Journal of Peking University(Health Sciences) ›› 2014, Vol. 46 ›› Issue (5): 744-750.

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Preparation and investigation of MRI-traceable Eudragit-E liquid embolic agent

LIU Ying-ying1, LU Xiao-jing1, ZHENG Zhuo-zhao2, GUAN Hai-tao3, FU Nai-qi2, LV Tian-shi 3, ZHANG Shui-sheng3, SONG Li3, ZOU Ying-hua3, FAN Tian-yuan1△   

  1. (1. Department of Pharmaceutics, Peking University School of Pharmaceutical Sciences, Beijing 100191, China; 2. Department of Radiology, Peking University Third Hospital, Beijing 100191, China; 3. Department of Interventional Radiology and Vascular Surgery, Peking University First Hospital, Beijing 100034, China)
  • Online:2014-10-18 Published:2014-10-18

Abstract: Objective:To develop and investigate the properties of MRI-traceable Eudragit-E liquid embolic agent (MR-E). Methods: Polyethylene glycol-modified superparamagnetic iron oxides (PEG-SPIO) was synthesized by chemical co-precipitation method. MR-E was prepared by mixing PEG-SPIO and Eudragit-E liquid embolic agent homogeneously. An in vitro MR phantom study was carried out to measure MR traceability of MR-E and to determine the concentration of PEG-SPIO for further studies. The microcatheter deliverability and sol-gel transition process of MR-E were investigated. MR-E was injected into the kidney of a Japanese white big ear rabbit via an angiographic microcatheter, and detected by MRI. Results: A PEG-SPIO concentration of 2 g/L was considered to be suitable for further studies. MR-E was injected through the microcatheter without any difficulty. MR-E instantly solidified on release into saline. Then 0.2 mL of MR-E effectively embolized distal renal arteries, and MR-E could be detected by MRI in the embolized kidney. Conclusion: MR-E seems to be a promising MRI-traceable liquid embolic agent.

Key words: Embolization,therapeutic, Liquid embolic agent, Magnetic resonance imaging, Ferric oxide

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