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Journal of Peking University (Health Sciences) ›› 2025, Vol. 57 ›› Issue (3): 620-625. doi: 10.19723/j.issn.1671-167X.2025.03.030

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朱慧1, 闵赛南1, 苏家增1, 陈艳2, 彭歆1, 于尧1, 俞光岩1,*()   

  • Received:2024-02-05 Online:2025-06-18 Published:2025-06-13
  • Contact: 俞光岩

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  • R781.5

Table 1

Clinical features of 6 cases with eosinophilic ulcer of the oral mucosa"

Case Gender Age/years Duration/weeks Location Range/(cm×cm) Etiology EO(×109/L) Clinical impression Management Follow-up/months Recurrence Times of other ulcers*
1 M 30 1 The dorsum of the tongue 2.0×1.5 Stab 1.66↑ Malignant tumor？ Resection 12 No 3
2 F 60 12 Lateral margin of the tongue 1.5×1.0 Psychological 0.03 Malignant tumor Biopsy 24 No 2
3 M 10 4 Buccal mucosa 2.0×2.0 None - Malignant tumor Biopsy 66 No 0
4 F 57 2 Lateral margin of the tongue 1.5×1.0 None - Malignant tumor Biopsy 54 No 0
5 M 0.5 8 The belly of the tongue 1.5×1.0 Incisor rubbing 0.85↑ Tumor？ Resection 42 No 4
6 M 49 1.5 Lateral margin of the tongue 4.0×3.0 Bite 0.07 Tumor or infection？ Biopsy 11 No 0

Figure 1

Case 1, an ulcer on the dorsum of the tongue, which is covered with pseudomembrane and surrounded by elevated lesion"

Figure 2

Case 1, CT showed a mildly enhanced round soft tissue mass on the dorsum of the tongue(arrowhead)"

Figure 3

Case 1, the lesion is excised, and the wound is closed by direct suture"

Figure 4

Histopathological findings of case 1 A, ulcer on the surface of mucosa with neutrophil infiltration (HE ×20); B, chronic inflammatory cells including many eosinophilic cells diffusely infiltrate into the muscle (HE ×40)."

Figure 5

Case 2, an ulcer on the lateral margin of the right tongue A, appearance of ulcer at the initial diagnosis; B, one week after biopsy, the lesion is smaller than before; C, one month later, the ulcer in the anterior part of the right lingual margin disappeared, and an ulcer appeared in the posterior part of the right lingual margin with rough surface; D, one year later, a mung bean-sized ulcer appeared(arrowhead)."

Figure 6

Histopathological findings of case 2 A, ulcer on the surface of mucosa with epithelial necrosis, inflammatory cells infiltration in the underlying submucosa (HE ×20); B, mixed chronic inflammatory cell infiltration in the submucosa and muscle，note the presence of many eosinophilic cells (HE ×40)."

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