抗Jo-1抗体在特发性炎性肌病临床分层及疾病谱中的意义

李嘉辰,赖展鸿,邵苗,金月波,高小娟,张科,侯儆,张燕英,栗占国,李玉慧

Significance of anti-Jo-1 antibody's clinical stratification in idiopathic inflammatory myopathy and disease spectrum

Jia-chen LI,Zhan-hong LAI,Miao SHAO,Yue-bo JIN,Xiao-juan GAO,Ke ZHANG,Jing HOU,Yan-ying ZHANG,Zhan-guo LI,Yu-hui LI

表1 抗Jo-1抗体阳性与阴性ASS患者临床特征及实验室数据对比

Table 1 Comparison of clinical features and laboratory data in ASS with positive and negative anti-Jo-1 antibody

Items Anti-Jo-1 (+) (n=84) Anti-Jo-1 (-) (n=45) t/Z/χ2 P Clinical features   Age of onset/years 49.9±12.8 55.0±11.9 2.247 0.026   Female 64 (76.2) 33 (73.3) 0.128 0.720   ILD 72 (85.7) 43 (95.6) 2.933 0.087   Arthritis 51 (60.7) 15 (33.3) 8.792 0.003   Myalgia 40 (47.1) 10 (22.2) 7.962 0.005   Myasthenia 45 (53.6) 21 (46.7) 0.559 0.455   Dysphagia 5 (6.0) 6 (13.3) 2.047 0.153   Mechanic hands 45 (53.6) 23 (51.1) 0.071 0.790   Gottron sign 68 (81.0) 39 (86.7) 0.676 0.411   Raynaud phenomenon 11 (13.1) 8 (17.8) 0.842 0.474   Neurologic abnormality 4 (4.8) 0 0.297a   Malignancy 2 (2.4) 1 (2.2) >0.999a Laboratory data   ANA+ 44 (52.4) 29 (64.4) 1.736 0.188   Anti-Ro-52 (+) 63 (75.0) 36 (80.0) 0.410 0.522   Anti-PM-Scl 75/100 (+) 5 (6.0) 0 0.156a   Anti-Mi-2 (+) 2 (2.4) 1 (2.2) >0.999a   Anti-SAE (+) 1 (1.2) 0 >0.999a   Anti-MDA5 (+) 1 (1.2) 0 >0.999a   Anti-NXP2 (+) 0 0   Anti-TIF-1γ (+) 0 1 (2.2) 0.349a   Anti-SRP (+) 1 (1.2) 0 >0.999a   ESR/(mm/h) 20.0 (8.0, 44.0) 32.0 (16.0, 58.0) -2.067 0.039   Elevated ESR 42 (50.0) 32 (71.1) 5.340 0.021   CRP/(mg/L) 4.3 (0.6, 27.0) 13.2 (1.5, 27.0) -1.648 0.099   Elevated CRP 51 (60.7) 24 (53.3) 0.656 0.418   CK/(U/L) 230.0 (93.0, 1 059.0) 131.0 (69.0, 413.0) -1.733 0.083   Elevated CK 46 (54.8) 19 (42.2) 1.843 0.175