Email Alert | RSS

Journal of Peking University (Health Sciences) ›› 2022, Vol. 54 ›› Issue (1): 113-118. doi: 10.19723/j.issn.1671-167X.2022.01.018

Previous Articles     Next Articles

Evaluation of bioceramic putty repairmen iRoot and mineral trioxide aggregate in mature permanent teeth pulpotomy

QIAN Kun,PAN Jie,ZHU Wen-hao,ZHAO Xiao-yi,LIU Chang,YONG Wei()   

  1. Department of General Dentistry, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & NHC Research Center of Engineering and Technology for Computerized Dentistry & NMPA Key Laboratory for Dental Materials, Beijing 100081, China
  • Received:2021-09-13 Online:2022-02-18 Published:2022-02-21
  • Contact: Wei YONG E-mail:yongwei1004@sina.com
  • Supported by:
    New Clinical Technology Program of Peking University Hospital and Stomatology(PKUSSNCT-17A14)

RICH HTML

   

PDF (PC)

Abstract:

Objective: To evaluate the clinical characteristics and effectiveness of pulpotomy in mature permanent teeth with bioceramic putty repairmen iRoot and mineral trioxide aggregate (MTA). Methods: Pulpotomy was performed on mature permanent premolars and molars with carious exposures at the Department of General Dentistry of Peking University School and Hospital of Stomatology,from November 2017 to September 2019. The patients were randomly divided into 2 groups, Group iRoot (n=22) and Group MTA (n=21). In Group iRoot, bioceramic putty repairmen iRoot was used as pulp capping agent, while in Group MTA, mineral trioxide aggregate was used as pulp capping agent. All the patients had signed informed consent forms. The clinical efficacy was evaluated by clinical examinations (temperature and electrical activity test) and imaging examinations 3, 6, and 12 months after surgery. Blinding was used for the patients and evaluators, but due to the obvious differences in the properties of the two pulp capping agents, the blinding method was not used for the treatment provider (the attending physician). Results: There was no significant difference in gender, average age, dentition and tooth position distribution between the two groups (P>0.05). In the study, 7 cases were lost to follow-up 12 months after operation (4 cases in Group iRoot, and 3 cases in Group MTA). One case in each of the two groups had transient sensitivity at the end of the 3-month follow-up, and the pulp vitality was normal at the end of the 6-month follow-up. One case in Group iRoot showed sensitivity at the end of the 12-month follow-up. The success rates of the two groups at the end of 12-month follow-up were 100%, and the cure rates were 94.4% (Group iRoot) and 100% (Group MTA), respectively, and the difference was not statistically significant (P>0.05). No cases in Group iRoot had obvious crown discoloration, while 3 cases in Group MTA had. Conclusion: The clinical characteristics and effectiveness of pulpotomy in mature permanent teeth with bioceramic putty repairmen iRoot were similar with MTA. Bioceramic putty repairmen iRoot is an acceptable material when used in pulpotomy of mature permanent teeth. Because it is not easy to cause tooth discoloration after treatment and is convenient to operate, bioceramic putty repairmen iRoot has a better clinical application prospect.

Key words: Pulpotomy, Mature permanent teeth, Bioceramic putty repairmen, Mineral trioxide aggregate

CLC Number: 

  • R781.3

Table 1

Descriptive data"

Items Group iRoot (n=22) Group MTA (n= 21) t/χ2 P value
Gender, n
Male 6 7 0.187 0.665
Female 16 14
Average age/years, M(Min, Max) 30.7 (16, 59) 30.4 (21, 55) 0.093 0.926
Jaw, n
Upper 16 12 1.149 0.284
Lower 6 9
Tooth position, n
Premolar 9 6 0.72 0.396
Molar 13 15

Figure 1

Radiographic findings of a maxillary right first molar after pulpotomy with bioceramic putty repairmen iRoot A, pre-operative radiograph; B, 3-month follow-up radiograph; C, 6-month follow-up radiograph; D, 12-month follow-up radiograph."

Figure 2

Radiographic findings of a maxillary left first molar after pulpotomy with mineral trioxide aggregate A, pre-operative radiograph; B, 3-month follow-up radiograph; C, 6-month follow-up radiograph; D, 24-month follow-up radiograph."

