Objective: To discuss the influencing factors of mental resilience in adolescents with depression, and to analyze the interaction between them by using path analysis, in order to determine the reasonable prevention and treatment measures for clinical practice and provide reference for the study of mental resilience in adolescents with depression. Methods: This survey adopted cross-sectional study and convenience sampling method. General information questionnaire, Connor-Davidson resilience scale (CD-RISC), family assessment device (FAD) and social support rating scale (SSRS) were used to investigate the general information, mental resilience level, family function and social support level of 162 adolescents with depression in Jiaozuo Fourth People ' s Hospital. Multiple linear regression was used to analyze the influencing factors of mental resilience in adolescents with depression. Structural equation model was established by Amos 22.0 software to analyze the influencing factors. Results: (1) The total score of CD-RISC and the scores of toughness, strength and optimism in adolescents with depression were lower than the domestic norm (P < 0.05). (2) The results of multiple linear regression showed that weight, childhood trauma experience, family structure, family function, parental rearing style, parental marital status, social support and depression degree were the influencing factors of psychological resilience of adolescents with depression (P < 0.05). (3) The model showed that weight, childhood trauma experience, family structure, family function and social support had direct effects on the mental resilience of adolescents with depression, and also had indirect effects on the mental resilience of adolescents with depression through the degree of depression (P < 0.05). Conclusion: In this study, we found that weight, childhood trauma experience, social support, depression degree and other factors have an effect on the psychological resilience of adolescents with depression. We suggest that school administrators increase the class time and course content of physical education courses, improve the mental health service system, strengthen mental health services for key groups, and formulate corresponding topics for timely counseling. At the same time, encourage them to actively participate in social practice activities, enhance self-confidence, and thus help to improve the level of psychological resilience of adolescents with depression.