Journal of Peking University (Health Sciences) ›› 2023, Vol. 55 ›› Issue (3): 567-封三. doi: 10.19723/j.issn.1671-167X.2023.03.027

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The past, present and future of sleep medicine in China

Jia-hui DENG1,Xiao-lin HUANG1,Xiao-xing LIU1,Jie SUN2,Lin LU1,3,4,*()   

  1. 1. Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China
    2. Pain Medicine Center, Peking University Third Hospital, Beijing 100191, China
    3. Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China
    4. National Institute on Drug Dependence, Peking University & Beijing Key Laboratory of Drug Dependence Research, Beijing 100191, China
  • Received:2022-07-22 Online:2023-06-18 Published:2023-06-12
  • Contact: Lin LU E-mail:linlu@bjmu.edu.cn
  • Supported by:
    the National Natural Science Foundation of China(82271528)

Abstract:

Sleep is a highly conserved phenomenon in endotherms, and has a universal physiological function across all species. In mammals, sleep can be divided into two stages: rapid eye movement (REM) sleep and non-REM (NREM) sleep, which alternate in a cyclic manner. Humans spend about one-third of their lives asleep. Sufficient sleep is necessary for humans to sustain everyday functioning. Sleep plays an important role in regulating energy metabolism, immune defense, endocrine function, and the consolidation of memory process. With the development of social economy and the change of life style, sleep duration of the residents has gradually decreased and the incidence of sleep disturbances has increased. Sleep disturbances can lead to severe mental disorders, such as depression, anxiety disorders, dementia, and other mental diseases, and may increase the risk of physical diseases, such as chronic inflammation, heart disease, diabetes, hypertension, atherosclerosis and others. Maintaining good sleep is of great significance for developing social productive forces, promoting sustainable development of economic society, and is a necessary condition for carrying out the "Healthy China Strategy". The sleep research in China started in 1950s. After decades of development, researchers have made great progress in the molecular mechanisms of sleep and wakefulness, the pathogenesis of sleep disorders and the development of new therapies. With the advancement of science and technology and the public's attention to sleep, the level of clinical diagnosis and therapy of sleep disorders in China is gradually brought in line with international standards. The publication of diagnosis and treatment guidelines in the field of sleep medicine will promote the standardization of the construction. In the future, it is still necessary to promote the development of sleep medicine in the following aspects: Strengthening the professional training and discipline construction, improving the cooperation of sleep research, promoting the intelligent diagnosis and treatment of sleep disorders, and developing the new intervention strategies. Therefore, this review will comprehensively summarize the origin, current situation, and future expectations of sleep medicine in China, including discipline construction of sleep medicine, the number of sleep project grants, research findings, the status and progress of diagnosis and treatment of sleep disorders, and the development direction of sleep medicine.

Key words: Sleep medicine, Sleep disorders, China, Research progress

CLC Number: 

