Abstract:

Hemophilia A is aninherited bleeding disorder, lack of coagulation factor Ⅷ (FⅧ), and if combined with intracranial malignant tumor, the operation risk is very high. Department of Pediatric Surgery in Peking University First Hospital used coagulation factor replacement therapy, succeeded in the operation of 2 cases of intracranial malignant tumor with hemophilia A in children, with no abnormal bleeding events. The establishment of the multi subject cooperation group before operation, good preoperative preparation, enough alternative factors, and close postoperative monitoring, are the key to the successful treatment.

Key words: Brain neoplasms, Hemophilia A, Intraoperative period, Factor Ⅷ, Child