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Journal of Peking University (Health Sciences) ›› 2024, Vol. 56 ›› Issue (4): 693-699. doi: 10.19723/j.issn.1671-167X.2024.04.024

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Association between serum uric acid and airflow obstruction based on the health-checkup population

Qingxin ZHOU,Qingqing YANG,Shuyuan SHI,Pei LI,Feng SUN*()   

  1. Department of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China
  • Received:2021-02-23 Online:2024-08-18 Published:2024-07-23
  • Contact: Feng SUN E-mail:sunfeng@bjmu.edu.cn

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Abstract:

Objective: To investigate the association between serum uric acid, pulmonary function and airflow obstruction in Chinese Taiwan healthy subjects. Methods: All the cross-sectional analysis was performed in the population over 40 years old using the physical examination data of Chinese Taiwan MJ Health Resource Center between 1996 and 2016 stratification by gender. The correlation analyses between serum uric acid were done and multivariate Logistic regression analysis was used to explore the effect of serum uric acid on airflow obstruction. Results: A total of 35 465 people were included in the study, including 16 411 men and 19 054 women. Among them, the serum uric acid concentration of men was higher than that of women, and the serum uric acid concentration of the people with airflow obstruction was higher than that of the people without airflow obstruction. There was a negative correlation between serum uric acid level and the forced expiratory volume in one second (FEV1) and the force vital capacity (FVC) in women (P < 0.05), but in men the correlation didn' t exist (P>0.05). After adjusting for age, education, smoking status, drinking status, work strength, body mass index, history of cough, history of hypertension, history of diabetes, history of dyslipidemia, white blood cells and blood albumin, the airflow obstruction in women was more likely to exist with the serum uric acid elevated (OR=1. 12, 95%CI: 1.02-1.22, P < 0.05). The results showed that women with hyperuricemia were more likely to have airflow obstruction than those without hyperuricemia (OR=1.36, 95%CI: 1.06-1.75, P < 0.05). There was no correlation between serum uric acid concentration and airflow obstruction in men (OR=1.04, 95%CI: 0.96-1.13, P>0.05), also the hyperuricemia and airflow obstruction (OR=1.12, 95%CI: 0.89-1.39, P>0.05). Conclusion: There is a negative correlation between serum uric acid and FEV1 and FVC in relatively healthy women, and there is an association between elevated serum uric acid and airflow obstruction in women, but not in men. Further prospective studies are needed to explore whether high serum uric acid level can increase the risk of airflow obstruction.

Key words: Uric acid, Respiratory function tests, Chronic obstructive pulmonary disease, Cross-sectional study

CLC Number: 

  • R181.3

Table 1

Baseline characteristics of the study subjects"

