), 2007, 39(3): 337 -340 .
[9] . 书讯[J]. 北京大学学报(医学版), 2007, 39(3): 225 -328 .
[10] 牟向东, 王广发, 刁小莉, 阙呈立. 肺黏膜相关淋巴组织型边缘区B细胞淋巴瘤一例[J]. 北京大学学报(医学版), 2007, 39(4): 346 -350 .