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Journal of Peking University (Health Sciences) ›› 2021, Vol. 53 ›› Issue (3): 518-522. doi: 10.19723/j.issn.1671-167X.2021.03.013

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Prevalence and risk factors of osteoarthritis in patients with type 2 diabetes in Beijing, China from 2015 to 2017

WU Jun-hui1,CHEN Hong-bo1,2,WU Yi-qun1,WU Yao1,WANG Zi-jing1,WU Tao1,WANG Meng-ying1,WANG Si-yue1,WANG Xiao-wen1,WANG Jia-ting1,YU Huan1,HU Yong-hua1,Δ()   

  1. 1. Department of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China
    2. Department of Geriatric Nursing and Rehabilitation, Peking University School of Nursing, Beijing 100191, China
  • Received:2021-03-01 Online:2021-06-18 Published:2021-06-16
  • Contact: Yong-hua HU E-mail:yhhu@bjmu.edu.cn
  • Supported by:
    National Natural Science Foundation of China(81230066);National Natural Science Foundation of China(81473043);National Natural Science Foundation of China(81703291);National Natural Science Foundation of China(81872695)

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Abstract:

Objective: To explore the prevalence and related factors of osteoarthritis in patients with type 2 diabetes mellitus, and provided a scientific basis for the prevention of the comorbidity. Methods: The data were obtained from the database of all designated medical institutions in Beijing from 2015 to 2017. Data of the adult patients with type 2 diabetes mellitus were collected for descriptive analysis, and a Logistic regression model was used to explore the related factors of osteoarthritis in the patients with type 2 diabetes mellitus. Results: A total of 1 046 264 diagnosed type 2 diabetes mellitus adult patients were included in our study, with an average age of 63.07 years, and 50.78% were males. Among the patients with type 2 diabetes mellitus, there were 341 561 cases with osteoarthritis, and the prevalence of osteoarthritis was 32.65%. The prevalence of females (38.05%) was higher than that of males (27.41%), and the difference was statistically significant (P<0.05). Osteoarthritis occurred in all age groups among the patients with type 2 diabetes mellitus, with the highest prevalence of osteoarthritis in the age group of 65-69 years (36.76%), and the lowest prevalence in the age group ≤44 years (14.3%). Before the age of 70, the prevalence increased with age. Further analysis of related factors for osteoarthritis in the patients with type 2 diabetes mellitus showed that female (OR=1.62, 95%CI: 1.61-1.63), age (OR=1.01, 95%CI: 1.01-1.01), had other comorbidities (OR=1.19, 95%CI: 1.18-1.21), used hypoglycemic drugs (OR=0.79, 95%CI: 0.78-0.80), having the cardiovascular disease (OR=1.13, 95%CI: 1.11-1.15), having cerebrovascular disease (OR=1.25, 95%CI: 1.23-1.28), and having nephropathy (OR=1.61, 95%CI: 1.51-1.71) were associated with the osteoarthritis in the type 2 diabetic mellitus patients. Conclusion: Our study revealed that the prevalence of osteoarthritis in patients with type 2 diabetes mellitus is high in Beijing area. Health education and disease monitoring should be strengthened in middle-aged and elderly patients. Screening for comorbidities should be carried out as soon as possible, with the focus on menopausal women.

Key words: Diabetes mellitus,type 2, Osteoarthritis, Comorbidity, Prevalence

CLC Number: 

  • R181.3

Table 1

Characteristics of adult type 2 diabetes patients in Beijing from 2015 to 2017"

Characteristics With osteoarthritis(n=341 561) Without osteoarthritis(n=704 703) Total(n=1 046 264)
n % n % n %
Gender
Male 145 615 42.63 385 722 54.74 531 337 50.78
Female 195 946 57.37 318 981 45.26 514 927 49.22
Age group
≤44 years 13 407 3.93 61 650 8.75 75 057 7.17
45-54 years 48 873 14.31 121 812 17.29 170 685 16.31
55-64 years 120 204 35.19 228 786 32.47 348 990 33.36
65-74 years 82 241 24.08 142 097 20.16 224 338 21.44
≥75 years 76 836 22.50 150 358 21.34 227 194 21.71
Comorbidity
Yes 40 387 11.82 94 502 13.41 134 889 12.89
No 301 174 88.18 610 201 86.59 911 375 87.11
Use of hypoglycemic drugs
Yes 257 246 75.31 501 560 71.17 758 806 72.53
No 84 315 24.69 203 143 28.83 287 458 27.47

Figure 1

Prevalence of osteoarthritis in type 2 diabetes mellitus in different age groups"

Table 2

Prevalence of other comorbidities in patients with type 2 diabetes combined with osteoarthritis in Beijing from 2015 to 2017 (%)"

Characteristics Age group Total
≤44 years 45-54 years 55-64 years 65-74 years ≥75 years
Cardiovascular disease 7.70 14.57 18.40 24.52 35.36 22.72
Cerebrovascular disease 5.65 9.12 11.02 15.07 24.62 14.57
Nephropathy 3.07 1.62 1.31 1.49 1.72 1.56
Eye diseases 0.97 0.65 0.66 0.68 0.48 0.64

Table 3

Multivariate Logistic regression analysis of osteoarthritis related factors in adult type 2 diabetes patients in Beijing from 2015 to 2017"

Variable Model 1 Model 2 Model 3
OR 95%CI P OR 95%CI P OR 95%CI P
Female 1.63 1.62-1.65 <0.01 1.62 1.61-1.63 <0.01 1.62 1.61-1.63
Age 1.01 1.01-1.02 <0.01 1.02 1.01-1.02 <0.01 1.01 1.01-1.02 <0.01
Comorbidity 1.19 1.18-1.21 <0.01
Use of hypoglycemic drugs 0.79 0.78-0.80 <0.01
Cardiovascular disease 1.13 1.11-1.15 <0.01
Cerebrovascular disease 1.25 1.23-1.28 <0.01
Eye diseases 1.03 0.94-1.13 0.44
Nephropathy 1.61 1.51-1.71 <0.01
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