基于4-氨基-5-甲酰基-8,10-二去氮杂四氢叶酸二乙酯侧链的水解反应条件优化

袁蒙蒙¹, 王锰¹, 刘俊义^1,², 张志丽^1,^△

Optimization of alkaline hydrolysis based on the side chain of diethyl ester 4-amino-N⁵ -formyl-N⁸,N¹⁰ -dideazatetrahydrofolic acid

YUAN Meng-meng¹, WANG Meng¹, LIU Jun-yi^1,², ZHANG Zhi-li^1,^△

不同反应条件下4-氨基-5-甲酰基-8,10-二去氮杂四氢叶酸二乙酯水解的高效液相监测色谱图 A,hydrolysis reaction in 0.3 mol/L KOH for 60 min;B,hydrolysis reaction in 0.3 mol/L NaOH for 120 min;C,hydrolysis reaction in 1 mol/L KOH for 60 min.