Journal of Peking University(Health Sciences) ›› 2014, Vol. 46 ›› Issue (3): 355-359.

• Articles • Previous Articles     Next Articles

Association of rs2228314 polymorphism in SREBP2 with serum lipid levels and obesity among children and adolescents

LIU Fang-hong, SONG Jie-yun, MA Jun, SHANG Xiao-rui, MENG Xiang-rui, WANG Hai-jun△   

  1. (Department of Child, Adolescent and Women’s Health, Peking University School of Public Health; Institute of Child and Adolescent Health of Peking University, Beijing 100191, China)
  • Online:2014-06-18 Published:2014-06-18

Abstract: Objective:To study the relationship between rs2228314 polymorphism in sterol regulatory element binding protein 2 gene (SREBP2) and obesity, serum lipid levels in children and adolescents. Methods: In our study, 2 030 children and adolescents aged from 7 to 18 years participated. Anthropometric measurements, including height and weight, were performed. Their serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were detected. The matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was used to detect rs2228314 genotypes. Results: The GC/CC genotypes of rs2228314 polymorphisms had lower HDL-C levels than GG genotype [(0.10±0.35) mmol/L vs. (0.14±0.36) mmol/L, P=0.020]. The rs2228314 polymorphism was associated with the abnormal HDL-C level under the dominant model after adjustment for study samples, sex and age (OR=1.400, 95% CI: 1.027-1.907, P=0.033). The rs2228314 polymorphism was not associated with obesity under the dominant model after adjustment for study samples, sex, age and HDLC level (OR=1.178,95% CI: 0.971-1.430, P=0.096). Conclusion: The GC/CC genotype carriers of SREBP2 rs2228314 polymorphism have higher risk of abnormal HDL-C level than the individuals with GG genotype among children and adolescents.

Key words: Sterol regulatory element binding protein 2, Polymorphism, genetic, Obesity, Dyslipidemias, Child  

[1] Jing CHEN,Rui SHAN,Wucai XIAO,Xiaorui ZHANG,Zheng LIU. Association between self-control and co-occurrence of depressive symptoms and overweight or obesity during adolescence and early adulthood: A ten-year prospective cohort study based on national surveys [J]. Journal of Peking University (Health Sciences), 2024, 56(3): 397-402.
[2] Chu-yun CHEN,Peng-fei SUN,Jing ZHAO,Jia JIA,Fang-fang FAN,Chun-yan WANG,Jian-ping LI,Yi-meng JIANG,Yong HUO,Yan ZHANG. Related factors of endogenous erythropoietin and its association with 10-year risks of cardiovascular disease in a community-based Chinese study [J]. Journal of Peking University (Health Sciences), 2023, 55(6): 1068-1073.
[3] Jia-jia DANG,Shan CAI,Pan-liang ZHONG,Ya-qi WANG,Yun-fei LIU,Di SHI,Zi-yue CHEN,Yi-hang ZHANG,Pei-jin HU,Jing LI,Jun MA,Yi SONG. Association of outdoor artificial light at night exposure with overweight and obesity among children and adolescents aged 9 to 18 years in China [J]. Journal of Peking University (Health Sciences), 2023, 55(3): 421-428.
[4] Jing CHEN,Wu-cai XIAO,Rui SHAN,Jie-yun SONG,Zheng LIU. Influence of rs2587552 polymorphism of DRD2 gene on the effect of a childhood obesity intervention: A prospective, parallel-group controlled trial [J]. Journal of Peking University (Health Sciences), 2023, 55(3): 436-441.
[5] Tao MA,Yan-hui LI,Man-man CHEN,Ying MA,Di GAO,Li CHEN,Qi MA,Yi ZHANG,Jie-yu LIU,Xin-xin WANG,Yan-hui DONG,Jun MA. Associations between early onset of puberty and obesity types in children: Based on both the cross-sectional study and cohort study [J]. Journal of Peking University (Health Sciences), 2022, 54(5): 961-970.
[6] Xiao-yuan ZHANG,Cheng-cheng GUO,Ying-xiang YU,Lan XIE,Cui-qing CHANG. Establishment of high-fat diet-induced obesity and insulin resistance model in rats [J]. Journal of Peking University (Health Sciences), 2020, 52(3): 557-563.
[7] Xiao-na NA,Zhu ZHU,Yang-yang CHEN,Dong-ping WANG,Hao-jie WANG,Yang SONG,Xiao-chuan MA,Pei-yu WANG,Ai-ping LIU. Associations of distribution of time spent in physical activity and sedentary behavior with obesity [J]. Journal of Peking University (Health Sciences), 2020, 52(3): 486-491.
[8] Cheng-cheng GUO,Xiao-yuan ZHANG,Ying-xiang YU,Lan XIE,Cui-qing CHANG. Effects of chlorogenic acid on glucose tolerance and its curve characteristics in high-fat diet-induced obesity rats [J]. Journal of Peking University (Health Sciences), 2020, 52(2): 269-274.
[9] DONG Yan-hui, SONG Yi, DONG Bin, ZOU Zhi-yong, WANG Zheng-he, YANG Zhao-geng, WANG Xi-jie, LI Yan-hui, MA Jun. Association between the blood pressure status and nutritional status among Chinese students aged 7-18 years in 2014: based on the national blood pressure reference for Chinese children and adolescents [J]. Journal of Peking University(Health Sciences), 2018, 50(3): 422-428.
[10] WU Yu-jia, CHI Xiao-pei, CHEN Feng, DENG Xu-liang. Salivary microbiome in people with obesity: a pilot study [J]. Journal of Peking University(Health Sciences), 2018, 50(1): 5-12.
[11] ZHOU Jing, ZHOU Qian, WANG Dong-ping, ZHAGN Ting, WANG Hao-jie, SONG Yang, HE Hai-zhen, WANG Meng, WANG Pei-yu, LIU Ai-ping. Associations of sedentary behavior and physical activity with dyslipidemia [J]. Journal of Peking University(Health Sciences), 2017, 49(3): 418-423.
[12] DU Yi-qing, LIU Hui-xin, LIU Chun-lei, DUN Yao-jun, LI Qing, YU Lu-ping, LIU Shi-jun, CHEN Li-li, WANG Xiao-feng, XU Tao. Analysis of metabolic factors and relevance with the grade and stage in patients with renal cell carcinoma [J]. Journal of Peking University(Health Sciences), 2016, 48(4): 612-617.
[13] GAO Ying, ZHU Cheng-gang, WU Na-qiong, GUO Yuan-lin, LIU Geng, DONG Qian, LI Jian-jun. Study on the reliability of CardioChek PA for measuring lipid profile [J]. Journal of Peking University(Health Sciences), 2016, 48(3): 523-528.
[14] CHENG Lan, LI Qin, SONG Yi, MA Jun, WANG Hai-Jun. Association of physical activities, sedentary behaviors with overweight/obesity in 9-11 year-old Chinese primary school students [J]. Journal of Peking University(Health Sciences), 2016, 48(3): 436-441.
[15] FU Lian-Guo, WANG Hai-Jun, YANG Yi-De, LI Xiao-Hui, WANG Shuo, MENG Xiang-Kun, WANG Zheng-He, MA Jun. Analysis on awareness of obesity risk factors among children and adolescents [J]. Journal of Peking University(Health Sciences), 2015, 47(3): 410-413.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!