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Journal of Peking University(Health Sciences) ›› 2014, Vol. 46 ›› Issue (1): 120-124.

• Articles • Previous Articles     Next Articles

Expression and significance of tumor necrosis factor receptor associated protein 1 in epithelial ovarian cancer

MA Rui-qiong, CHENG Hong-yan, YE Xue, CHEN Jun, CUI Heng, WEI Li-hui, CHANG Xiao-hong△   

  1. (Gynecologic Oncology Center, Peking University People’s Hospital, Beijing 100044, China)
  • Online:2014-02-18 Published:2014-02-18

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Abstract: Objective：To explore the levels of TRAP1 and its roles in patients with ovarian tumor, and investigate the correlation between the expressions of TRAP1 in ovarian tumor tissues and related clinicopathological characteristics. Methods: 38 health women, 50 cases of benign ovarian tumors and 114 cases of epithelial ovarian cancers were examined by Real -time RT-PCR and immunohistochemical staining. Results: The immunohistochemical analysis demonstrated that TRAP1 protein was mainly located in the cytoplasm, the protein and mRNA expression of TRAP1 in ovarian cancer were significantly increased compared with those of normal control and benign tumor (P<0.05). The protein and mRNA expression of TRAP1 was related to histological grade and pathologic types (P<0.05), but not age, clinical stages, lymphnode metastasis or omental metastasis, and the amount of ascites (P>0.05). Conclusion: The high expression of TRAP1 may play potential role in epithelial ovarian cancer occurrence and progress.

Key words: Ovarian neoplasms, TRAP1 protein, human, Immunohistochemistry, Reverse transcriptase polymerase chain reaction

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