北京大学学报（医学版） ›› 2024, Vol. 56 ›› Issue (4): 557-561. doi: 10.19723/j.issn.1671-167X.2024.04.001
• 述评 • 下一篇
治疗相关神经内分泌前列腺癌机制研究与靶向治疗新进展
黄教悌1,*(
),胡菁2,3,韩博2,4
- 1 Department of Pathology, Duke University, Durham, NC 27710, USA
2 山东大学齐鲁医院病理科，济南 250012
3 Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48105, USA
4 北京大学人民医院病理科，北京 100044
教悌 黄1,*(),菁 胡2,3,博 韩2,4
中图分类号:
- R737.25
| 1 |
Hu J , Sun F , Chen W , et al. BTF3 sustains cancer stem-like phenotype of prostate cancer via stabilization of BMI1[J]. J Exp Clin Cancer Res, 2019, 38 (1): 227.
doi: 10.1186/s13046-019-1222-z |
| 2 |
Harris WP , Mostaghel EA , Nelson PS , et al. Androgen deprivation therapy: Progress in understanding mechanisms of resistance and optimizing androgen depletion[J]. Nat Clin Pract Urol, 2009, 6 (2): 76- 85.
doi: 10.1038/ncpuro1296 |
| 3 |
Helpap B , Kollermann J , Oehler U . Neuroendocrine differentiation in prostatic carcinomas: Histogenesis, biology, clinical relevance, and future therapeutical perspectives[J]. Urol Int, 1999, 62 (3): 133- 138.
doi: 10.1159/000030376 |
| 4 |
Vlachostergios PJ , Puca L , Beltran H . Emerging variants of castration-resistant prostate cancer[J]. Curr Oncol Rep, 2017, 19 (5): 32.
doi: 10.1007/s11912-017-0593-6 |
| 5 |
Aggarwal R , Huang J , Alumkal JJ , et al. Clinical and genomic characterization of treatment-emergent small-cell neuroendocrine prostate cancer: A multi-institutional prospective study[J]. J Clin Oncol, 2018, 36 (24): 2492- 2503.
doi: 10.1200/JCO.2017.77.6880 |
| 6 |
陈铌, 周桥. 第5版WHO前列腺肿瘤分类解读[J]. 中华病理学杂志, 2023, 52 (4): 321- 328.
doi: 10.3760/cma.j.cn112151-20221208-01030 |
| 7 |
Lee JK , Phillips JW , Smith BA , et al. N-Myc drives neuroendocrine prostate cancer initiated from human prostate epithelial cells[J]. Cancer Cell, 2016, 29 (4): 536- 547.
doi: 10.1016/j.ccell.2016.03.001 |
| 8 |
Han M , Li F , Zhang Y , et al. FOXA2 drives lineage plasticity and KIT pathway activation in neuroendocrine prostate cancer[J]. Cancer Cell, 2022, 40 (11): 1306- 1323.e8.
doi: 10.1016/j.ccell.2022.10.011 |
| 9 |
Wang Z , Wang T , Hong D , et al. Single-cell transcriptional regulation and genetic evolution of neuroendocrine prostate cancer[J]. iScience, 2022, 25 (7): 104576.
doi: 10.1016/j.isci.2022.104576 |
| 10 |
Hu J , Han B , Huang J . Morphologic spectrum of neuroendocrine tumors of the prostate: An updated review[J]. Arch Pathol Lab Med, 2020, 144 (3): 320- 325.
doi: 10.5858/arpa.2019-0434-RA |
| 11 |
Ali A , Du Feu A , Oliveira P , et al. Prostate zones and cancer: Lost in transition?[J]. Nat Rev Urol, 2022, 19 (2): 101- 115.
doi: 10.1038/s41585-021-00524-7 |
| 12 | Soares VA , Trezza E . Electrocardiographic changes observed during the use of trimethaphan in the treatment of malignant arterial hypertension[J]. Arq Bras Cardiol, 1978, 31 (4): 273- 276. |
| 13 |
Ousset M , van Keymeulen A , Bouvencourt G , et al. Multipotent and unipotent progenitors contribute to prostate postnatal development[J]. Nat Cell Biol, 2012, 14 (11): 1131- 1138.