  • R338.63
1 Siegel JM . Sleep viewed as a state of adaptive inactivity[J]. Nat Rev Neurosci, 2009, 10 (10): 747- 753.
doi: 10.1038/nrn2697
2 Brandenberger G . Symposium: Normal and abnormal rem sleep regulation: Episodic hormone release in relation to REM sleep[J]. J Sleep Res, 1993, 2 (4): 193- 198.
doi: 10.1111/j.1365-2869.1993.tb00089.x
3 Rasch B , Born J . About sleep's role in memory[J]. Physiol Rev, 2013, 93 (2): 681- 766.
doi: 10.1152/physrev.00032.2012
4 Besedovsky L , Lange T , Haack M . The sleep-immune crosstalk in health and disease[J]. Physiol Rev, 2019, 99 (3): 1325- 1380.
doi: 10.1152/physrev.00010.2018
5 Jahrami HA , Alhaj OA , Humood AM , et al. Sleep disturbances during the COVID-19 pandemic: A systematic review, meta-analysis, and meta-regression[J]. Sleep Med Rev, 2022, 62, 101591.
doi: 10.1016/j.smrv.2022.101591
6 Shi L , Lu ZA , Que JY , et al. Prevalence of and risk factors associated with mental health symptoms among the general population in China during the coronavirus disease 2019 pandemic[J]. JAMA Netw Open, 2020, 3 (7): e2014053.
doi: 10.1001/jamanetworkopen.2020.14053
7 Streatfeild J , Smith J , Mansfield D , et al. The social and econo-mic cost of sleep disorders[J]. Sleep, 2021, 44 (11): zsab132.
doi: 10.1093/sleep/zsab132
8 Ge L , Guyatt G , Tian J , et al. Insomnia and risk of mortality from all-cause, cardiovascular disease, and cancer: Systematic review and meta-analysis of prospective cohort studies[J]. Sleep Med Rev, 2019, 48, 101215.
doi: 10.1016/j.smrv.2019.101215
9 Li L , Gan Y , Zhou X , et al. Insomnia and the risk of hypertension: A meta-analysis of prospective cohort studies[J]. Sleep Med Rev, 2021, 56, 101403.
doi: 10.1016/j.smrv.2020.101403
10 Hertenstein E , Feige B , Gmeiner T , et al. Insomnia as a predictor of mental disorders: A systematic review and meta-analysis[J]. Sleep Med Rev, 2019, 43, 96- 105.
doi: 10.1016/j.smrv.2018.10.006
11 健康中国行动推进委员会. 健康中国行动(2019—2030年)[EB/OL]. (2019-07-09)[2022-05-10]. http://www.gov.cn/xinwen/2019-07/15/content_5409694.htm.
12 刘艳骄, 孙书臣, 洪兰, 等. 中国睡眠医学的过去、现在与未来[J]. 世界睡眠医学杂志, 2014, 1 (1): 6- 11.
13 Karbowski K . Hans Berger (1873-1941)[J]. J Neurol, 2002, 249 (8): 1130- 1131.
doi: 10.1007/s00415-002-0872-4
14 万文鹏. 药物和睡眠[J]. 国际精神病学杂志, 1975, (3): 122- 126.
15 蔡浩然. 睡眠中什么时候做梦[J]. 科学大众, 1964, (6): 237.
16 Van Someren EJW . Brain mechanisms of insomnia: New perspectives on causes and consequences[J]. Physiol Rev, 2021, 101 (3): 995- 1046.
doi: 10.1152/physrev.00046.2019
17 Alonso-Fernandez A , Toledo-Pons N , Garcia-Rio F . Obstructive sleep apnea and venous thromboembolism: Overview of an emerging relationship[J]. Sleep Med Rev, 2020, 50, 101233.
doi: 10.1016/j.smrv.2019.101233
18 邓锐, 金鑫, 贾金忠, 等. 1988—2019年睡眠研究领域国家自然科学基金立项情况分析及未来展望[J]. 中国全科医学, 2022, 25 (14): 1687- 1693.
19 中华人民共和国科学技术部. 《科技部关于发布科技创新2030——"脑科学与类脑研究"重大项目2021年度项目申报指南的通知》[EB/OL]. (2021-09-16)[2022-05-25]. https://service.most.gov.cn/kjjh_tztg_all/20210916/4583.html.
20 Ren S , Wang Y , Yue F , et al. The paraventricular thalamus is a critical thalamic area for wakefulness[J]. Science, 2018, 362 (6413): 429- 434.
doi: 10.1126/science.aat2512
21 Luo YJ , Li YD , Wang L , et al. Nucleus accumbens controls wakefulness by a subpopulation of neurons expressing dopamine D(1) receptors[J]. Nat Commun, 2018, 9 (1): 1576.
doi: 10.1038/s41467-018-03889-3
22 Yang SR , Hu ZZ , Luo YJ , et al. The rostromedial tegmental nucleus is essential for non-rapid eye movement sleep[J]. PLoS Biol, 2018, 16 (4): e2002909.
doi: 10.1371/journal.pbio.2002909
23 Li YD , Luo YJ , Xu W , et al. Ventral pallidal GABAergic neurons control wakefulness associated with motivation through the ventral tegmental pathway[J]. Mol Psychiatry, 2021, 26 (7): 2912- 2928.
doi: 10.1038/s41380-020-00906-0
24 Chen CR , Zhong YH , Jiang S , et al. Dysfunctions of the paraventricular hypothalamic nucleus induce hypersomnia in mice[J]. Elife, 2021, 10, e69909.
doi: 10.7554/eLife.69909
25 Guo F , Holla M , Diaz MM , et al. A circadian output circuit controls sleep-wake arousal in drosophila[J]. Neuron, 2018, 100 (3): 624- 635.e4.
doi: 10.1016/j.neuron.2018.09.002
26 Jing M , Zhang P , Wang G , et al. A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies[J]. Nat Biotechnol, 2018, 36 (8): 726- 737.
doi: 10.1038/nbt.4184
27 Sun F , Zeng J , Jing M , et al. A genetically encoded fluorescent sensor enables rapid and specific detection of dopamine in flies, fish, and mice[J]. Cell, 2018, 174 (2): 481- 496.e19.
doi: 10.1016/j.cell.2018.06.042
28 Feng J , Zhang C , Lischinsky JE , et al. A genetically encoded fluorescent sensor for rapid and specific in vivo detection of norepinephrine[J]. Neuron, 2019, 102 (4): 745- 761.e8.
doi: 10.1016/j.neuron.2019.02.037
