核转出蛋白对前列腺癌雄激素受体稳定性的调节

巩艳青^△, 张崔建, 何世明, 李学松, 周利群, 郭应禄

Nuclear export signal of androgen receptor regulated of androgen receptor stability in prostate cancer

GONG Yan-qing^△, ZHANG Cui-jian, HE Shi-ming, LI Xue-song, ZhOU Li-qun, GUO Ying-lu

含NES^AR的融合蛋白具有降解不稳定性 Fusion proteins containing NES^AR are not stable in the presence of cycloheximide. PC3 cells were transfected with GFP and GFP-NES^AR(A), GFP-NAR (1-665aa) and GFP-NAR-NES^AR(B) respectively. 20 h later, cells were treated with 50 mg/L CHX for indicated time points. Protein expression was examined by Western blot with anti-GFP antibody.