doi: 10.1038/ncb2600 |
| 14 |
Choi N , Zhang B , Zhang L , et al. Adult murine prostate basal and luminal cells are self-sustained lineages that can both serve as targets for prostate cancer initiation[J]. Cancer Cell, 2012, 21 (2): 253- 265.
doi: 10.1016/j.ccr.2012.01.005 |
| 15 |
Stoyanova T , Cooper AR , Drake JM , et al. Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells[J]. Proc Natl Acad Sci USA, 2013, 110 (50): 20111- 20116.
doi: 10.1073/pnas.1320565110 |
| 16 |
Park JW , Lee JK , Sheu KM , et al. Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage[J]. Science, 2018, 362 (6410): 91- 95.
doi: 10.1126/science.aat5749 |
| 17 |
Ku SY , Rosario S , Wang Y , et al. Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance[J]. Science, 2017, 355 (6320): 78- 83.
doi: 10.1126/science.aah4199 |
| 18 |
Deng S , Wang C , Wang Y , et al. Ectopic JAK-STAT activation enables the transition to a stem-like and multilineage state conferring AR-targeted therapy resistance[J]. Nat Cancer, 2022, 3 (9): 1071- 1087.
doi: 10.1038/s43018-022-00431-9 |
| 19 |
Giafaglione JM , Crowell PD , Delcourt AML , et al. Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment[J]. Nat Cell Biol, 2023, 25 (12): 1821- 1832.
doi: 10.1038/s41556-023-01274-x |
| 20 |
Bakht MK , Beltran H . Metabolically regulated lineages in prostate cancer[J]. Nat Cell Biol, 2023, 25 (12): 1726- 1728.
doi: 10.1038/s41556-023-01298-3 |
| 21 |
Butler W , Xu L , Zhou Y , et al. Oncofetal protein glypican-3 is a biomarker and critical regulator of function for neuroendocrine cells in prostate cancer[J]. J Pathol, 2023, 260 (1): 43- 55.
doi: 10.1002/path.6063 |
| 22 |
Kaushik AK , Shojaie A , Panzitt K , et al. Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer[J]. Nat Commun, 2016, 7, 11612.
doi: 10.1038/ncomms11612 |
| 23 |
Graham LS , Haffner MC , Sayar E , et al. Clinical, pathologic, and molecular features of amphicrine prostate cancer[J]. Prostate, 2023, 83 (7): 641- 648.
doi: 10.1002/pros.24497 |
| 24 |
Labrecque MP , Coleman IM , Brown LG , et al. Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer[J]. J Clin Invest, 2019, 129 (10): 4492- 4505.
doi: 10.1172/JCI128212 |
| 25 |
Labrecque MP , Brown LG , Coleman IM , et al. RNA splicing factors SRRM3 and SRRM4 distinguish molecular phenotypes of castration-resistant neuroendocrine prostate cancer[J]. Cancer Res, 2021, 81 (18): 4736- 4750.
doi: 10.1158/0008-5472.CAN-21-0307 |
| 26 |
Wilkinson S , Ye H , Karzai F , et al. Nascent prostate cancer heterogeneity drives evolution and resistance to intense hormonal therapy[J]. Eur Urol, 2021, 80 (6): 746- 757.
doi: 10.1016/j.eururo.2021.03.009 |
| 27 |
Cheng Q , Butler W , Zhou Y , et al. Pre-existing castration-resistant prostate cancer-like cells in primary prostate cancer promote resistance to hormonal therapy[J]. Eur Urol, 2022, 81 (5): 446- 455.
doi: 10.1016/j.eururo.2021.12.039 |
| 28 |
Marklund M , Schultz N , Friedrich S , et al. Spatio-temporal analysis of prostate tumors in situ suggests pre-existence of treatment-resistant clones[J]. Nat Commun, 2022, 13 (1): 5475.
doi: 10.1038/s41467-022-33069-3 |
| 29 |
Dong B , Miao J , Wang Y , et al. Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer[J]. Commun Biol, 2020, 3 (1): 778.
doi: 10.1038/s42003-020-01476-1 |
| 30 |
Deeble PD , Murphy DJ , Parsons SJ , et al. Interleukin-6- and cyclic AMP-mediated signaling potentiates neuroendocrine differentiation of LNCaP prostate tumor cells[J]. Mol Cell Biol, 2001, 21 (24): 8471- 8482.
