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北京大学学报（医学版） ›› 2024, Vol. 56 ›› Issue (1): 4-8. doi: 10.19723/j.issn.1671-167X.2024.01.002

• 获奖工作综述 • 上一篇    下一篇

口腔硬组织修复材料仿生设计制备和临床转化

赵菡1,卫彦2,张学慧3,杨小平4,蔡晴4,宁成云5,徐明明2,刘雯雯2,黄颖2,何颖2,郭亚茹2,江圣杰2,白云洋2,吴宇佳2,郭雨思2,郑晓娜2,李文静2,邓旭亮2,*()   

  1. 1. 北京大学口腔医学院·口腔医院综合科，国家口腔医学中心，国家口腔疾病临床医学研究中心，口腔生物材料和数字诊疗装备国家工程研究中心，国家药品监督管理局口腔材料重点实验室，北京 100081
    2. 北京大学口腔医学院·口腔医院特诊科，国家口腔医学中心，国家口腔疾病临床医学研究中心，口腔生物材料和数字诊疗装备国家工程研究中心，国家药品监督管理局口腔材料重点实验室，北京 100081
    3. 北京大学口腔医学院·口腔医院材料研究室，国家口腔医学中心，国家口腔疾病临床医学研究中心，口腔生物材料和数字诊疗装备国家工程研究中心，国家药品监督管理局口腔材料重点实验室，北京 100081
    4. 北京化工大学材料科学与工程学院生物材料系，有机无机复合材料国家重点实验室，生物医用材料北京实验室，北京，100029
    5. 华南理工大学材料科学与工程学院生物材料系，国家人体组织功能重建工程技术研究中心，广东省生物医学工程重点实验室，广州 510641
  • 收稿日期:2023-11-27 出版日期:2024-02-18 发布日期:2024-02-06
  • 通讯作者: 邓旭亮 E-mail:kqdengxuliang@bjmu.edu.cn
  • 基金资助:
    国家自然科学基金创新研究群体科学基金(82221003);国家自然科学基金重大项目(81991505);国家重点研发计划(2018YFC1105300);国家杰出青年科学基金(81425007);国家杰出青年科学基金(82225012);国家高技术研究发展计划(863计划)(2011AA030102)

Bionic design, preparation and clinical translation of oral hard tissue restorative materials

Han ZHAO1,Yan WEI2,Xuehui ZHANG3,Xiaoping YANG4,Qing CAI4,Chengyun NING5,Mingming XU2,Wenwen LIU2,Ying HUANG2,Ying HE2,Yaru GUO2,Shengjie JIANG2,Yunyang BAI2,Yujia WU2,Yusi GUO2,Xiaona ZHENG2,Wenjing LI2,Xuliang DENG2,*()   

  1. 1. Department of General Dentistry, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & NMPA Key Laboratory for Dental Materials, Beijing 100081, China
    2. Department of Geriatric Dentistry, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & NMPA Key Laboratory for Dental Materials, Beijing 100081, China
    3. Department of Dental Materials, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & NMPA Key Laboratory for Dental Materials, Beijing 100081, China
    4. College of Materials Science and Engineering, State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China
    5. School of Materials Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, Guangdong Key Laboratory of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou 510006, China
  • Received:2023-11-27 Online:2024-02-18 Published:2024-02-06
  • Contact: Xuliang DENG E-mail:kqdengxuliang@bjmu.edu.cn
  • Supported by:
    the Science Fund for Creative Research Groups of the National Natural Science Foundation of China(82221003);the Major Program of National Natural Science Foundation of China(81991505);the National Key Research and Development Program of China(2018YFC1105300);the National Science Fund for Distinguished Young Scholars(81425007);the National Science Fund for Distinguished Young Scholars(82225012);the National High Technology Research and Development Program of China (863 Program)(2011AA030102)

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关键词: 牙齿修复材料, 骨组织引导再生膜, 电学微环境, 骨充填材料, 生物力学

Abstract:

Oral diseases concern almost every individual and are a serious health risk to the population. The restorative treatment of tooth and jaw defects is an important means to achieve oral function and support the appearance of the contour. Based on the principle of "learning from the nature", Deng Xuliang's group of Peking University School and Hospital of Stomatology has proposed a new concept of "microstructural biomimetic design and tissue adaptation of tooth/jaw materials" to address the worldwide problems of difficulty in treating dentine hypersensitivity, poor prognosis of restoration of tooth defects, and vertical bone augmentation of alveolar bone after tooth loss. The group has broken through the bottleneck of multi-stage biomimetic technology from the design of microscopic features to the enhancement of macroscopic effects, and invented key technologies such as crystalline/amorphous multi-level assembly, ion-transportation blocking, and multi-physical properties of the micro-environment reconstruction, etc. The group also pioneered the cationic-hydrogel desensitizer, digital stump and core integrated restorations, and developed new crown and bridge restorative materials, gradient functionalisation guided tissue regeneration membrane, and electrically responsive alveolar bone augmentation restorative membranes, etc. These products have established new clinical strategies for tooth/jaw defect repair and achieved innovative results. In conclusion, the research results of our group have strongly supported the theoretical improvement of stomatology, developed the technical system of oral hard tissue restoration, innovated the clinical treatment strategy, and led the progress of the stomatology industry.

Key words: Dental restoration materials, Guided bone regeneration membranes, Electrical microenvironment, Bone filling materials, Biomechanics

中图分类号: 

  • R781.05
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ISSN 1671-167X
CN 11-4691/R
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