17例误诊为IgG4相关疾病患者的临床特点及误诊原因分析

doi:10.19723/j.issn.1671-167X.2019.06.008

Abstract

Abstract:

Objective: To summarize the clinical characteristics of patients misdiagnosed with IgG4-related disease, to analyze the reasons of misdiagnosis and to improve the clinical recognition of the disease.Methods: The general data, clinical manifestations, laboratory examination results and pathological features of 17 patients with IgG4-related diseases misdiagnosed outside the hospital were retrospectively analyzed.Results: Among the 17 patients, there were 9 males and 8 females with a median age of 45 years, and the median time from onset to diagnosis was 12 months. Most patients’ initial admission department was not rheumatology or immunology department. Six of the 17 patients were eventually diagnosed with lymphoproliferative disease, 4 with autoimmune disease, and 2 with infectious disease, Rosai Doffman disease, desmofibromatosis, highly differentiated mucoepidermoid carcinoma of the bottom of the mouth, hypereosinophilic syndrome, asthma and allergic rhinitis in 1 case each. The typical sites of IgG4-related disease were involved in 14 patients, including 6 cases of parotid gland, 2 cases of submandibular gland, 3 cases of pancreas and 2 cases of retroperitoneal lesions. Serum IgG4 was elevated in 10 patients, serum IgG4/IgG value was higher than 10% in 7 patients, serum IgE was increased in 7 patients, complement was decreased in 4 patients, and eosinophilic granulocytes were increased in 3 patients. Pathological biopsy was performed in 15 patients, and infiltration of lymphocyte was observed in 10 patients, IgG4 ⁺ plasma cells were present in 5 patients, the ratio of IgG4 ⁺ plasma cells to IgG ⁺ plasma cells was less than 40% in 4 patients and greater than 40% in 1 patient. However, none of the 15 patients had the storiform pattern of fibrosis and obliterative phlebitis.Conclusion: A variety of diseases can perform as IgG4-related disease witih typical sites involved, elevated serum IgG4, even can be cha-racterized by pathological IgG4 ⁺ plasma cells infiltration. Physicians should pay attention to the differential diagnosis and comprehensively evaluate the patient’s clinical manifestations, and laboratory results. Timely and even repeated pathological biopsy is also needed for definite diagnosis.

Key words: IgG4-related disease, Lymphoproliferative disease, Diagnostic errors

CLC Number:

R593.2

Zi-qiao WANG,Yan-ying LIU,Xia ZHANG,Tian LIU,Li-min REN,Dan-hua SHEN,Yi WANG,Zhan-guo LI. Analysis of the clinical features and misdiagnosis reasons of 17 patients misdiagnosed with IgG4-related disease[J].Journal of Peking University(Health Sciences), 2019, 51(6): 1025-1031.

Figures/Tables 4

Table 1

Table 2

Table 3

Pathological features of patients misdiagnosed as IgG4-RD"

Case	Biopsy site	N/S	SF	OP	IgG4⁺plasma cells/HP	IgG4⁺/IgG⁺ plasma cell	Pathological features	Pathological diagnosis
1	Retroperitoneum	S	-	-	30	50%	Large allotypic lymphocytes infiltrate diffusely, CD19(+), CD20(+), CD79a(+)	Non-Hodgkin’s lymphoma, B-cell derived (diffuse large B-cell lymphoma)
2	Lymph node	S	-	-	-	-	Follicular growth of central cells and centroblasts, CD19(+), CD20(+), CD10(+), Bcl-2(+), Bcl-6(+)	Non-Hodgkin’s lymphoma, B-cell derived lymphoma (follicular lymphoma)
3	Submandibular gland	S	-	-	-	-	The central cell-like cells invade the glandular epithelium, CD20(+), CD79a(+), CD5(-), CD10(-), CD23(-), cyclinD1(-)	Non-Hodgkin’s lymphoma, B-cell derived lymphoma (mucosa-asso-ciated lymphoid tissue lymphoma)
4	Parotid gland	N	-	-	-	-	Allotypic lymphocytes infiltrate the marginal area around the lymphoid follicle, CD20(+), CD79a(+), CD10(-), CD23(-)	Non-Hodgkin’s lymphoma, B-cell derived (peripheral B-cell lymphoma)
5	Parotid gland	N	-	-	-	-	The central cell-like cells invade the glandular epithelium, CD20(+), CD79a(+), CD5(-), CD10(-), CD23(-), cyclinD1(-)	Non-Hodgkin’s lymphoma, B-cell derived lymphoma (mucosa-asso-ciated lymphoid tissue lymphoma)
6	Retroperitoneal lymph node	N	-	-	100	<40%	Lymphoid hyperplasia with numerous plasma cell lamellar infiltration, CD20(+), CD79a(+), CD3(+), CD38(+), CD138(+)	Castleman disease
7	ND	ND	ND	ND	ND	ND	ND	ND
8	Parotid gland	S	-	-	-	-	Lymphocyte infiltration	Chronic mumps
9	Lacrimal gland	S	-	-	>50	>30%	Glands atrophy, fibrous hyperplasia, lymphocyte plasma cell infiltration and lymphoid follicular formation	Lymphoepithelial lacrimal adenitis
10	Pancreas	S	-	-	-	-	Lymphocyte plasma cell infiltration	Pancreatitis
11	Bile duct	S	-	-	-	-	Multiple granulomatous lesions	Parasidiosporidium biliary tract infection
12	Lung	S	-	-	30	<40%	Dilated bronchial tube cavity, damaged tube wall, fibrinous necrosis and fibrous hyperplasia accompanied by patchy lymphocyte plasma cells and neutrophils infiltration, and abscess formation	Bronchiectasis with infection
13	Parotid gland	S	-	-	>50	<40%	Macrophage penetration	Rosai Doffman disease
14	Neck	N	-	-	-	-	Proliferate fibroblasts	Desmofibromatosis
15	Sublingual gland	N	-	-	-	-	Numerous clusters of typical mucinous cells and some epidermoid cells	Highly differentiated mucoepidermoid carcinoma
16	Myocardium	N	-	-	-	-	Infiltration of eosinophilic cells in car-diac tissue	Hypereosinophilic syndrome
17	ND	ND	ND	ND	ND	ND	ND	ND

