Abstract: Objective：To observe the multiple influence of cholesterol-lowering drug (simvastatin) on ankle brachial index (ABI), flow-mediated dilation (FMD) and nitroglycerin-mediated dilation (NMD) of brachial artery blood vessel endothelium, and plasma level of monocyte chemotactic protein 1 (MCP-1) of hypercholesterolemia patients without coronary heart disease (CHD). Methods：In the study, 51 patients with hypercholesterolemia application were treated with simvastatin (20 mg/d) therapy for 12 weeks. The metabolic index, ankle brachial index (ABI), FMD of brachial artery blood vessel endothelium detected by color doppler ultrasound instrument, the NMD of artery endothelial and the level of MCP 1 were measured before and after therapy respectively. All the results were analyzed and compared with another 30 cases of hypercholesterolemia patients selected without simvastatin treatment. Results：After simvastatin therapy, the TC (total cholesterol) and LDL-C (low density lipoprotein cholesterin) levels were reduced apparently，the values decreased from the original (6.06±1.03) mmol/L and (3.60± 0.82) mmol/L to (4.98±1.34) mmol/L and (3.41±0.10) mmol/L respectively (P<0.01, P< 0.05). Compared with no simvastatin treatment, the bilateral ABI levels were significantly elevated. The right side of ABI (ABIR) elevated from 1.11±0.06 to 1.19±0.07, and the left side of ABI (ABIL) also elevated from 1.12±0.06 to 1.19±0.10 (both sides were P<0.01). The FMD significantly increased from 7.75%±11.30% to 14.20%±15.39% (P < 0.05). The plasma levels of MCP-1 were apparently reduced from (112.0±7.8) ng/L to (108.9±6.2) ng/L (P < 0.05). All these items showed no obvious change within the control group. Conclusion：The API, FMD and plasma levels of MCP-1 of hypercholesterolemia patients without clear coronary heart disease can be improved by simvastatin treatment.

Key words: Hypercholesterolemia, Simvastatin, Ankle brachial index, Endothelium vascular, Monocyte chemoattractant proteins