Journal of Peking University(Health Sciences) ›› 2016, Vol. 48 ›› Issue (2): 203-209. doi: 10.3969/j.issn.1671-167X.2016.02.004

• Article • Previous Articles     Next Articles

Intraarticular injection of bevacizumab in treatment of osteoarthritis: a laboratory research on a rabbit model

LI Wei1, JIANG Chun-yan2△, WANG Zhan-wei1, XIAO De-ming1   

  1. (1. Department of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong, China; 2. Department of Sports Medicine, Beijing Jishuitan Hospital, Beijing 100035, China)
  • Online:2016-04-18 Published:2016-04-18
  • Contact: JIANG Chun-yan E-mail:chunyanj@hotmail.com
  • Supported by:

    Supported by the Commission on Technology and Innovation of Shen-zhen (JCYJ20130402113802232)

Abstract:

Objective:To evaluate the effects of intraarticular injection of bevacizumab、sodium hyalu-ronate (SH) and 0.9% sodium chloride injection in the treatment of osteoarthritis (OA) in a rabbit model. Methods: Twenty-four male rabbits were randomly divided into bevacizumab group,SH group and control group after the model of OA had been made. The bevacizumab group and control group received intraarticular bevacizumab (4 mg) and 0.9% saline injection respectively once per three weeks for 2 times. The SH group received intraarticular SH once a week for 6 weeks. After 6 weeks, the histological examinations of cartilage and synovium,electron microscopy and expression of vasculan endothelial growth factorl (VEGF), for the synovium, expression of MMP-1, Mankin’s scale, macroscopic observation for cartilage were performed. Results: The histological observation of the bevacizumab group and the SH group showed that bevacizumab could decrease the synoviocytes and inhibit fibrous hyperplasia in synovial underlayer compard with the control group. Reduced apoptosis of chondrocytes and more integrated structure of matrix and more glycosaminoglycan were also found in the bevacizumab group and the SH group compared with control group. The expression of VEGF and MMP-1, Mankin’s scale, macroscopic observation were significantly decreased in the bevacizumab group compared with the SH group and the control group (P<0.05). Conclusion: Intraarticular injection of bevacizumab and SH can relieve inflammation of OA and alleviate the pathologic process of OA. The Bevacizumab was better than the SH in therapeutic effect, which maybe implicate a better choice for the treatment of OA.

Key words: Osteoarthritis, Synovitis, Bevacizumab, Injection, intra-articular, Models, animal

CLC Number: 

  • R684.3
[1] Hongguang LI,Weihua HAN,Xun WU,Jiling FENG,Gang LI,Juanhong MENG. Preliminarily study of arthrocentesis combined with liquid phase concentrated growth factor injection in the treatment of unilateral temporomandibular joint osteoarthritis [J]. Journal of Peking University (Health Sciences), 2024, 56(2): 338-344.
[2] Hao WU,Li-ping PAN,Heng LIU,Hong-bin WANG,Tai-guo NING,Yong-ping CAO. Effect of posterior tibial slope on the short-term outcome in mobile-bearing unicompartmental knee arthroplasty [J]. Journal of Peking University (Health Sciences), 2021, 53(5): 877-882.
[3] WU Jun-hui,CHEN Hong-bo,WU Yi-qun,WU Yao,WANG Zi-jing,WU Tao,WANG Meng-ying,WANG Si-yue,WANG Xiao-wen,WANG Jia-ting,YU Huan,HU Yong-hua. Prevalence and risk factors of osteoarthritis in patients with type 2 diabetes in Beijing, China from 2015 to 2017 [J]. Journal of Peking University (Health Sciences), 2021, 53(3): 518-522.
[4] KE Yan,ZHANG Qiang,MA Yun-qing,LI Ru-jun,TAO Ke,GUI Xian-ge,LI Ke-peng,ZHANG Hong,LIN Jian-hao. Short-term outcomes of total hip arthroplasty in the treatment of Tönnis grade 3 hip osteoarthritis in patients with spondyloepiphyseal dysplasia [J]. Journal of Peking University (Health Sciences), 2021, 53(1): 175-182.
[5] Jia-jing PENG,Tian LIU. Rheumatoid arthritis combined with pigmented villonodular synovitis: A case report and literature review [J]. Journal of Peking University (Health Sciences), 2020, 52(6): 1135-1139.
[6] Xiao-ying ZHANG,Jia-jing PENG,Chuan-hui LIU,Xiao-yan CAI,Jiang-lin ZHANG,Yi-fang MEI,Hong-tao JIN,Xiao-fei WANG,Hong MO,Zhan-guo LI. A multi-center cross-sectional survey of medicine application in patients with osteoarthritis in China [J]. Journal of Peking University(Health Sciences), 2018, 50(6): 1044-1048.
[7] WANG Dan-dan, GAN Ye-hua, MA Xu-chen, MENG Juan-hong. Association between ADAMTS14 gene polymorphism and the temporomandibular joint osteoarthritis in Chinese Han females [J]. Journal of Peking University(Health Sciences), 2018, 50(2): 279-283.
[8] MENG Juan-hong, GUO Yu-xing, LUO Hai-yan, GUO Chuan-bin, MA Xu-chen. Diagnosis and treatment of diffuse tenosynovial giant cell tumor arising from temporomandibular joints [J]. Journal of Peking University(Health Sciences), 2016, 48(6): 1049-1054.
[9] LI Zhi-chang, JIANG Long, ZHANG Shu, QIN Xue-ying, Daniel K. White PT,HOU Yun-fei, ZHOU Zhi-wei, LIN Jian-hao. Evaluation of physical function for the end-stage osteoarthritis patient waiting for the total knee replacement [J]. Journal of Peking University(Health Sciences), 2016, 48(2): 257-262.
[10] PAN Li-ping, CAO Yong-ping, WEN Li-cheng, CHAI Wei-bing, DU Jun-bao, JIN Hong-fang, LIU Jia, YANG Xin, MENG Zhi-chao, LIU Heng, CUI Yun-peng, WANG Rui, WU Hao, ZHOU Xing-tong, LI Xiang. Hydrogen sulfide in cartilage and its inhibitory effect on matrix metalloproteinase 13 expression in chondrocytes induced  by interlukin-1β [J]. Journal of Peking University(Health Sciences), 2016, 48(2): 194-201.
[11] ZHU Yi-Ming, JIANG Chun-Yan, LU Yi, LI Feng-Long, LI Xu, LI Yue. Clinical follow-up study after open Latarjet procedure in patients with recurrent anterior shoulder dislocation [J]. Journal of Peking University(Health Sciences), 2015, 47(2): 226-231.
[12] CUI Yun-Peng, CAO Yong-Ping, LIU Heng, YANG Xin, MENG Zhi-Chao, WANG Rui. Bone marrow mesenchymal stem cells in Sprague-Dawley rat model of osteoarthritis [J]. Journal of Peking University(Health Sciences), 2015, 47(2): 211-218.
[13] WANG Cheng, ZHAO Ran, ZHANG Guo-An. Pathological changes in different parts of the larynx in canines following laryngeal burns induced by inhalation of hot air at various temperatures [J]. Journal of Peking University(Health Sciences), 2014, 46(5): 771-776.
[14] LIU Heng, CAO Yong-Ping, CUI Yun-Peng, YANG Xin, MENG Zhi-Chao, WANG Rui. Effect of mitochondrial dysfunction of chondrocyte on cartilage degeneration [J]. Journal of Peking University(Health Sciences), 2014, 46(5): 760-765.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!