Email Alert | RSS

Journal of Peking University (Health Sciences) ›› 2021, Vol. 53 ›› Issue (3): 518-522. doi: 10.19723/j.issn.1671-167X.2021.03.013

Previous Articles     Next Articles

Prevalence and risk factors of osteoarthritis in patients with type 2 diabetes in Beijing, China from 2015 to 2017

WU Jun-hui1,CHEN Hong-bo1,2,WU Yi-qun1,WU Yao1,WANG Zi-jing1,WU Tao1,WANG Meng-ying1,WANG Si-yue1,WANG Xiao-wen1,WANG Jia-ting1,YU Huan1,HU Yong-hua1,Δ()   

  1. 1. Department of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China
    2. Department of Geriatric Nursing and Rehabilitation, Peking University School of Nursing, Beijing 100191, China
  • Received:2021-03-01 Online:2021-06-18 Published:2021-06-16
  • Contact: Yong-hua HU E-mail:yhhu@bjmu.edu.cn
  • Supported by:
    National Natural Science Foundation of China(81230066);National Natural Science Foundation of China(81473043);National Natural Science Foundation of China(81703291);National Natural Science Foundation of China(81872695)

RICH HTML

   

PDF (PC)

Abstract:

Objective: To explore the prevalence and related factors of osteoarthritis in patients with type 2 diabetes mellitus, and provided a scientific basis for the prevention of the comorbidity. Methods: The data were obtained from the database of all designated medical institutions in Beijing from 2015 to 2017. Data of the adult patients with type 2 diabetes mellitus were collected for descriptive analysis, and a Logistic regression model was used to explore the related factors of osteoarthritis in the patients with type 2 diabetes mellitus. Results: A total of 1 046 264 diagnosed type 2 diabetes mellitus adult patients were included in our study, with an average age of 63.07 years, and 50.78% were males. Among the patients with type 2 diabetes mellitus, there were 341 561 cases with osteoarthritis, and the prevalence of osteoarthritis was 32.65%. The prevalence of females (38.05%) was higher than that of males (27.41%), and the difference was statistically significant (P<0.05). Osteoarthritis occurred in all age groups among the patients with type 2 diabetes mellitus, with the highest prevalence of osteoarthritis in the age group of 65-69 years (36.76%), and the lowest prevalence in the age group ≤44 years (14.3%). Before the age of 70, the prevalence increased with age. Further analysis of related factors for osteoarthritis in the patients with type 2 diabetes mellitus showed that female (OR=1.62, 95%CI: 1.61-1.63), age (OR=1.01, 95%CI: 1.01-1.01), had other comorbidities (OR=1.19, 95%CI: 1.18-1.21), used hypoglycemic drugs (OR=0.79, 95%CI: 0.78-0.80), having the cardiovascular disease (OR=1.13, 95%CI: 1.11-1.15), having cerebrovascular disease (OR=1.25, 95%CI: 1.23-1.28), and having nephropathy (OR=1.61, 95%CI: 1.51-1.71) were associated with the osteoarthritis in the type 2 diabetic mellitus patients. Conclusion: Our study revealed that the prevalence of osteoarthritis in patients with type 2 diabetes mellitus is high in Beijing area. Health education and disease monitoring should be strengthened in middle-aged and elderly patients. Screening for comorbidities should be carried out as soon as possible, with the focus on menopausal women.

Key words: Diabetes mellitus,type 2, Osteoarthritis, Comorbidity, Prevalence

CLC Number: 

  • R181.3

Table 1

Characteristics of adult type 2 diabetes patients in Beijing from 2015 to 2017"

Characteristics With osteoarthritis(n=341 561) Without osteoarthritis(n=704 703) Total(n=1 046 264)
n % n % n %
Gender
Male 145 615 42.63 385 722 54.74 531 337 50.78
Female 195 946 57.37 318 981 45.26 514 927 49.22
Age group
≤44 years 13 407 3.93 61 650 8.75 75 057 7.17
45-54 years 48 873 14.31 121 812 17.29 170 685 16.31
55-64 years 120 204 35.19 228 786 32.47 348 990 33.36
65-74 years 82 241 24.08 142 097 20.16 224 338 21.44
≥75 years 76 836 22.50 150 358 21.34 227 194 21.71
Comorbidity
Yes 40 387 11.82 94 502 13.41 134 889 12.89
No 301 174 88.18 610 201 86.59 911 375 87.11
Use of hypoglycemic drugs
Yes 257 246 75.31 501 560 71.17 758 806 72.53
No 84 315 24.69 203 143 28.83 287 458 27.47

Figure 1

Prevalence of osteoarthritis in type 2 diabetes mellitus in different age groups"

Table 2

Prevalence of other comorbidities in patients with type 2 diabetes combined with osteoarthritis in Beijing from 2015 to 2017 (%)"

Characteristics Age group Total
≤44 years 45-54 years 55-64 years 65-74 years ≥75 years
Cardiovascular disease 7.70 14.57 18.40 24.52 35.36 22.72
Cerebrovascular disease 5.65 9.12 11.02 15.07 24.62 14.57
Nephropathy 3.07 1.62 1.31 1.49 1.72 1.56
Eye diseases 0.97 0.65 0.66 0.68 0.48 0.64

