Journal of Peking University (Health Sciences) ›› 2023, Vol. 55 ›› Issue (6): 1144-1148. doi: 10.19723/j.issn.1671-167X.2023.06.030

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辉 李1,敏 彭2,娇 武1,青霞 张3,博涵 宁3,颖 董3,*()   

  • Received:2022-09-30 Online:2023-12-18 Published:2023-12-11
  • Contact: 颖 董 E-mail:dongying_999@163.com
  • Supported by:
    the Key Technology Research Plan Project of Inner Mongolia Autonomous Region(2021GG0283)

RICH HTML

  

CLC Number: 

  • R361.2

Figure 1

A representative image for positive p16/Ki67 dual staining, with p16-positive cytoplasm (brown) and Ki67-positive nucleus (red) in the same cell (indicated by the arrows, ×400)"

Figure 2

Hematoxylin and eosin (HE) staining of tissue correspond to p16/Ki67 dual staining positive (×200)"

Figure 3

Image illustrates one exfoliated epithelial cell of the cervix with p16/Ki67 dual staining false negative (×400)"

Figure 4

Hematoxylin and eosin (HE) staining of tissue correspond to p16/Ki67 dual staining false negative(×200)"

Figure 5

Ki67 immunohistochemical staining correspond to p16/Ki67 dual staining false negative (×200)"

Figure 6

p16 immunohistochemical staining correspond to p16/Ki67 dual staining false negative (×200)"

1 Shen HP , Hsiao YH , Yang SF , et al. Single nucleotide polymorphisms and haplotypes of carbonic anhydrase 9 can predict invasive squamous cell carcinoma of uterine cervix[J]. Int J Med Sci, 2018, 15 (6): 587- 594.
doi: 10.7150/ijms.23359
2 梁江红, 罗蕊丽. p16/Ki67细胞学双染检测对宫颈癌筛查患者的分流管理现状[J]. 湖北医药学院学报, 2016, 35 (2): 228- 230.
doi: 10.13819/j.issn.1006-9674.2016.02.029
3 Renshaw AA , Deschenes M , Auger M . ASC/SIL Ratio for cytotechnologists a surrogate marker of screening sensitivity[J]. Am J Clin Pathol, 2009, 131 (6): 776- 781.
doi: 10.1309/AJCPXANG59GPHJNU
4 Origoni M , Carminati G , Sideri M , et al. "Low-grade positivity" of HPV viral load after atypical squamous cells of undetermined significance (ASC-US) cytology identifies women at low-risk for cervical intraepithelial neoplasia grade 2 and 3[J]. Eur J Gynaecol Oncol, 2011, 33 (3): 261- 264.
5 Schmidt D , Bergeron C , Denton KJ , et al. p16 /ki-67 dual-stain cytology in the triage of ASCUS and LSIL Papanicolaou cytology: Results from the European equivocal or mildly abnormal Papanicolaou cytology study[J]. Cancer Cytopathol, 2011, 119 (3): 158- 166.
doi: 10.1002/cncy.20140
6 潘秦镜. TBS子宫颈细胞学报告系统回顾及新版解读[J]. 中国妇产科临床杂志, 2017, 18 (1): 95- 96.
7 Yu LL , Chen W , Lei XQ , et al. Evaluation of p16/Ki-67 dual staining in detection of cervical precancer and cancers: A multicenter study in China[J]. Oncotarget, 2016, 7 (16): 21181- 21189.
doi: 10.18632/oncotarget.8307
8 卢珊珊, 沈丹华. 第5版WHO女性生殖器官肿瘤分类的更新及解读[J]. 中华妇产科杂志, 2021, 56 (8): 588- 592.
doi: 10.3760/cma.j.cn112141-20210518-00273
9 Pi X , Wang L , Chen S . Application of p16/Ki-67 dual-staining cytology in cervical cancers[J]. J Cancer, 2019, 10 (12): 2654- 2660.
doi: 10.7150/jca.32743
10 Cheng JX , Yao LL , Xiang H , et al. Cervical cytology ASCUS patients with HPV detection and clinical value[J]. Clin Exp Obstet Gynecol, 2016, 43 (4): 592- 596.
doi: 10.12891/ceog3100.2016
11 Prigenzi KCK , Heinke T , Salim RC , et al. Dual p16 and Ki-67 expression in liquid-based cervical cytological samples compared to pap cytology findings, biopsies, and HPV testing in cervical can-cer screening: A diagnostic accuracy study[J]. Acta Cytol, 2018, 62 (2): 104- 114.
doi: 10.1159/000487504
12 张颖. 122例意义不明确宫颈不典型鳞状上皮细胞(ASCUS)的临床分析[J]. 中国医药指南, 2016, 14 (3): 65- 66.
13 Li Y , Liu J , Gong L , et al. Combining HPV DNA load with p16/Ki-67staining to detect cervical precancerous lesions and predict the progression of CIN1-2 lesions[J]. Virol J, 2019, 16 (1): 117.
doi: 10.1186/s12985-019-1225-6
14 Clarke MA , Cheung LC , Castle PE , et al. Five-year risk of cervical precancer following p16/Ki-67 dual-stain triage of HPV-positive women[J]. JAMA Oncol, 2019, 5 (2): 181- 186.
doi: 10.1001/jamaoncol.2018.4270
15 Areán-Cuns C , Mercado-Gutiérrez M , Paniello-Alastruey I , et al. Dual staining for p16/Ki67 is a more specific test than cytology for triage of HPV-positive women[J]. Virchows Arch, 2018, 473 (5): 599- 606.
16 Benevolo M , Mancuso P , Allia E , et al. Interlaboratory concor-dance of p16/Ki-67 dual-staining interpretation in HPV-positive women in a screening population[J]. Cancer Cytopathol, 2020, 128 (5): 323- 332.
doi: 10.1002/cncy.22248
17 徐海沧, 胡沙沙, 耿守孟, 等. p16/Ki-67双染在宫颈癌筛查分流中的应用价值[J]. 诊断病理学杂志, 2022, 29 (7): 614- 619.
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