非天然氨基酸定点偶联抗人类表皮生长因子受体2-抗体偶联药物的药理学活性

梁学军,宫丽颖,周菲,周德敏,祝静静

Pharmacological effects of site specific conjugated anti-human epidermal growth factor receptor 2-antibody drug conjugate using unnatural amino acid technology

Xue-jun LIANG,Li-ying GONG,Fei ZHOU,De-min ZHOU,Jing-jing ZHU

图1 抗HER2单克隆抗体和毒素AS269的定点偶联示意图

Figure 1 Site specific conjugate anti-HER2 mAb and cytotoxic AS269 HER2, human epidermal growth factor receptor 2; mAb, monoclonal antibody.