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Journal of Peking University (Health Sciences) ›› 2026, Vol. 58 ›› Issue (1): 1-9. doi: 10.19723/j.issn.1671-167X.2026.01.001

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Research progress in diagnosis and treatment of non-tumorous salivary gland diseases

Xin CONG1,2, Jiazeng SU1,3, Liling WU2, Chong DING1,4, Wei LI1,3, Guangyan YU1,3,*()   

  1. 1. Salivary Gland Disease Research Center, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China
    2. Department of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Beijing 100191, China
    3. Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China
    4. Central Laboratory, Peking University School and Hospital of Stomatology, Beijing 100081, China
  • Received:2025-10-21 Online:2026-02-18 Published:2025-12-10
  • Contact: Guangyan YU
  • Supported by:
    the National Natural Science Foundation of China(82270993); the National Natural Science Foundation of China(31972908); the National Natural Science Foundation of China(82170977)

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Abstract:

Salivary gland diseases are common disorders in the oral and maxillofacial region, mainly classified into two categories: Tumorous and non-tumorous. Non-tumorous salivary gland diseases include various types such as salivary gland inflammation, Sjögren syndrome, granulomatous diseases, and developmental abnormalities. Some of these diseases are local lesions, while others are closely associated with systemic diseases, often accompanied by impaired salivary secretion function, leading to xerostomia and secondary lesions. Over the past more than 20 years, the Salivary Gland Disease Research Center of Peking University School and Hospital of Stomatology has conducted systematic and in-depth studies focusing on the regulation of salivary secretion function by tight junction proteins, the clinicopathological characteristics, prevention and treatment of novel chronic sialadenitis [including immunoglobulin (Ig) G4-related sialadenitis, 131I-induced sialadenitis, and eosinophilic sialodochitis], stem cells from human exfoliated deciduous teeth-based therapy for Sjögren syndrome, and salivary gland developmental abnormalities. These studies provide important references for the basic research, clinical diagnosis and treatment of related diseases.

Key words: Salivary glands, Tight junction proteins, Immunoglobulin G4-related sialadenitis, 131I-induced sialadenitis, Eosinophilic sialodochitis

CLC Number: 

  • R781.7
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