Table 3

Figure 1

References 13

[1]	Yamamoto M, Takahashi H, Shinomura Y . Mechanisms and assessment of IgG4-related disease: Lessons for the rheumatologist[J]. Nat Rev Rheumatol, 2013,10(3):148-159.
[2]	Umehara H, Okazaki K, Masaki Y , et al. Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011[J]. Nihon Naika Gakkai Zasshi, 2012,22(1):21-30.
[3]	Brito-Zerón P, Ramos-Casals M, Bosch X , et al. The clinical spectrum of IgG4-related disease[J]. Autoimmun Rev, 2014,13(12):1203-1210.
[4]	Carruthers MN, Khosroshahi A, Augustin T , et al. The diagnostic utility of serum IgG4 concentrations in IgG4-related disease[J]. Ann Rheum Dis, 2015,74(1):14-18.
[5]	El-Monayeri M, Nadim A, Abdel-Fattah I , et al. Pathologies associated with serum IgG4 elevation[J]. Int J Rheumatol, 2012,2012(8):1-6.
[6]	Vikram D, Yoh Z, John KC , et al. Consensus statement on the pathology of IgG4-related disease[J]. Mod Pathol, 2012,25(9):1181-1192.
[7]	Hart S, Horsman JM, Radstone CR , et al. Localised extranodal lymphoma of the head and neck: The Sheffield Lymphoma Group Experience (1971—2000)[J]. Clin Oncol, 2004,16(3):186-192.
[8]	陈利红, 施若非, 郑捷 , 等. 托珠单抗成功治疗误诊为IgG4相关性疾病的多中心Castleman病2例国内首报[J]. 中国皮肤性病学杂志, 2017,31(12):1285-1289.
[9]	Vivino FB . Sjogren’s syndrome: clinical aspects[J]. Clin Immunol, 2017,9(182):48-54.
[10]	吴靖林, 陈秉良, 贾强 . ANCA相关性小血管炎25例诊断及误诊分析[J]. 中国误诊学杂志, 2009,9(6):1367-1368.
[11]	Chari ST, Kloeppel G, Zhang L , et al. Histopathologicand clinical subtypes of autoimmune pancreatitis: The Honolulu Consensus Document[J]. Pancreas, 2010,39(5):549-554.
[12]	Cai Y, Shi Z, Bai Y . Review of Rosai-Dorfman disease: new insights into the pathogenesis of this rare disorder[J]. Acta Haematol, 2017,138(1):14-23.
[13]	Taylor TV, Sosa J . Bilateral breast fibromatosis: case report and review of the literature[J]. J Surg Educ, 2011,68(4):320-325.

Metrics

Viewed

Full text

513

HTML			PDF

Just accepted	Online first	Issue	Just accepted	Online first	Issue
0	0	28	0	0	485

From	Others	local

Times	111	402
Rate	22%	78%

Abstract

1425

Just accepted	Online first	Issue

0	0	1425

From	Others	local

Times	1403	22
Rate	98%	2%

Cited

Web of Science	Crossref	ScienceDirect	Search for Citations in Google Scholar >>


This page requires you have already subscribed to WoS.

Shared

Discussed

Comments

Recommended 0

No Suggested Reading articles found!

