核转出蛋白对前列腺癌雄激素受体稳定性的调节 |
巩艳青 , 张崔建, 何世明, 李学松, 周利群, 郭应禄 |
Nuclear export signal of androgen receptor regulated of androgen receptor stability in prostate cancer |
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GONG Yan-qing
, ZHANG Cui-jian, HE Shi-ming, LI Xue-song, ZhOU Li-qun, GUO Ying-lu |
| NESAR的降解依赖于蛋白酶体途径 A&B, proteasome inhibition increases the level of NESAR containing fusion proteins, transfeced PC3 cells were incubated overnight and then treated with vehicle or different concentrations of MG132 for 24 h. C&D, NESAR fusion proteins’ degradation was blocked by proteasome inhibitor in the presence of cycloheximide, transfeced PC3 cells were incubated overnight and then treated with vehicle or 50 mg/L CHX plus different concentrations of MG132 for 24 h. Protein expression was examined by Western blot with anti-GFP antibody. |
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