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A multi-center cross-sectional survey of medicine application in patients with osteoarthritis in China
Received date: 2018-08-04
Online published: 2018-12-18
Objective: To investigate the clinical characteristics, the medicine application and to eva-luate the disease activity in patients with osteoarthritis (OA) in China.Methods:This was a cross-sectional study. Totally 1 066 cases of OA from 40 hospitals in China from April to October 2017 were retrospectively enrolled. Demographic characteristics, clinical data, medicine application, and joint function were evaluated. All the data were analyzed by SPSS software 19.0. t test, Mann-Whitney U test and chi-square test were used for statistical analysis.Results:In the 1 066 cases, the male-to-female ratio was 1 :3.6 and the average age was (61.9±11.0) years, with an age range from 36 to 94 years. The incidence of knee OA, hip OA, and hand OA were respectively 81.9% (873/1 066), 14.1% (150/1 066), and 36.3% (387/1 066). In the study, 242 (22.7%) cases had two kinds of joint areas involved and three joint areas were involved in 51 cases (4.8%), and 56.6% (603/1 066) of the patients used more than one kind of non- steroid anti-inflammatory drugs (NSAIDs) while 61.2% (652/1 066) used disease modifying osteoarthritis drugs (DMOADs), including glucosamine (37.5%, 400/1 066), chondroitin sulfate (2.0%, 21/1 066), diacetate (5.9%, 63/1 066), and the combination of these drugs (15.8%, 168/1 066). 8.6% (92/1 066) patients only took analgesics to relieve the pain, not using any kind of NSAIDs or DMOADs. And 232 patients (21.7%) had intra-articular injections, including 9.2% (98/1 066) sodium hyaluronate, 4.5%(48/1 066) glucocorticoid, and 8.1% (86/1 066) combination of the two drugs. The proportion of the patients taking topical drugs accounted for 26.5% (283/1 066) and physical therapy accounted for 15.8% (168/1 066). Compared with those who suffered from knee OA, the patients who suffered from hip OA had more severe disease assessment. Moreover, there were significant differences in pain (Z=-7.625, P<0.001), morning stiffness (Z=-6.229, P<0.001), and joint function (Z=-6.777, P<0.001) between the two groups of the patients who suffered from knee or hip OA with The Western Ontario and McMaster Universities (WOMAC) osteoarthritis index. Furthermore, patients with hip OA took more analgesics (χ 2=24.838, P<0.001). Conclusion:Oral NSAIDs and DMOADs are wildly used in patients with OA in China. However, the treatment of some patients still need to be improved. Patients with hip OA are more seriously ill and require aggressive treatment.
Key words： Osteoarthritis; Drug therapy; Cross-sectional study
Xiao-ying ZHANG , Jia-jing PENG , Chuan-hui LIU , Xiao-yan CAI , Jiang-lin ZHANG , Yi-fang MEI , Hong-tao JIN , Xiao-fei WANG , Hong MO , Zhan-guo LI . A multi-center cross-sectional survey of medicine application in patients with osteoarthritis in China[J]. Journal of Peking University(Health Sciences), 2018 , 50(6) : 1044 -1048 . DOI: 10.19723/j.issn.1671-167X.2018.06.018
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