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Journal of Peking University (Health Sciences) ›› 2021, Vol. 53 ›› Issue (1): 227-231. doi: 10.19723/j.issn.1671-167X.2021.01.035

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  • Received:2019-08-01 Online:2021-02-18 Published:2021-02-07
  • Supported by:
    College Students Innovation Experiment Project of Peking University Health Science Center(BJMU-JC-2017202S)

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CLC Number: 

  • R96

Figure 1

Molecular structures of Tween 20, SDS and curcumin"

Figure 2

Curcumin standard curve"

Table 1

Solubilization of curcumin by compound surfactant"

Proportion of SDS CMC/(mmol/L) MSR R2
0% 0.11 0.025 3 0.989 6
40% 0.18 0.024 3 0.990 1
60% 0.27 0.011 9 0.988 0
80% 0.52 0.009 1 0.966 5

Figure 3

Solubilization of curcumin by compound surfactant"

Figure 4

UV spectrum of curcumin under pH=13"

Table 2

The protective effect of compound surfactant on curcumin"

Proportion of SDS CMC/(mmol/L) Pharmacokinetic equation k/min-1 R2
0% 0.11 lgC=-0.002 5t-1.691 2 0.005 8 0.999 5
20% 0.14 lgC=-0.002 0t-1.651 8 0.004 6 0.999 2
40% 0.18 lgC=-0.001 6t-1.699 4 0.003 7 0.999 7
60% 0.27 lgC=-0.001 2t-1.634 7 0.002 8 0.999 6
80% 0.52 lgC=-0.000 8t-1.626 3 0.001 8 0.991 1
100% 6.94 lgC=-0.001 1t-1.610 8 0.002 5 0.955 1
0%* lgC=-0.002 3t-1.113 2 0.005 3 0.980 5

Figure 5

UV spectrum of curcumin degradation products (0.05 mol/L)"

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