Table 3

Multivariate Logistic regression analysis of osteoarthritis related factors in adult type 2 diabetes patients in Beijing from 2015 to 2017"

Variable Model 1 Model 2 Model 3
OR 95%CI P OR 95%CI P OR 95%CI P
Female 1.63 1.62-1.65 <0.01 1.62 1.61-1.63 <0.01 1.62 1.61-1.63
Age 1.01 1.01-1.02 <0.01 1.02 1.01-1.02 <0.01 1.01 1.01-1.02 <0.01
Comorbidity 1.19 1.18-1.21 <0.01
Use of hypoglycemic drugs 0.79 0.78-0.80 <0.01
Cardiovascular disease 1.13 1.11-1.15 <0.01
Cerebrovascular disease 1.25 1.23-1.28 <0.01
Eye diseases 1.03 0.94-1.13 0.44
Nephropathy 1.61 1.51-1.71 <0.01
[1] Hunter DJ, Bierma-Zeinstra S. Osteoarthritis[J]. Lancet, 2019,393(10182):1745-1759.
doi: S0140-6736(19)30417-9 pmid: 31034380
[2] Hunter DJ, Schofield D, Callander E. The individual and socio-economic impact of osteoarthritis[J]. Nat Rev Rheumatol, 2014,10(7):437-441.
doi: 10.1038/nrrheum.2014.44 pmid: 24662640
[3] Neogi T. The epidemiology and impact of pain in osteoarthritis[J]. Osteoarthritis Cartilage, 2013,21(9):1145-1153.
doi: 10.1016/j.joca.2013.03.018
[4] 王华军, 陈均源, 罗斯敏, 等. 糖尿病与骨关节炎相关性的Meta分析[J]. 中国矫形外科杂志, 25(11):994-998.
[5] Veronese N, Cooper C, Reginster JY, et al. Type 2 diabetes mellitus and osteoarthritis[J]. Semin Arthritis Rheum, 2019,49(1):9-19.
doi: 10.1016/j.semarthrit.2019.01.005
[6] Asfandiyarova NS, Nizov AA, Nekhaeva TI, et al. Osteoarthrosis in patients with type 2 diabetes mellitus[J]. Terapevticheski Arkhiv, 2013,85(5):44.
[7] 刘爱武, 王秋萍, 杜娜, 等. 住院患者2型糖尿病与膝骨关节炎流行病学的研究[J]. 中国社区医师, 2019,35(9):165-169.
[8] 曾雁冰, 袁志鹏, 方亚. 中国老年人就医行为及其影响因素研究[J]. 中国卫生统计, 2020,37(2):199-205.
[9] Liu Y, Zhang HF, Liang NX. Prevalence and associated factors of knee osteoarthritis in a rural Chinese adult population: An epidemiological survey[J]. BMC Public Health, 2015,16(1):94.
doi: 10.1186/s12889-016-2782-x
[10] Lee SG, Kim SJ. Prevalence of knee osteoarthritis, risk factors, and quality of life: the Fifth Korean National Health and Nutrition Examination Survey[J]. Int J Rheum Dis, 2017,20(7):809-817.
doi: 10.1111/apl.2017.20.issue-7
[11] Nieves-Plaza M, Castro-Santana LE, Font YM, et al. Association of hand or knee osteoarthritis with diabetes mellitus in a population of Hispanics from Puerto Rico[J]. J Clin Rheumatol, 2013,19(1):1-6.
doi: 10.1097/RHU.0b013e31827cd578 pmid: 23319016
[12] Prieto-Alhambra D, Judge A, Javaid MK, et al. Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: Influences of age, gender and osteoarthritis affecting other joints[J]. Ann Rheum Dis, 2014,73(9):1659-1664.
doi: 10.1136/annrheumdis-2013-203355
[13] Rosa SC, Goncalves J, Judas F, et al. Impaired glucose trans-porter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteo-arthritic versus normal human cartilage[J]. Arthritis Res Ther, 2009,11(3):R80.
doi: 10.1186/ar2713
[14] Courties A, Sellam J. Osteoarthritis and type 2 diabetes mellitus: What are the links?[J]. Diabetes Res Clin Pract, 2016,122:198-206.
doi: 10.1016/j.diabres.2016.10.021
[15] Findlay DM. Vascular pathology and osteoarthritis[J]. Rheumatology (Oxford), 2007,46(12):1763-1768.
pmid: 17693442
[16] Johnson EO, Soultanis K, Soucacos PN. Vascular anatomy and microcirculation of skeletal zones vulnerable to osteonecrosis: Vascularization of the femoral head[J]. Orthop Clin North Am, 2004,35(3):285-291.
doi: 10.1016/j.ocl.2004.03.002
[1] Yuanyuan ZENG,Yun XIE,Daonan CHEN,Ruilan WANG. Related factors of euthyroid sick syndrome in patients with sepsis [J]. Journal of Peking University (Health Sciences), 2024, 56(3): 526-532.
[2] Hongguang LI,Weihua HAN,Xun WU,Jiling FENG,Gang LI,Juanhong MENG. Preliminarily study of arthrocentesis combined with liquid phase concentrated growth factor injection in the treatment of unilateral temporomandibular joint osteoarthritis [J]. Journal of Peking University (Health Sciences), 2024, 56(2): 338-344.
