抗Jo-1抗体在特发性炎性肌病临床分层及疾病谱中的意义
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李嘉辰,赖展鸿,邵苗,金月波,高小娟,张科,侯儆,张燕英,栗占国,李玉慧
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Significance of anti-Jo-1 antibody's clinical stratification in idiopathic inflammatory myopathy and disease spectrum
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Jia-chen LI,Zhan-hong LAI,Miao SHAO,Yue-bo JIN,Xiao-juan GAO,Ke ZHANG,Jing HOU,Yan-ying ZHANG,Zhan-guo LI,Yu-hui LI
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表3 单一抗Jo-1抗体与抗Jo-1抗体合并其他MAAs/MSAs阳性ASS患者临床特征及实验室数据对比
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Table 3 Comparison of clinical features and laboratory data in ASS patients with positive anti-Jo-1 antibody only and ASS patients positive for anti-Jo-1 antibody combined with other MAAs/MSAs
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| Items | Isolated anti-Jo-1 (+)
(n=20) | Coexistence of anti-Jo-1 (+) and MAAs/MSAs (+)
(n=64) | t/Z/χ2 | P | | Clinical features | | | | | | Age of onset/years | 45.60±10.15 | 49.94±13.60 | -0.102 | 0.919 | | Female | 15 (75.0) | 49 (76.6) | < 0.001 | >0.999 | | Fever | 5 (25.0) | 13 (20.3) | 0.018 | 0.894 | | Myalgia | 5 (25.0) | 36 (56.3) | 5.956 | 0.015 | | Myasthenia | 7 (35.0) | 39 (61.0) | 4.138 | 0.042 | | Dysphagia | 0 | 5 (7.8) | | 0.332a | | Gottron sign | 15 (75.0) | 53 (82.8) | 0.203 | 0.652 | | Raynaud phenomenon | 2 (10.0) | 9 (14.1) | 0.008 | 0.928 | | ILD | 17 (85.0) | 55 (85.9) | < 0.001 | >0.999 | | Mechanic hands | 9 (45.0) | 36 (56.3) | 0.775 | 0.379 | | Arthritis | 11 (55.0) | 40 (62.5) | 0.359 | 0.549 | | Neurologic abnormality | 1 (5.0) | 3 (4.7) | | >0.999a | | Malignancy | 1 (5.0) | 1 (1.6) | | 0.422a | | Laboratory data | | | | | | ESR/(mm/h) | 15.5 (7.5, 31.5) | 22.0 (8.0, 56.0) | -1.076 | 0.282 | | Elevated ESR | 9 (45.0) | 33 (51.6) | 0.331 | 0.565 | | CRP/(mg/L) | 7.1 (0.5, 12.4) | 4.3 (0.6, 32.2) | -0.952 | 0.341 | | Elevated CRP | 8 (40.0) | 24 (37.5) | 0.046 | 0.836 | | CK/(U/L) | 155.0 (80.0, 756.0) | 237.0 (100.0, 1153.0) | -0.799 | 0.425 | | Elevated CK | 10 (50.0) | 36 (56.3) | 0.313 | 0.576 |
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