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Journal of Peking University(Health Sciences) ›› 2014, Vol. 46 ›› Issue (6): 875-878.

• Articles • Previous Articles     Next Articles

Relationship between serum histamine levels and ST-segment resolution in patients with acute myocardial infarction treated with primary percutaneous coronary intervention

CHEN Shao-min, MU Di, CUI Ming△, REN Chuan, ZHANG Shu, GUO Lijun   

  1. (Department of Cardiology, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing 100191, China)
  • Online:2014-12-18 Published:2014-12-18

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Abstract: Objective：To investigate the dynamic changes in serum histamine levels and their association with ST-segment resolution in patients with acute ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). Methods: A total of 84 consecutive STEMI patients who received primary PCI were enrolled in this study. The dynamic changes in serum histamine levels were observed from before PCI to 1 week after PCI. Factors associated with ST-segment resolution were identified by multivariate regression analysis. Results: The serum histamine levels of STEMI patients decreased during the first week after PCI. Multivariate regression analysis showed that the factors associated with ST-segment resolution 2 h after PCI were: the histamine level 2 h after PCI (r=-0.361, P=0.001), pain to balloon time, infarct related artery, and thrombolysis in myocardial infarction (TIMI) flow grade after PCI. Conclusion: The higher histamine level 2 h after PCI was independently associated with poor myocardial reperfusion in STEMI patients.

Key words: Myocardial infarction, Histamine, Myocardial reperfusion, Percutaneous coronary intervention, Electrocardiography

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