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Journal of Peking University(Health Sciences) >

2019 , Vol. 51 >Issue 3: 414 - 421

DOI: https://doi.org/10.19723/j.issn.1671-167X.2019.03.007

Hemodynamic changes in standing-up test of children and adolescents with postural tachycardia syndrome

  • Chun-yan TAO ,
  • Hong-xia LI ,
  • Xue-ying LI ,
  • Chao-shu TANG ,
  • Hong-fang JIN ,
  • Jun-bao DU
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  • 1. Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    2. Department of Statistics, Peking University First Hospital, Beijing 100034, China
    3. Department of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Beijing 100191, China
    4. Key Laboratory of Molecular Cardiovascular Science, the Ministry of Education, Beijing 100191, China

Received date: 2019-03-12

  Online published: 2019-06-26

Supported by

Supported by the fundamental Research Funds for the Central Universities: Peking University Clinical Scientist Program (BMU2019LCKXJ001)

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Abstract

Objective: To explore the hemodynamic changes in standing-up test of children and adolescents with postural tachycardia syndrome (POTS) and to compare hemodynamic parameters of POTS patients with decreased cardiac index (CI) and those with not-decreased CI.Methods: A retrospective study was conducted to show the trends of CI, total peripheral vascular resistance index (TPVRI), heart rate and blood pressure in standing-up test of 26 POTS patients and 12 healthy controls, and to compare them between the two groups. The POTS patients were divided into two groups based on CI decreasing or not in standing-up test, namely decreased CI group (14 cases) and not-decreased CI group (12 cases). The trends of the above mentioned hemodynamic parameters in standing-up test were observed and compared between decreased CI group and not-decreased CI group.Results: In standing-up test for all the POTS patients, CI (F=6.936, P=0.001) and systolic blood pressure (F=6.049, P<0.001) both decreased significantly, and heart rate increased obviously (F=113.926, P<0.001). However, TPVRI (F=2.031, P=0.138) and diastolic blood pressure (F=2.018, P=0.113) had no significant changes. For healthy controls, CI (F=3.646, P=0.016), heart rate (F=43.970, P<0.001), systolic blood pressure (F=4.043, P=0.020) and diastolic blood pressure (F=8.627, P<0.001) all increased significantly in standing-up test. TPVRI (F=1.688, P=0.190) did not change obviously. The changing trends of CI (F=6.221, P=0.001), heart rate (F=6.203, P<0.001) and systolic blood pressure (F=7.946, P<0.001) over time were significantly different between the patients and healthy controls, however, no difference was found in TPVRI and diastolic blood pressure (P > 0.05). Among the POTS patients, CI was significantly different between decreased CI group and not-decreased CI group (F=14.723, P<0.001). Systolic blood pressure of the former decreased obviously (F=8.010, P<0.001), but it did not change obviously in the latter (F=0.612, P=0.639). Furthermore, none of the changes of TPVRI, heart rate and diastolic blood pressure in standing-up test were significantly different between the two groups (P > 0.05). Age was an independent factor for decreased CI patients (P=0.013, OR=2.233; 95% CI, 1.183 to 4.216).Conclusion: POTS patients experience vital hemodynamic changes in standing-up test, part of them suffering from decreased CI, but others from not-decreased CI. Age is an independent factor for patients suffering from decreased CI.

Key words： Postural tachycardia syndrome; Cardiac index; Total peripheral vascular resistance index; Children; Adolescents

Cite this article

Chun-yan TAO , Hong-xia LI , Xue-ying LI , Chao-shu TANG , Hong-fang JIN , Jun-bao DU . Hemodynamic changes in standing-up test of children and adolescents with postural tachycardia syndrome[J]. Journal of Peking University(Health Sciences), 2019 , 51(3) : 414 -421 . DOI: 10.19723/j.issn.1671-167X.2019.03.007

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