Journal of Peking University(Health Sciences) ›› 2016, Vol. 48 ›› Issue (5): 830-834. doi: 10.3969/j.issn.1671-167X.2016.05.015

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Clinical application of MRI histogram in evaluation of muscle fatty infiltration

ZHENG Yi-ming1, DU Jing2, LI Wen-zhu1, WANG Zhao-xia1, ZHANG Wei1, XIAO Jiang-xi2, YUAN Yun1△   

  1. (1. Department of Neurology, 2. Department of Radiology, Peking University First Hospital, Beijing 100034, China)
  • Online:2016-10-18 Published:2016-10-18
  • Contact: YUAN Yun E-mail:yuanyun2002@sohu.com
  • Supported by:

    Supported by the National Major Scientific and Technological Special Project for the 12th Five-Year Plan (2011ZX09307-001-07) and the International Cooperation Project of the Ministry of Science and Technology of the People’s Republic of China (2010DFA31070)

Abstract:

Objective:To describe a method based on analysis of the histogram of intensity values produced from the magnetic resonance imaging (MRI) for quantifying the degree of fatty infiltration. Methods: The study included 25 patients with dystrophinopathy. All the subjects underwent muscle MRI test at thigh level. The histogram M values of 250 muscles adjusted for subcutaneous fat, representing the degree of fatty infiltration, were compared with the expert visual reading using the modified Mercuri scale. Results: There was a significant positive correlation between the histogram M values and the scores of visual reading (r=0.854, P<0.001). The distinct pattern of muscle involvement detected in the patients with dystrophinopathy in our study of histogram M values was similar to that of visual reading and results in literature. The histogram M values had stronger correlations with the clinical data than the scores of visual reading as follows: the correlations with age (r=0.730, P<0.001) and (r=0.753, P<0.001); with strength of knee extensor (r=-0.468, P=0.024) and (r=-0.460, P=0.027) respectively. Meanwhile, the histogram M values analysis had better repeatability than visual reading with the interclass correlation coefficient was 0.998 (95% CI: 0.997-0.998, P<0.001) and 0.958 (95% CI: 0.946-0.967, P<0.001) respectively. Conclusion: Histogram M values analysis of MRI with the advantages of repeatability and objectivity can be used to evaluate the degree of muscle fatty infiltration.

Key words: Magnetic resonance imaging, Muscle, skeletal, Adipose tissue, Muscle fatty infiltration, Histogram

CLC Number: 

  • R746
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