Journal of Peking University(Health Sciences) ›› 2014, Vol. 46 ›› Issue (6): 941-944.

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Effects and clinical significance of virus load on red blood cell parameters in different stage of hepatitis B

GAO Peng1, XIAO Ping1△, YANG Yan-ling1△, CHEN Qing-feng1, MAO Xiao-rong2, ZHAO Zheng-bin2, SHI Lei3, YANG Li-zhong4, ZHOU Wei1   

  1. (1. Institute of Infection, First Hospital of Lanzhou University, 2. Department of Infection, First Hospital of Lanzhou University, 3. Clinical laboratory, Second Hospital of Lanzhou University, Lanzhou 730000, China; 4. Clinical Laboratory, Jingchuan County People’s Hospital, Gansu Jingchuan 744300, China)
  • Online:2014-12-18 Published:2014-12-18

Abstract: Objective:To evaluate the effect of the viral load on the red blood cell parameters in chro-nic hepatitis B patients and its clinical significance. Methods: In the study, 373 chronic hepatitis B patients were recruited, including 123 alanine transaminase (ALT) normal patients (ALT<40 U/L),128 ALT greater than or equal to the upper limit of normal, and less than 2 times higher than the upper limit of normal patients(40 U/L ≤ALT<80 U/L), and 122 ALT greater than or equal to 2 times higher than the upper limit of normal patients (ALT≥80 U/L). The blood routine parameters were measured by automatic blood cell counter. The liver function parameters were measured by automatic biochemical analyzer, the hepatitis B virus loads were measured by quantitative PCR analyzer and the results were analyzed by covariance analysis. Results: In the ALT normal chronic hepatitis B patients group, the viral load had minor effects on the red blood cell parameters.But in the ALT abnormal chronic hepatitis B patients group, the viral load had a significant effect on the red blood cell parameters, and the effect was most manifest in the ALT≥ double upper limit of normal group. The specific performance was that with the viral load increasing,   the red blood cell [low copies group (4.10±0.67)×1012/L,medium copies group (3.92±0.69)×1012/L,high copies group (3.54±0.90)×1012/L], the hemoglobin[low co-pies group (129.66±21.12 ) g/L, medium copies group (126.23±23.38) g/L, high copies group (112.98±27.77) g/L], the hematocrit (low copies group 37.66±5.68, medium copies group 37.03±6.03, high copies group 33.34±8.15) decreased(P=0.006,0.007,0.010),the mean corpuscular volume [low copies group (92.17±6.53) fL, medium copies group (94.85±7.95) fL, high copies group (101.63±11.33) fL], the mean corpuscular hemoglobin [low copies group (31.70±2.22) pg, medium copies group (33.11±3.62) pg, high copies group (34.65±3.13) pg], the mean corpuscular hemoglobin concentration [low copies group (344.28±17.17) g/L, medium copies group (351.33±16.90) g/L, high copies group (358.12±15.67) g/L], and the red blood cell distribution widthstandard deviation [low copies group (52.49±9.04) fL, medium copies group (56.96±7.19) fL, high copies group (61.23±7.23) fL] increased(P=0.000,0.000,0.002,0.000). Conclusion: Observing the effect of the viral load on the red blood cell parameters in chronic hepatitis B patients can reflect the effect of hepatitis B virus on the immune response and liver function in the different pathological stages, providing theoretical support for the clinical antiviral treatment.

Key words: Hepatitis B, chronic, Viral load, Erythrocytes

[1] GAO Peng,LUO Yan-ping,LI Jun-feng,CHEN lin,MAO Xiao-rong. Effects of hepatitis B virus on Th17, Treg and Th17/Treg ratio in different alanine aminetransferase stages [J]. Journal of Peking University (Health Sciences), 2022, 54(2): 272-277.
[2] Hong-yu GAO,Jing-ling XU,Huan-xin MENG,Lu HE,Jian-xia HOU. Effect of initial periodontal therapy on blood parameters related to erythrocyte and platelet in patients with type 2 diabetes mellitus and chronic periodontitis [J]. Journal of Peking University (Health Sciences), 2020, 52(4): 750-754.
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