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Journal of Peking University (Health Sciences) ›› 2021, Vol. 53 ›› Issue (6): 1205-1208. doi: 10.19723/j.issn.1671-167X.2021.06.034

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  • Received:2019-11-26 Online:2021-12-18 Published:2021-12-13
  • Supported by:
    National Key R&D Program of the Ministry of Science and Technology of China(2017YFC1600200);National Natural Science Foundation of China(81703257)

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  • R114

Figure 1

Effect of titanium dioxide nanoparticles on body weight of SD rats after 90 days of oral exposure ($\overline{x}$±s, n=5) A, female rats; B, male rats."

Table 1

Effect of titanium dioxide nanoparticles on white blood cell related indicators of SD rats after 90 days of oral exposure ($\overline{x}$±s, n=5)"

Exposure group WBC/(×109/L) LYM/(×109/L) MOD/(×109/L) GRN/(×109/L) LYM% MOD% GRN%
Female
Control 3.84±1.02 2.86±0.82 0.14±0.05 0.84±0.27 74.28±5.58 3.52±0.58 22.20±5.25
2 mg/kg 3.62±0.61 2.82±0.58 0.10±0.00 0.70±0.32 78.22±6.98 3.86±0.57 17.92±7.01
10 mg/kg 3.28±0.40 2.54±0.38 0.12±0.04 0.62±0.16 77.66±5.20 3.38±0.63 18.96±4.93
50 mg/kg 5.36±1.06* 3.90±1.10* 0.18±0.04 1.28±0.25* 71.32±8.73 3.52±0.99 25.16±7.80
Male
Control 4.74±0.82 3.04±0.59 0.18±0.04 1.52±0.36 63.96±4.79 3.74±0.34 32.30±4.96
2 mg/kg 4.68±0.73 3.02±0.63 0.16±0.05 1.50±0.21 63.72±4.82 3.28±0.80 33.00±4.91
10 mg/kg 3.02±0.44* 1.74±0.27* 0.10±0.00 1.18±0.26 57.90±4.44 3.32±0.66 38.78±4.25
50 mg/kg 5.58±1.97 3.70±2.24 0.28±0.15 1.23±0.36 67.38±12.91 5.03±1.23* 27.60±13.34

Table 2

Effect of titanium dioxide nanoparticles on red blood cell related indicators of SD rats after 90 days of oral exposure ($\overline{x}$±s, n=5)"

Exposure group RBC/(×1012/L) HGB/(g/L) HCT/% MCV/fL MCH/pg MCHC/(g/L) RDW/%
Female
Control 7.52±0.35 140.20±6.22 40.36±1.55 53.72±1.61 18.66±0.82 347.20±8.47 12.96±0.38
2 mg/kg 7.51±0.55 143.40±6.02 41.64±1.90 55.56±2.73 19.14±1.02 344.40±5.22 13.36±0.36
10 mg/kg 7.57±0.40 143.00±3.32 41.66±1.35 55.12±1.52 18.92±0.70 343.20±4.27 13.58±0.39*
50 mg/kg 8.01±0.30 149.40±7.54* 43.38±2.02* 54.16±2.40 18.66±1.01 344.20±7.66 13.62±0.38*
Male
Control 8.32±0.36 142.60±9.66 41.72±2.54 50.18±3.62 17.16±1.54 341.80±7.40 14.78±0.45
2 mg/kg 8.17±0.17 146.40±3.65 43.00±1.45 52.66±1.35 17.94±0.42 340.60±4.98 14.56±0.48
10 mg/kg 8.62±0.25 157.60±7.80# 46.44±2.71# 53.86±1.86* 18.28±0.47 339.40±2.97 14.92±0.25
50 mg/kg 8.39±0.19 148.00±5.48 43.40±1.43 51.72±1.36 17.62±0.48 341.20±2.86 15.26±0.50

Table 3

Effect of titanium dioxide nanoparticles on platelet related indicators of SD rats after 90 days of oral exposure ($\overline{x}$±s, n=5)"

Exposure group PLT/(×109/L) PCT/% MPV/fL PDW/%
Female
Control 338.80±62.42 0.22±0.06 6.66±0.40 12.28±0.88
2 mg/kg 267.20±90.56 0.17±0.06 6.66±0.47 12.26±0.74
10 mg/kg 350.00±18.12 0.23±0.02 6.62±0.22 12.18±0.20
50 mg/kg 337.40±46.90 0.22±0.04 6.64±0.15 12.32±0.25
Male
Control 320.80±60.28 0.20±0.05 6.52±0.19 12.06±0.38
2 mg/kg 315.20±38.94 0.20±0.03 6.38±0.16 11.76±0.31
10 mg/kg 313.60±46.16 0.19±0.04 6.42±0.24 11.68±0.36
50 mg/kg 327.60±72.87 0.20±0.05 6.30±0.23 11.72±0.58
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