细胞色素P450 3A4基因多态性分子检测指导分娩镇痛舒芬太尼用药

doi:10.3969/j.issn.1671-167X.2015.04.021

Journal of Peking University(Health Sciences) ›› 2015, Vol. 47 ›› Issue (4): 653-656. doi: 10.3969/j.issn.1671-167X.2015.04.021

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Detection of cytochrome P450 3A4 gene polymorphism guides for labor analgesia with sufentanil medication

CHI Li-qun1，LU Xin1，WANG Lei1，LIU Shu-ping2，DING Nan2，ZHANG Hong-ying2，E Wen2△

（1.Department of Pharmacy, Haidian Maternal & Health Hospital, Beijing 100080, China; 2.Department of Pathology, Peking University School of Basic Medical Sciences, Beijing 100191, China）

Online:2015-08-18 Published:2015-08-18
Contact: E Wen E-mail:ew@bjmu.edu.cn
Supported by:
Supported by the Incubating Projects of Health Improving of the Capital Residents from Beijing Municipal Science & Technology Commission

Abstract

Abstract:

Objective：To investigate the relationship between single nucleotide polymorphisms (SNPs) of cytochrome P450 (CYP450) 3A4 rs2242480 and interindividual differences of sufentanil consumption in accouchement sans douleur. Methods: A total of 131 parturient women were collected. According to the distribution of genotypes and allele frequencies of rs2242480, the doses of sufentanil were individually designed. CC homozygotes were given the standard analgesia dose, CT heterozygotes and TT homozygotes were given 87.6% of standard sufentanil dose. Results:Visual analogue score (VAS) between CC group and CT/TT group were 3.67±1.2 and 3.44±1.5, consistent with the expected analgesic standards. The difference was not statistically significant. Conclusion:The parturient women carrying CT heterozygotes and TT homozygotes of CYP3A4 rs2242480 required less sufentanil in accouchement sans douleur.

Key words: Cytochrome P450 CYP3A, Polymorphism, single nucleotide, Parturition, Analgesia, Sufentanil

CLC Number:

R451

CHI Li-Qun, LU Xin, WANG Lei, LIU Shu-Ping, DING Nan, ZHANG Hong-Ying, E Wen. Detection of cytochrome P450 3A4 gene polymorphism guides for labor analgesia with sufentanil medication[J].Journal of Peking University(Health Sciences), 2015, 47(4): 653-656.

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