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Journal of Peking University(Health Sciences) ›› 2019, Vol. 51 ›› Issue (2): 260-264. doi: 10.19723/j.issn.1671-167X.2019.02.011

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Cerebral blood flow measurements in patients with comorbid hypertension and depression using 3D arterial spin labeling

Ying LIU1,Xiang-zhu ZENG1,Zheng WANG1,Han ZHANG2,Xi-lin WANG2,Hui-shu YUAN1,∆()   

  1. 1. Department of Radiology, Peking University Third Hospital, Beijing 100191, China
    2. Department of Consultation Liaison, Peking University Sixth Hospital, Beijing 100191, China
  • Received:2017-04-25 Online:2019-04-18 Published:2019-04-26
  • Contact: Hui-shu YUAN E-mail:huishuy@bjmu.edu.cn
  • Supported by:
    the National Science and Technology Pillar Program during the 11th Five-Year Plan(2009BA77B00)

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Abstract:

Objective: To evaluate cerebral blood flow (CBF) in patients with comorbid hypertension in depression using 3D pseudocontinuous arterial spin labeling (3D pcASL) and to compare the dif-ferences of CBF values in depression, hypertension, and comorbid hypertension between depression and healthy control groups. To investigate the correlation between CBF values and degrees of depression.Methods: Sixteen patients with depression (depression group, 3 males and 13 females, age range of 42-72 years old), sixteen patients with hypertension (hypertension group, 3 males and 13 females, age range of 41-68 years old), sixteen patients with comorbid hypertension in depression (comorbidity group, 3 males and 13 females, age range of 45-74 years old), and sixteen healthy controls (control group, 3 males and 13 females, age range of 43-68 years old) were recruited. 3D pcASL sequence was performed by GE 3.0T magnetic resonance scanner and CBF map was generated automatically. Statistical parametric mapping (SPM8) was performed to preprocess the CBF map, which was spatially normalized and smoothed. Comparison of the CBF values among the four groups was conducted by ANOVA. Correlation between the average CBF values in areas of decreased CBF and Hamilton depression scale (HAMD-17) was investigated.Results: The patients with comorbid hypertension in depression demonstrated lower CBF in bilateral superior frontal gyri, middle frontal gyri, inferior frontal gyri, right superior parietal gyrus, right inferior parietal gyrus, right supramarginal gyrus, left caudate nucleus and left insula lobe in comparison with the controls. Compared with control group, CBF values decreased in bilateral frontal lobes, but did not reach statistical significance. There were no significant differences of CBF values between the patients with hypertension and control subjects. Compared with depression, the patients with comorbid hypertension in depression showed lower CBF values in bilateral frontal lobes and right supramarginal gyrus. Compared with hypertension, lower CBF values in left middle frontal gyrus in the patients with comorbid hypertension in depression were shown. Correlation analysis indicated that no correlation between CBF values and scores of HAMD-17 was shown.Conclusion: Although there were no significant decreases of CBF values in patients with depression and hypertension, regional hypoperfusions were observed in patients with comorbid hypertension in depression. Hypertension might play a sy-nergistic action on cerebral hypoperfusion in patients with comorbid hypertension in depression.

Key words: Depressive disorder, Hypertension, Arterial spin labeling, Cerebral blood flow

CLC Number: 

  • R814.46

Figure 1

Differences of cerebral blood flow between comorbidity group and control group Difference of cerebral blood flow values in frontal and parietal lobes in patients with comorbid hypertension in depression as compared with healthy control subjects were displayed (3D display)."

Table 1

Decreased CBF values in patients with comorbid hypertension in depression compared to controls"

Cerebral areas CBF values/[mL/(100 g·min)] Peak point MNI
Comorbidity group Control group P value X Y Z F value
Left superior frontal gyrus 46.7±5.7 56.1±11.0 0.004 -30 57 24 19.14
Right superior frontal gyrus 40.4±5.6 50.2±10.3 0.001 33 6 63 22.09
Left middle frontal gyrus 46.3±7.2 55.5±12.0 0.006 -33 54 24 29.89
Right middle frontal gyrus 43.9±6.1 55.4±11.3 0.001 36 3 63 21.69
Left inferior frontal gyrus 47.7±5.7 57.5±9.6 0.001 -48 27 30 23.45
Right inferior frontal gyrus 48.8±5.6 59.2±10.1 0.001 54 15 33 21.99
Right superior parietal gyrus 32.5±4.4 43.7±12.7 0.001 21 -72 54 16.12
Right inferior parietal gyrus 42.6±6.6 53.9±12.7 0.002 54 -30 54 15.59
Right supramarginal gyrus 47.3±5.6 56.8±9.8 0.002 63 -21 45 15.64
Left caudate nucleus 39.1±4.3 46.8±7.4 0.002 -3 9 3 17.47
Left insular lobe 49.3±5.9 62.3±8.7 <0.001 -36 12 6 20.72

Figure 2

Differences of cerebral blood flow between comorbidity group and depression group, comorbidity group and depression group A, compared with depression, patients with comorbid hypertension in depression showed lower CBF values, mainly in bilateral frontal lobes and right supramarginal gyrus; B, compared with hypertension, lower CBF values in left middle frontal gyrus in patients with comorbid hypertension in depression were shown."

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