Figure 3

Six-month follow-up clinical photos of mandibular left first molars after pulpotomy A, pulpotomy with mineral trioxide aggregate; B, pulpotomy with bioceramic putty repairmen iRoot."

[1] Duncan HF, Galler KM, Tomson PL, et al. European society of endodontology position statement: management of deep caries and the exposed pulp[J]. Int Endod J, 2019: 52(7):923-934.
doi: 10.1111/iej.13080 pmid: 30664240
[2] 董艳梅. 活髓保存治疗与生物活性盖髓剂的临床现状与研究[J]. 中华口腔医学杂志, 2014, 49(5):268-271.
[3] 高学军, 岳林. 牙体牙髓病学[M]. 北京: 北京大学医学出版社, 2013: 367-368.
[4] Linsuwanont P, Wimonsutthikul K, Pothimoke U, et al. Treatment outcomes of mineral trioxide aggregate pulpotomy in vital permanent teeth with carious pulp exposure: the retrospective study[J]. J Endod, 2017, 43(2):225-230.
doi: S0099-2399(16)30754-3 pmid: 28041685
[5] Taha NA, Khazali MA. Partial pulpotomy in mature permanent teeth with clinical signs indicative of irreversible pulpitis: a randomized clinical trial[J]. J Endod, 2017, 43(9):1417-1421.
doi: 10.1016/j.joen.2017.03.033
[6] 韦曦, 凌均棨. 直接盖髓术的现代理念与临床进展[J]. 中华口腔医学杂志, 2019, 54(9):577-583.
[7] Kulan P, Karabiyik O, Kose GT, et al. The effect of accelerated mineral trioxide aggregate on odontoblastic differentiation in dental pulp stem cell niches[J]. Int Endod J, 2018, 51(7):758-766.
doi: 10.1111/iej.12747 pmid: 28117904
[8] Yoon JH, Choi SH, Koh JT, et al. Hard tissue formation after direct pulp capping with osteostatin and MTA in vivo[J]. Restor Dent Endod, 2021, 46(2):e17.
doi: 10.5395/rde.2021.46.e17
[9] Liu S, Wang S, Dong Y. Evaluation of a bioceramic as a pulp capping agent in vitro and in vivo[J]. J Endod, 2015, 41(5):652-657.
doi: 10.1016/j.joen.2014.12.009
[10] Komabayashi T, Zhu Q, Eberhart R, et al. Current status of direct pulp-capping materials for permanent teeth[J]. Dent Mater J, 2016, 35(1):1-12.
doi: 10.4012/dmj.2015-013 pmid: 26830819
[11] Mahgoub N, Alqadasi B, Aldhorae K, et al. Comparison between iRoot BP Plus (EndoSequence root repair material) and mineral trioxide aggregate as pulp-capping agents: a systematic review[J]. J Int Soc Prev Community Dent, 2019, 9(6):542-552.
doi: 10.4103/jispcd.JISPCD_249_19 pmid: 32039073
[12] Asgary S, Hassanizadeh R, Torabzadeh H, et al. Treatment outcomes of 4 vital pulp therapies in mature molars[J]. J Endod, 2018, 44(4):529-535.
doi: S0099-2399(17)31301-8 pmid: 29397215
[13] Taha NA, Ahmad MB, Ghanim A. Assessment of mineral trioxide aggregate pulpotomy in mature permanent teeth with carious exposures[J]. Int Endod J, 2017, 50(2):117-125.
doi: 10.1111/iej.12605 pmid: 26715408
[14] Shi S, Bao ZF, Liu Y, et al. Comparison of in vivo dental pulp responses to capping with iRoot BP Plus and mineral trioxide aggregate[J]. Int Endod J, 2016, 49(2):154-160.
doi: 10.1111/iej.12439 pmid: 25661049
[15] Parirokh M, Torabinejad M, Dummer PMH. Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview-part Ⅰ: vital pulp therapy[J]. Int Endod J, 2018, 51(2):177-205.
doi: 10.1111/iej.12841 pmid: 28836288
[16] Javid B, Panahandeh N, Torabzadeh H, et al. Bioactivity of endodontic biomaterials on dental pulp stem cells through dentin[J]. Restor Dent Endod, 2019, 45(1):e3.