[3] Yong-wei LIN,Ya-lin ZHOU,Run-long ZHAO,Ya-jun XU,Yan-ping LIU. Analysis on the iron status and associated factors during the first trimester of pregnancy [J]. Journal of Peking University (Health Sciences), 2023, 55(4): 600-605.
[4] Qiang FU,Guan-ying GAO,Yan XU,Zhuo-hua LIN,You-jing SUN,Li-gang CUI. Comparative study of ultrasound and magnetic resonance imaging in the diagnosis of asymptomatic anterosuperior acetabular labrum tears [J]. Journal of Peking University (Health Sciences), 2023, 55(4): 665-669.
[5] Hao WU,Li-ping PAN,Heng LIU,Hong-bin WANG,Tai-guo NING,Yong-ping CAO. Effect of posterior tibial slope on the short-term outcome in mobile-bearing unicompartmental knee arthroplasty [J]. Journal of Peking University (Health Sciences), 2021, 53(5): 877-882.
[6] KE Yan,ZHANG Qiang,MA Yun-qing,LI Ru-jun,TAO Ke,GUI Xian-ge,LI Ke-peng,ZHANG Hong,LIN Jian-hao. Short-term outcomes of total hip arthroplasty in the treatment of Tönnis grade 3 hip osteoarthritis in patients with spondyloepiphyseal dysplasia [J]. Journal of Peking University (Health Sciences), 2021, 53(1): 175-182.
[7] Yan GENG,Zhi-bo SONG,Xiao-hui ZHANG,Xue-rong DENG,Yu WANG,Zhuo-li ZHANG. Depression and anxiety in patients with psoriatic arthritis: Prevalence and associated factors [J]. Journal of Peking University (Health Sciences), 2020, 52(6): 1048-1055.
[8] Si-wei DENG,Ze-yi CHEN,Zhi-ke LIU,Jian WANG,Lin ZHUO,Shuang-qing GAO,Jia-kuo YU,Si-yan ZHAN. Epidemiological study of bone and joint injury based on urban medical insurance database [J]. Journal of Peking University (Health Sciences), 2020, 52(3): 527-534.
[9] Lu XU,Lu CHEN,Dong-sheng FAN,Jing-nan FENG,Li-li LIU,Si-yan ZHAN,Sheng-feng WANG. Calculation of the prevalence of progressive muscular atrophy among adults in China based on urban medical insurance data from 15 provinces [J]. Journal of Peking University (Health Sciences), 2020, 52(3): 521-526.
[10] Xiao-ying ZHANG,Jia-jing PENG,Chuan-hui LIU,Xiao-yan CAI,Jiang-lin ZHANG,Yi-fang MEI,Hong-tao JIN,Xiao-fei WANG,Hong MO,Zhan-guo LI. A multi-center cross-sectional survey of medicine application in patients with osteoarthritis in China [J]. Journal of Peking University(Health Sciences), 2018, 50(6): 1044-1048.
[11] WANG Dan-dan, GAN Ye-hua, MA Xu-chen, MENG Juan-hong. Association between ADAMTS14 gene polymorphism and the temporomandibular joint osteoarthritis in Chinese Han females [J]. Journal of Peking University(Health Sciences), 2018, 50(2): 279-283.
[12] SHI Hui-feng, ZHANG Jing-xu, ZHANG Rong, WANG Xiao-li. Prevalence of autism spectrum disorders in children aged 0-6 years in China: a meta-analysis [J]. Journal of Peking University(Health Sciences), 2017, 49(5): 798-806.
[13] LI Zhi-chang, JIANG Long, ZHANG Shu, QIN Xue-ying, Daniel K. White PT,HOU Yun-fei, ZHOU Zhi-wei, LIN Jian-hao. Evaluation of physical function for the end-stage osteoarthritis patient waiting for the total knee replacement [J]. Journal of Peking University(Health Sciences), 2016, 48(2): 257-262.
[14] LI Wei, JIANG Chun-yan， WANG Zhan-wei, XIAO De-ming. Intraarticular injection of bevacizumab in treatment of osteoarthritis： a laboratory research on a rabbit model [J]. Journal of Peking University(Health Sciences), 2016, 48(2): 203-209.
[15] PAN Li-ping, CAO Yong-ping, WEN Li-cheng, CHAI Wei-bing, DU Jun-bao, JIN Hong-fang, LIU Jia, YANG Xin, MENG Zhi-chao, LIU Heng, CUI Yun-peng, WANG Rui, WU Hao, ZHOU Xing-tong, LI Xiang. Hydrogen sulfide in cartilage and its inhibitory effect on matrix metalloproteinase 13 expression in chondrocytes induced  by interlukin-1β [J]. Journal of Peking University(Health Sciences), 2016, 48(2): 194-201.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright © Journal of Peking University (Health Sciences), All Rights Reserved.
Powered by Beijing Magtech Co. Ltd