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Effect of concentrated growth factors combined with guided tissue regeneration in treatment of classⅡ furcation involvements of mandibular molars
Received date: 2018-08-08
Online published: 2020-04-18
Supported by
Supported by the New Technology and New Treatment Foundation of Peking University School;Hospital of Stomatology, the National Natural Science Foundation of China(81600868);the Cao Caifang Periodontal Gengyun Foundation of Peking University School and Hospital of Stomatology(2016)
Objective: Tissues loss due to periodontal disease is typically treated by a variety of rege-nerative treatment modalities, including bone grafts, guided tissue regeneration (GTR) and growth factors, to reform the supporting tissues of teeth. Concentrated growth factors (CGF) are produced by centrifuging blood samples at alternating and controlled speeds using a special centrifuge. The purpose of this study was to evaluate whether GTR could improve the effect of CGF combined with bone graft in the treatment of classⅡ furcations of mandibular molars.Methods: In the present study, thirty-five classⅡ furcation involvements were included and randomly divided into two groups. The experimental group (n=17) accepted GTR combined with CGF and bone graft therapy, and the controlled group (n=18) accepted CGF combined with bone graft therapy. The clinical examinations and cone beam computed tomography (CBCT) were performed at baseline and 1 year post-surgery. Comparisons of clinical and CBCT data before and after operation between the experimental group and the control group were made.Results: The clinical and CBCT data of both groups were not statistically different at baseline (P>0.05). At the end of 1 year post-surgery, the clinical parameters of both groups were significantly improved (P<0.001). The probing depths of the experimental group were (4.81±1.95) mm and (3.56±1.94) mm, respectively, significantly higher than the changes of the control group (P<0.001). The vertical and horizontal attachment gains of the experimental group were (4.11±1.98) mm and (3.84±1.68) mm, respectively, significantly higher than the changes of the control group (P<0.001). At the end of 1 year post-surgery, the experimental group showed significantly higher bone gain at vertical and horizontal directions compared with those of the control group: (3.84±1.68) and (3.88±2.12) mm, respectively (P<0.001).Conclusion: Within the limitation of the present study, GTR showed positive role in the effect of CGF combined with bone graft in the treatment of classⅡ furcation involvements of mandibular molars.
Fei LI , Jing QIAO , Jin-yu DUAN , Yong ZHANG , Xiu-jing WANG . Effect of concentrated growth factors combined with guided tissue regeneration in treatment of classⅡ furcation involvements of mandibular molars[J]. Journal of Peking University(Health Sciences), 2020 , 52(2) : 346 -352 . DOI: 10.19723/j.issn.1671-167X.2020.02.024
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