doi: 10.5395/rde.2020.45.e3
[17] Liu Y, Liu XM, Bi J, et al. Cell migration and osteo/odontogenesis stimulation of iRoot FS as a potential apical barrier material in apexification[J]. Int Endod J, 2020, 53(4):467-477.
doi: 10.1111/iej.13237 pmid: 31622505
[18] Lu J, Li Z, Wu X, et al. iRoot BP Plus promotes osteo/odontogenic differentiation of bone marrow mesenchymal stem cells via MAPK pathways and autophagy[J]. Stem Cell Res Ther, 2019, 10(1):222.
doi: 10.1186/s13287-019-1345-3
[19] ElReash AA, Hamama H, Eldars W, et al. Antimicrobial activity and pH measurement of calcium silicate cements versus new bioactive resin composite restorative material[J]. BMC Oral Health, 2019, 19(1):235.
doi: 10.1186/s12903-019-0933-z pmid: 31684929
[20] Öncel Torun Z, Torun D, Demirkaya K, et al. Effects of iRoot BP and white mineral trioxide aggregate on cell viability and the expression of genes associated with mineralization[J]. Int Endodontic J, 2015, 48(10):986-993.
doi: 10.1111/iej.2015.48.issue-10
[21] Zhang J, Zhu LX, Cheng X, et al. Promotion of dental pulp cell migration and pulp repair by a bioceramic putty involving FGFR-mediated signaling pathways[J]. J Dent Res, 2015, 94(6):853-862.
doi: 10.1177/0022034515572020 pmid: 25724555
[22] Peskersoy C, Lukarcanin J, Turkun M. Efficacy of different cal-cium silicate materials as pulp-capping agents: randomized clinical trial[J]. J Dent Sci, 2021, 16(2):723-731.
doi: 10.1016/j.jds.2020.08.016 pmid: 33854725
[23] Qudeimat MA, Barrieshi-Nusair KM, Owais AI. Calcium hydro-xide vs. mineral trioxide aggregates for partial pulpotomy of permanent molars with deep caries[J]. Eur Arch Paediatr Dent, 2007, 8(2):99-104.
doi: 10.1007/BF03262577
[24] Kang C, Kim S, Shin Y, et al. A randomized controlled trial of ProRoot MTA, OrthoMTA and RetroMTA for pulpotomy in primary molars[J]. Oral Dis, 2015, 21(6):785-791.
doi: 10.1111/odi.12348 pmid: 25970794
[25] 丁美丽, 秦满, 郑佳佳, 等. 新型生物陶瓷材料用于年轻恒牙牙髓切断术的效果评价[J]. 口腔医学研究, 2018, 34(7):766-770.
[26] Yang Y, Xia B, Xu Z, et al. The effect of partial pulpotomy with iRoot BP Plus in traumatized immature permanent teeth: a rando-mized prospective controlled trial[J]. Dent Traumatol, 2020, 36(5):518-525.
[27] 雷玥, 杨颖婷, 战园. 生物陶瓷材料在乳牙牙髓切断术中的应用[J]. 北京大学学报(医学版), 2019, 51(1):70-74.
[28] Azimi S, Fazlyab M, Sadri D, et al. Comparison of pulp response to mineral trioxide aggregate and a bioceramic paste in partial pulpotomy of sound human premolars: a randomized controlled trial[J]. Int Endod J, 2014, 47(9):873-881.
doi: 10.1111/iej.12231 pmid: 24330490
[29] Zanini M, Hennequin M, Cousson PY. A review of criteria for the evaluation of pulpotomy outcomes in mature permanent teeth[J]. J Endod, 2016, 42(8):1167-1174.
doi: 10.1016/j.joen.2016.05.008
[30] Simon S, Perard M, Zanini M, et al. Should pulp chamber pulpotomy be seen as a permanent treatment? Some preliminary thoughts[J]. Int Endod J, 2013, 46(1):79-87.
doi: 10.1111/j.1365-2591.2012.02113.x pmid: 22900881
[31] Kunert GG, Kunert IR, da Costa Filho LC, et al. Permanent teeth pulpotomy survival analysis: retrospective follow-up[J]. J Dent, 2015, 43(9):1125-1131.
