中国人群遗传性周围神经病的致病基因分布

刘小璇,段晓慧,张朔,孙阿萍,张英爽,樊东升

Genetic distribution in Chinese patients with hereditary peripheral neuropathy

Xiao-xuan LIU,Xiao-hui DUAN,Shuo ZHANG,A-ping SUN,Ying-shuang ZHANG,Dong-sheng FAN

图2 CMT1A患者的神经活检

Figure 2 Sural nerve biopsy in a patient with CMT1A A, the number of normal myelinated nerve fibers is reduced, and some myelin are lost and regenerated, showing a typical "onion" like structure (thin arrow), and occasionally regenerative cluster like structure (thick arrow, semi-thin sections, toluidine blue staining ×200); B, the concentric round collagen layer structure formed by Schwann cell proliferation, namely the "onion" structure (electron micrography). CMT, Charcot-Marie-Tooth.