ItemsMen Women
Normal group (n=15 905) Airflow obstruction group(n=506) P value Normal group(n=18 536) Airflow obstruction group(n=518) P value
Age/years 45.40±7.37 51.50±9.56 ＜0.001 45.60±7.02 50.90±8.52 ＜0.001
Marriage status 0.002 ＜0.001
  Unmarried 626 (4.14) 11 (2.26) 1 124 (6.41) 15 (3.02)
  Married 14 035 (92.70) 448 (92.20) 14 657 (83.60) 403 (81.20)
  Divorce/widowed 478 (3.16) 27 (5.56) 1 744 (9.95) 78 (15.70)
Education ＜0.001 ＜0.001
  High school and below 5 743 (37.20) 305 (61.90) 9 786 (54.40) 390 (77.20)
  High school and above 9 700 (62.80) 188 (38.10) 8 217 (45.60) 115 (22.80)
Smoking status 0.001 0.203
  Never 8 099 (52.80) 205 (44.00) 16 558 (95.10) 431 (96.60)
  Passive smoking 1 853 (12.10) 69 (14.80) 167 (0.96) 1 (0.22)
  Current smoking 5 380 (35.10) 192 (41.20) 690 (3.96) 14 (3.14)
Working strength ＜0.001 0.007
  Mild 9 128 (59.80) 233 (50.70) 11 598 (65.60) 277 (58.30)
  Moderate 3 783 (24.80) 120 (26.10) 4 790 (27.10) 159 (33.50)
  Severe 1 847 (12.10) 82 (17.80) 1 169 (6.61) 34 (7.16)
  Extremely severe 494 (3.24) 25 (5.43) 127 (0.72) 5 (1.05)
Hypertension 3 137 (19.70) 142 (28.10) ＜0.001 2 528 (13.60) 118 (22.80) ＜0.001
Diabetes 771 (4.85) 37 (7.31) 0.016 530 (2.86) 26 (5.02) 0.006
Hyperlipidemia 11 733 (73.80) 384 (75.90) 0.309 9 547 (51.50) 341 (65.80) ＜0.001
Obesity 5 992 (37.70) 175 (34.60) 0.172 3 800 (20.50) 151 (29.20) ＜0.001
Frequent cough 1 669 (11.40) 85 (19.30) ＜0.001 1 528 (8.91) 75 (16.40) ＜0.001
FEV1/L 3.54±0.40 3.29±0.44 ＜0.001 2.58±0.28 2.39±0.29 ＜0.001
FVC/L 4.32±0.48 4.05±0.50 ＜0.001 3.15±0.32 2.95±0.32 0.123
WBC/(×103/μL) 6.38±1.63 6.73±1.65 ＜0.001 5.85±1.51 6.17±1.46 ＜0.001
FBG/(mg/dL) 102±19.40 103±25.90 0.527 97.00±16.90 98.70±23.50 0.098
HDLC/(mg/dL) 47.9±12.50 46.30±13.40 0.009 59.40±15.40 55.20±15.40 ＜0.001
LDLC/(mg/dL) 127±32.00 130±34.60 0.133 117±32.00 127±32.90 ＜0.001
GFR/[mL/(min·1.73 m2)] 82.40±12.90 78.30±13.10 ＜0.001 87.70±14.60 83.90±14.80 ＜0.001
Triglycerides/(mg/dL) 145.00±99.60 136.00±87.00 0.025 98.70±66.00 113.00±78.90 ＜0.001
Albumin/(g/dL) 4.54±0.24 4.59±0.28 ＜0.001 4.42±0.24 4.50±0.26 ＜0.001
ALT/(IU/L) 24.80±12.70 24.60±9.94 0.704 21.00±16.90 23.10±25.40 0.070
AST/(IU/L) 32.40±26.00 29.10±17.80 ＜0.001 20.60±26.20 22.90±30.60 0.087
Creatinine/(mg/dL) 1.08±0.15 1.10±0.16 0.009 0.81±0.12 0.83±0.13 0.001
Serum uric acid/(mg/dL) 6.65±1.30 6.76±1.43 0.065 4.93±1.20 5.35±1.40 ＜0.001
Hyperuricemia 5 660 (35.60) 207 (40.90) 0.016 2 954 (15.90) 147 (28.40) ＜0.001
Kidney injury 1 267 (7.97) 62 (12.30) 0.001 999 (5.39) 44 (8.49) 0.003

Figure 1

Correlation between serum uric acid and pulmonary function indicators FEV1 and FVC A and B, the correlation between serum uric acid level and FEV1 and FVC in men; C and D, the correlation between serum uric acid level and FEV1 and FVC in women. Abbreviations as in Table 1."

Table 2

Multivariate Logistic regression analysis of serum uric acid, hyperuricemia and airflow obstruction"

ItemsModel 1 Model 2 Model 3 Model 4 Model 5
OR (95%CI) P value OR (95%CI) P value OR (95%CI) P value OR (95%CI) P value OR (95%CI) P value
Men
  Serum uric acid 1.07 (1.00-1.15) 0.040 1.05 (0.98-1.13) 0.158 1.06 (0.98-1.15) 0.160 1.07 (0.98-1.16) 0.120 1.04 (0.96-1.13) 0.305
  Hyperuricemia 1.23 (1.03-1.48) 0.025 1.16 (0.95-1.42) 0.158 1.15 (0.92-1.43) 0.216 1.16 (0.93-1.45) 0.184 1.12 (0.89-1.39) 0.342
Women
  Serum uric acid 1.07 (1.00-1.15) 0.040 1.09 (1.00-1.19) 0.044 1.14 (1.04-1.24) 0.003 1.14 (1.05-1.25) 0.002 1.12 (1.02-1.22) 0.016
  Hyperuricemia 1.41 (1.15-1.73) 0.001 1.43 (1.13-1.79) 0.003 1.43 (1.12-1.83) 0.004 1.45 (1.13-1.86) 0.003 1.36 (1.06-1.75) 0.016

Figure 2

Association between serum uric acid and airflow obstruction A, the correlation between serum uric acid and airflow obstruction in men. B, the correlation between serum uric acid and airflow obstruction in women. The model adjusted for age, education, smoking status, drinking, working strength, body mass index, frequent cough, history of hypertension, history of diabetes, history of dyslipidemia, history of kidney injury, albumin, white blood cells, and liver function."

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