doi: 10.1016/j.jdent.2015.06.010
[32] Mass E, Zilberman U. Long-term radiologic pulp evaluation after partial pulpotomy in young permanent morlars[J]. Quintessence Int, 2011, 42(7):547-554.
[1] Jiajia ZHENG,Xue YANG,Quan WEN,Yuan FU,Xiao SHAO,Meili DING. Application of bioactive ceramics iRoot BP Plus® in pulpotomy for complicated crown fracture of immature permanent anterior teeth in children [J]. Journal of Peking University (Health Sciences), 2024, 56(1): 179-184.
[2] Xiaoyi ZHAO,Chang LIU,Kun QIAN,Jie PAN. Efficacy and radiology evaluation of pulpotomy in mature permanent teeth [J]. Journal of Peking University (Health Sciences), 2024, 56(1): 138-143.
[3] Wei YONG,Kun QIAN,Wen-hao ZHU,Xiao-yi ZHAO,Chang LIU,Jie PAN. X-ray evaluation of pulp calcification in adult permanent teeth after pulpotomy [J]. Journal of Peking University (Health Sciences), 2023, 55(1): 88-93.
[4] Shuang WANG,Chu-fang PENG,He LIU. Pulpotomy of human primary molars with novel bioceramic material [J]. Journal of Peking University (Health Sciences), 2022, 54(6): 1196-1201.
[5] Bing-qing SHI,Xiao-jing YUAN,Yu-ming ZHAO. Effects of mineral trioxide aggregate and ethanolic extracts of Shandong propolis on the biological properties of human dental pulp fibroblasts [J]. Journal of Peking University(Health Sciences), 2019, 51(6): 1108-1114.
[6] Yue LEI,Ying-ting YANG,Yuan ZHAN. Evaluation of bioceramic putty repairment in primary molars pulpotomy [J]. Journal of Peking University(Health Sciences), 2019, 51(1): 70-74.
[7] LI Shuang, ZHANG Qing. Effect of smear layer on apical sealing ability of mineral trioxide aggregate (MTA) Plus through the sucrose penetration mode [J]. Journal of Peking University(Health Sciences), 2018, 50(3): 560-563.
[8] DOU Gui-li， WU Nan, ZHAO Shuang-yun, XIA Bin. Two-year outcomes of pulpotomy in primary molars using mineral trioxide aggregate: a retrospective study [J]. Journal of Peking University(Health Sciences), 2018, 50(1): 170-175.
[9] GUO Yi-dan, ZHANG Sun. Preliminary research of Er:YAG laser used for pulpotomy of Beagle dogs [J]. Journal of Peking University(Health Sciences), 2016, 48(4): 714-719.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Journal of Peking University(Health Sciences), 2007, 39(3): 225 -328 .
[2] . [J]. Journal of Peking University(Health Sciences), 2007, 39(5): 498 -502 .
[3] . [J]. Journal of Peking University(Health Sciences), 2000, 32(4): 300 .
[4] . [J]. Journal of Peking University(Health Sciences), 2001, 33(6): 559 -561 .
[5] . [J]. Journal of Peking University(Health Sciences), 2001, 33(6): 565 .
[6] . [J]. Journal of Peking University(Health Sciences), 2008, 40(1): 39 -42 .
[7] . [J]. Journal of Peking University(Health Sciences), 2008, 40(6): 600 -602 .
[8] . [J]. Journal of Peking University(Health Sciences), 2009, 41(5): 537 -540 .
[9] . [J]. Journal of Peking University(Health Sciences), 2009, 41(1): 90 -94 .
[10] . [J]. Journal of Peking University(Health Sciences), 2003, 35(4): 382 -385 .
Copyright © Journal of Peking University (Health Sciences), All Rights Reserved.
Powered by Beijing Magtech Co. Ltd