目的：评估多个大关节置换患者的临床疗效和生活质量改善情况。方法：回顾性研究2005年至2010年间13例接受3或4个大关节置换的患者，应用SF-36生活质量评分、Harris髋关节评分、美国膝关节协会评分标准（KSS膝关节评分）对其进行术前和术后评估，并对这些患者的生活质量和关节功能改善情况进行分析。结果：SF-36生活质量评分平均值手术前后变化如下：生理功能4.17±14.43→65.83±24.76、生理职能：25.00±26.11→60.42±45.80、躯体疼痛23.83±21.41→76.88±20.89、总体健康53.33±33.87→76.67±14.67、活力50.42±17.25→71.67±16.28、社会功能29.17±33.50→73.96±33.90、情感职能22.08±35.61→77.77±41.03、精神健康53.33±25.70→82.67±14.41，术后均较术前明显提高（P<0.05）。Harris评分从术前的37.68±14.71上升至83.36±13.54；KSS临床评分（42.52±23.83→77.74±20.67）和功能评分（-2.61±22.56→65.65±30.76）也明显改善（P<0.001）。结论：多关节病变患者通过多关节置换可以明显提高生活质量，改善关节功能，但单个关节的功能较一般患者要差，并发症发生率较一般患者高。

Objective：To evaluate the effectiveness of conducting multiple arthroplasty to treat multiple joints disease in terms of quality of life (QOL) and function improvement. Methods:We compared our results with the reported results of single and dual arthroplasty to see if there is any improvement in QOL, functional scores or complications. In this study, 13 patients admitted to Department of Adult Reconstructive Surgery, Beijing Jishuitan hospital from 2005 to 2009 were included. Questionnaires SF-36 were used to evaluate the QOL. Harris hip score, American Knee Society Score (KSS) were used to evaluate the joint function. The patients were evaluated before surgery to the latest follow up. Results:SF-36 has changed as follow: physical function 4.17±14.43→65.83±24.76,  role physical 25.00±26.11→60.42±45.8, bodily pain 23.83±21.41→76.88±20.89, general health 53.33±33.87→76.67±14.67, vitality 50.42±17.25→71.67±16.28, social functioning 29.17±33.50→73.96±33.90, role emotional 22.08±35.61→77.77±41.03, mental health 53.33±25.70→82.67±14.41, which indicated that they all improved greatly after the surgery (P<0.05). Harris score increased from 37.68±14.71 before the surgery to 83.36±13.54 after the surgery. KSS has also showed sharp improvement (P<0.001) in both clinical score (42.52±23.83→77.74±20.67) and function score (-2.61±22.56→65.65±30.76).Conclusion:Multiple arthroplasty is one of the most effective methods which can markedly improve the quality of life in patients with multiple joints disease. But complications are common and joint functions are relatively poor.