29 Ai S , Yin Y , Chen Y , et al. Promoting subjective preferences in simple economic choices during nap[J]. Elife, 2018, 7, e40583.
doi: 10.7554/eLife.40583
30 Liu Y , Lin W , Liu C , et al. Memory consolidation reconfigures neural pathways involved in the suppression of emotional memories[J]. Nat Commun, 2016, 7, 13375.
doi: 10.1038/ncomms13375
31 He J , Sun HQ , Li SX , et al. Effect of conditioned stimulus exposure during slow wave sleep on fear memory extinction in humans[J]. Sleep, 2015, 38 (3): 423- 431.
doi: 10.5665/sleep.4502
32 Zhang Y , Ren R , Lei F , et al. Worldwide and regional prevalence rates of co-occurrence of insomnia and insomnia symptoms with obstructive sleep apnea: A systematic review and meta-analysis[J]. Sleep Med Rev, 2019, 45, 1- 17.
doi: 10.1016/j.smrv.2019.01.004
33 Zhang Y , Ren R , Yang L , et al. Polysomnographic nighttime features of narcolepsy: A systematic review and meta-analysis[J]. Sleep Med Rev, 2021, 58, 101488.
doi: 10.1016/j.smrv.2021.101488
34 Chen SJ , Shi L , Bao YP , et al. Prevalence of restless legs syndrome during pregnancy: A systematic review and meta-analysis[J]. Sleep Med Rev, 2018, 40, 43- 54.
doi: 10.1016/j.smrv.2017.10.003
35 Shi L , Chen SJ , Ma MY , et al. Sleep disturbances increase the risk of dementia: A systematic review and meta-analysis[J]. Sleep Med Rev, 2018, 40, 4- 16.
doi: 10.1016/j.smrv.2017.06.010
36 Zhang Y , Ren R , Yang L , et al. Sleep in Alzheimer's disease: A systematic review and meta-analysis of polysomnographic findings[J]. Transl Psychiatry, 2022, 12 (1): 136.
doi: 10.1038/s41398-022-01897-y
37 Wang Z , Chen WH , Li SX , et al. Gut microbiota modulates the inflammatory response and cognitive impairment induced by sleep deprivation[J]. Mol Psychiatry, 2021, 26 (11): 6277- 6292.
doi: 10.1038/s41380-021-01113-1
38 Zhang Y , Ren R , Sanford LD , et al. Sleep in posttraumatic stress disorder: A systematic review and meta-analysis of polysomnographic findings[J]. Sleep Med Rev, 2019, 48, 101210.
doi: 10.1016/j.smrv.2019.08.004
39 Zhang Y , Ren R , Sanford LD , et al. Sleep in Parkinson's disease: A systematic review and meta-analysis of polysomnogra-phic findings[J]. Sleep Med Rev, 2020, 51, 101281.
doi: 10.1016/j.smrv.2020.101281
40 Ai S , Zhang J , Zhao G , et al. Causal associations of short and long sleep durations with 12 cardiovascular diseases: Linear and nonlinear Mendelian randomization analyses in UK Biobank[J]. Eur Heart J, 2021, 42 (34): 3349- 3357.
doi: 10.1093/eurheartj/ehab170
41 Li Y , Vgontzas AN , Fernandez-Mendoza J , et al. Insomnia with physiological hyperarousal is associated with hypertension[J]. Hypertension, 2015, 65 (3): 644- 650.
doi: 10.1161/HYPERTENSIONAHA.114.04604
42 Ren R , Li Y , Zhang J , et al. Obstructive sleep apnea with objective daytime sleepiness is associated with hypertension[J]. Hypertension, 2016, 68 (5): 1264- 1270.
doi: 10.1161/HYPERTENSIONAHA.115.06941
43 Ren R , Covassin N , Zhang Y , et al. Interaction between slow wave sleep and obstructive sleep apnea in prevalent hypertension[J]. Hypertension, 2020, 75 (2): 516- 523.
doi: 10.1161/HYPERTENSIONAHA.119.13720
44 Zhang X , Wang S , Xu H , et al. Metabolomics and microbiome profiling as biomarkers in obstructive sleep apnoea: A comprehensive review[J]. Eur Respir Rev, 2021, 30 (160): 200220.
doi: 10.1183/16000617.0220-2020
45 Guan J , Yi H , Zou J , et al. Distinct severity stages of obstructive sleep apnoea are correlated with unique dyslipidaemia: Large-scale observational study[J]. Thorax, 2016, 71 (4): 347- 355.
doi: 10.1136/thoraxjnl-2015-207403
46 Jhuang YH , Chung CH , Wang ID , et al. Association of obstructive sleep apnea with the risk of male infertility in Taiwan[J]. JAMA Netw Open, 2021, 4 (1): e2031846.
doi: 10.1001/jamanetworkopen.2020.31846
47 Babiloni AH , Bellemare A , Beetz G , et al. The effects of non-invasive brain stimulation on sleep disturbances among different neurological and neuropsychiatric conditions: A systematic review[J]. Sleep Med Rev, 2021, 55, 101381.
doi: 10.1016/j.smrv.2020.101381
48 Wang HX , Wang L , Zhang WR , et al. Effect of transcranial alternating current stimulation for the treatment of chronic insomnia: A randomized, double-blind, parallel-group, placebo-controlled clinical trial[J]. Psychother Psychosom, 2020, 89 (1): 38- 47.
doi: 10.1159/000504609
49 Shamim-Uzzaman QA , Bae CJ , Ehsan Z , et al. The use of telemedicine for the diagnosis and treatment of sleep disorders: An American Academy of Sleep Medicine update[J]. J Clin Sleep Med, 2021, 17 (5): 1103- 1107.
doi: 10.5664/jcsm.9194
50 Roenneberg T . Chronobiology: The human sleep project[J]. Nature, 2013, 498 (7455): 427- 428.
doi: 10.1038/498427a
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