doi: 10.1128/MCB.21.24.8471-8482.2001 |
| 31 |
Wang C , Peng G , Huang H , et al. Blocking the feedback loop between neuroendocrine differentiation and macrophages improves the therapeutic effects of enzalutamide (MDV3100) on prostate cancer[J]. Clin Cancer Res, 2018, 24 (3): 708- 723.
doi: 10.1158/1078-0432.CCR-17-2446 |
| 32 |
Natani S , Sruthi KK , Asha SM , et al. Activation of TGF-beta: SMAD2 signaling by IL-6 drives neuroendocrine differentiation of prostate cancer through p38MAPK[J]. Cell Signal, 2022, 91, 110240.
doi: 10.1016/j.cellsig.2021.110240 |
| 33 |
Huang J , Yao JL , Zhang L , et al. Differential expression of interleukin-8 and its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate cancer[J]. Am J Pathol, 2005, 166 (6): 1807- 1815.
doi: 10.1016/S0002-9440(10)62490-X |
| 34 |
Li Y , He Y , Butler W , et al. Targeting cellular heterogeneity with CXCR2 blockade for the treatment of therapy-resistant prostate cancer[J]. Sci Transl Med, 2019, 11 (521): eaax0428.
doi: 10.1126/scitranslmed.aax0428 |
| 35 |
Lim J S , Ibaseta A , Fischer MM , et al. Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer[J]. Nature, 2017, 545 (7654): 360- 364.
doi: 10.1038/nature22323 |
| 36 |
Beltran H , Oromendia C , Danila DC , et al. A phase Ⅱ trial of the aurora kinase a inhibitor alisertib for patients with castration-resistant and neuroendocrine prostate cancer: Efficacy and biomarkers[J]. Clin Cancer Res, 2019, 25 (1): 43- 51.
doi: 10.1158/1078-0432.CCR-18-1912 |
| 37 |
Michaelson MD , Oudard S , Ou YC , et al. Randomized, placebo-controlled, phase Ⅲ trial of sunitinib plus prednisone versus prednisone alone in progressive, metastatic, castration-resistant prostate cancer[J]. J Clin Oncol, 2014, 32 (2): 76- 82.
doi: 10.1200/JCO.2012.48.5268 |
| 38 |
Shimizu Y , Suzuki T , Yoshikawa T , et al. Next-generation cancer immunotherapy targeting glypican-3[J]. Front Oncol, 2019, 9, 248.
doi: 10.3389/fonc.2019.00248 |
| 39 |
Paz-Ares L , Champiat S , Lai WV , et al. Tarlatamab, a first-in-class DLL3-targeted bispecific T-cell engager, in recurrent small-cell lung cancer: An open-label, phase Ⅰ study[J]. J Clin Oncol, 2023, 41 (16): 2893- 2903.
doi: 10.1200/JCO.22.02823 |
| 40 |
Yang W , Wang W , Li Z , et al. Delta-like ligand 3 in small cell lung cancer: Potential mechanism and treatment progress[J]. Crit Rev Oncol Hematol, 2023, 191, 104136.
doi: 10.1016/j.critrevonc.2023.104136 |
| 41 |
Giffin MJ , Cooke K , Lobenhofer EK , et al. AMG 757, a half-life extended, DLL3-targeted bispecific T-cell engager, shows high potency and sensitivity in preclinical models of small-cell lung cancer[J]. Clin Cancer Res, 2021, 27 (5): 1526- 1537.
doi: 10.1158/1078-0432.CCR-20-2845 |
| 42 |
Chou J , Egusa EA , Wang S , et al. Immunotherapeutic targeting and PET imaging of DLL3 in small-cell neuroendocrine prostate cancer[J]. Cancer Res, 2023, 83 (2): 301- 315.
doi: 10.1158/0008-5472.CAN-22-1433 |
| 43 |
Gay CM , Stewart CA , Park EM , et al. Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities[J]. Cancer Cell, 2021, 39 (3): 346- 360.e7.
doi: 10.1016/j.ccell.2020.12.014 |
| [1] | 尤柱,徐丽莉,李雪芬,张建运,杜菁,孙丽莎. 成釉细胞纤维瘤中BRAF突变基因的检测[J]. 北京大学学报（医学版）, 2019, 51(1): 4-5. |
|
||
