抗Jo-1抗体在特发性炎性肌病临床分层及疾病谱中的意义

李嘉辰,赖展鸿,邵苗,金月波,高小娟,张科,侯儆,张燕英,栗占国,李玉慧

Significance of anti-Jo-1 antibody's clinical stratification in idiopathic inflammatory myopathy and disease spectrum

Jia-chen LI,Zhan-hong LAI,Miao SHAO,Yue-bo JIN,Xiao-juan GAO,Ke ZHANG,Jing HOU,Yan-ying ZHANG,Zhan-guo LI,Yu-hui LI

表2 抗Jo-1抗体滴度与ASS患者临床特征及实验室数据的相关性分析

Table 2 Correlation analysis between anti-Jo-1 antibody titer and clinical features and laboratory data of ASS patients

Items Anti-Jo-1 (+) (n=15) Anti-Jo-1 (++) (n=15) Anti-Jo-1 (+++)(n=54) r P Clinical features   Fever 5 (33.3) 4 (26.7) 9 (16.7) -0.163 0.140   ILD 12 (80.0) 13 (86.7) 47 (87.0) 0.062 0.576   Arthritis 4 (26.7) 7 (46.7) 40 (74.1) 0.385 < 0.001   Myalgia 6 (40.0) 11 (73.3) 24 (44.4) -0.071 0.521   Myasthenia 6 (40.0) 8 (53.3) 32 (59.3) 0.136 0.218   Dysphagia 0 0 5 (9.3) 0.183 0.096   Mechanic hands 4 (26.7) 8 (53.3) 33 (61.1) 0.233 0.033   Raynaud phenomenon 0 1 (2.6) 10 (15.2) 0.223 0.041   Gottron sign 9 (60.0) 12 (80.0) 47 (87.3) 0.236 0.031   Malignancy 1 (6.7) 0 1 (1.9) -0.074 0.504   Neurologic abnormality 1 (6.7) 0 3 (5.6) 0.028 0.797 Laboratory data   Elevated WBC 7 (46.7) 10 (66.7) 38 (70.4) 0.162 0.141   Decreased lymphocyte 8 (53.3) 9 (60.0) 31 (57.4) 0.016 0.887   Elevated neutrophil 10 (66.7) 11 (73.3) 38 (70.4) 0.013 0.905   Elevated ESR 7 (46.7) 4 (26.7) 31 (57.4) 0.159 0.151   Elevated CRP 7 (46.7) 1 (6.7) 24 (44.4) 0.087 0.445   Decreased albumin 13 (86.7) 10 (66.7) 40 (74.1) -0.058 0.600   Elevated CK 4 (26.7) 8 (53.3) 34 (63.0) 0.263 0.016   Elevated LDH 13 (86.7) 10 (66.7) 43 (79.6) 0.002 0.958   Elevated α-HBD 10 (66.7) 9 (60.0) 47 (87.0) 0.255 0.021