Case no.	Gender	Age/ years	Time from onset to diagnosis/ month	Initial admission department	Mainly affected organs	Final diagnosis
1	Male	66	10	Urology	Retroperitoneal	Non-Hodgkin’s lymphoma
2	Male	64	4	Gastroenterology	Pancrea, lymph node	Non-Hodgkin’s lymphoma
3	Male	59	96	Rheumatology & Immunology	Submandibular gland, parotid gland	Non-Hodgkin’s lymphoma
4	Male	75	48	Rheumatology & Immunology	Parotid gland, submandibular gland, periorbital	Non-Hodgkin’s lymphoma
5	Female	61	72	Stomatology	Parotid gland	Non-Hodgkin’s lymphoma
6	Male	16	29	Hematology	Retroperitoneal	Castleman disease
7	Female	31	6	Rheumatology & Immunology	Parotid gland	Sj?gren’s syndrome
8	Female	45	60	Stomatology	Parotid gland	Sj?gren’s syndrome
9	Male	10	5	Ophthalmology	Lacrimal gland, extraocular muscle, auricle	ANCA associated vasculitis
10	Female	37	15	General surgery	Pancreas, gastrointestinal tract	Type 2 autoimmune pancreatitis
11	Male	31	9	Gastroenterology	Pancreas, bile duct	Biliary tract fungal infection
12	Male	44	1	Thoracic surgery	Lung	Bronchiectasis with infection
13	Male	28	48	Head and neck surgery	Parotid gland, chest wall	Rosai Doffman disease
14	Female	56	24	Head and neck surgery	Neck	Desmofibromatosis
15	Female	66	3	Stomatology	Sublingual gland	Highly differentiated mucoepidermoid carcinoma of the bottom of the mouth
16	Female	27	7	Gastroenterology	Myocardium, gastrointestinal tract	Hypereosinophilic syndrome
17	Female	45	12	Pneumology	Trachea, nasal	Asthma and allergic rhinitis

Case	EO%↑	IgG4/ (g/L)	IgG/ (g/L)	IgG4/ IgG	IgE/ (IU/mL)	C3↓	C4↓	Kappa light chain↑	Lambda light chain↑	Autoantibodies
1	No	1.053	11.7	9.0%	109.2	No	No	No	No	-
2	No	3.070	10.2	30.1%	251.7	Yes	No	No	No	-
3	No	0.006	9.2	0.1%	16.0	Yes	Yes	No	No	-
4	No	0.213	101.0	0.2%	25.4	Yes	Yes	Yes	No	-
5	No	0.545	12.6	4.3%	3.4	No	Yes	No	No	ANA(+)
6	No	4.540	34.2	13.3%	129.5	No	No	Yes	Yes	ANA(+), RF(+)
7	No	2.230	20.0	11.2%	ND	No	No	ND	ND	anti-SSA(+), anti-Ro-52(+), RF(+)
8	No	1.822	21.4	8.5%	ND	No	No	ND	ND	ANA(+), anti-SSA(+), anti-SSB(+), anti-Ro-52(+)
9	No	1.476	ND	ND	ND	No	No	ND	ND	MPO-ANCA(+)
10	No	0.058	14.6	0.3%	290.4	No	No	ND	ND	-
11	Yes	12.600	17.3	72.8%	2 153.0	No	No	ND	ND	-
12	No	0.501	12.5	4.0%	32.6	No	No	ND	ND	-
13	No	2.660	13.6	19.6%	22.5	No	No	ND	ND	-
14	No	2.360	18.8	12.6%	ND	No	No	ND	ND	ANA(+)
15	No	0.731	15.3	4.8%	54.5	No	No	ND	ND	ANA(+)
16	Yes	3.380	ND	ND	340.0	No	No	ND	ND	ANA(+)
17	Yes	3.520	15.1	23.3%	137.6	No	No	ND	ND	AECA(+)

Analysis of the clinical features and misdiagnosis reasons of 17 patients misdiagnosed with IgG4-related disease

RICH HTML

PDF (PC)

Abstract

Cite this article

share this article

Figures/Tables 4

References 13

Related Articles 4

Metrics

Comments

Recommended 0

[1]	Min FENG,Zhe CHEN,Yong-jing CHENG. A case of duodenal ulcer as prominent manifestation of IgG4-related disease [J]. Journal of Peking University (Health Sciences), 2023, 55(6): 1125-1129.
[2]	Lu FENG,Jia-yu ZHAI,Jin-xia ZHAO. Medical visit status and clinical features in patients with IgG4 related disease [J]. Journal of Peking University (Health Sciences), 2023, 55(6): 1028-1032.
[3]	Guang-ya YU,Xia HONG,Wei LI,Yan-yan ZHANG,Yan GAO,Yan CHEN,Zu-yan ZHANG,Xiao-yan XIE,Zhan-guo LI,Yan-ying LIU,Jia-zeng SU,Wen-xuan ZHU,Zhi-peng SUN. Clinicopathological characteristics and diagnosis of IgG4-related sialadenitis [J]. Journal of Peking University(Health Sciences), 2019, 51(1): 1-3.
[4]	WANG Yun-yun, SUN Wei, HUANG Yi-ning. Cervical spondylosis misdiagnosed as cerebral infarction: a case report [J]. Journal of Peking University(Health Sciences), 2015, 47(5): 883-884.