Effect of radiotherapy and indomethacin together in the prevention of recurrence of ectopic ossification around the elbow after resection
Online published: 2016-04-18
目的:探讨局部小剂量单次放射治疗(放疗)加口服吲哚美辛对预防肘关节异位骨化切除术后复发的效果。方法: 2009年1月至2011年12月间对78例肘关节创伤后僵硬并肘关节异位骨化患者于肘关节松解同时行异位骨化切除。显露及切除异位骨化,于深部组织皆采用内、外侧双入路,于内侧显露并保护尺神经,之后去除内侧关节囊;近端于肱肌和肱三头肌之间进入,去除后部内侧异位骨化、后关节囊;远端于尺侧腕屈肌尺骨头与肱骨头之间去除异位骨化。外侧近端于肱三头肌下方去除后方异位骨化,于肱桡肌下方显露并去除前方异位骨化,外侧远端于肱肌下方显露并去除异位骨化。如需改善前臂旋转功能,则需将上尺桡周围异位骨化及增生斑痕切除,术中视情况决定尺神经是否前移。于异位骨化切除术前4 h内行肘关节周围局部小剂量单次放疗,放疗剂量为6~7 Gy,术后口服吲哚美辛25 mg,每日3次, 6周,术后康复以主动锻炼及主动辅助锻炼为主。78例患者中,男性46例,女性32例,平均年龄(35.8±7.9)岁(16~65岁)。按Hastings-Graham分型,术前肘关节异位骨化ⅡA型 56例, ⅡB型5例,ⅡC型 6例,Ⅲ型11例。结果: 术后随访平均26个月(24~36个月),78例患者肘关节功能改善,除1例患者外,肘关节正、侧位X线片均未见明显异位骨化复发;有1例患者术后2年随访时X线片显示异位骨化较明显,但功能正常。结论: 局部小剂量单次放疗加口服吲哚美辛对预防肘关节异位骨化切除术后复发有意义。
刘兴华 , 蒋协远 , 公茂琪 , 查晔军 . 放射治疗加口服吲哚美辛预防肘关节异位骨化切除术后的复发[J]. 北京大学学报(医学版), 2016 , 48(2) : 230 -233 . DOI: 10.3969/j.issn.1671-167X.2016.02.009
Objective:To discuss the effect of single low dose local radiotherapy and indomethacin together in the prevention of recurrence of ectopic ossification around the elbow after resection. Methods: From Jun. 2009 to Dec. 2011, we performed excision of ectopic ossification around the elbow in 78 stiff elbows. For each case, we used both medial and lateral approaches, and we performed both anterior and posterior capsulectomies and removal of ectopic ossification. In the lateral approach, we started proximally, the lateral supracondylar ridge of the humerus was exposed from the interval between extensor carpi radialis longus (ECRL) and triceps, and then distally passed the interval between ECRL and extensor carpi radialis brevis (ECRB). With the medial approach, after releasing the ulnar nerve, the pronator teres muscle origin was reflected from the medial epicondyle, and then the common flexor-pronator tendon was split longitudinally distally and the brachalis and the anterior portion of the flexor-pronator group were dissected off the anterior humerus. If there was forearm rotation dysfunction, we used extensive lateral approach, the anconeus muscle was reflected from the ulna and the scar tissue and ectopic ossification around the proximal radioulnar joint were resected. The important structures, such as the lateral ulnar collateral ligament (LUCL) and the anterior part of the medial collateral ligament (AMCL), should be carefully protected, because they were important for the elbow stability. Anterior transposition of the ulnar nerve depended on the patients’ condition. We performed low dose radiotherapy 4 hours before operation, and we used indomethacin for 6 weeks after operation. In these patients, there were 46 males and 32 females, whose age averaged (35.8±7.9) years (16-65 years). According to Hastings-Graham classification, there were 56 ⅡA, 5 ⅡB, 6 ⅡC and 11 Ⅲ before operation. Results: We followed up these patients for 26 months with an average of 24-36 months, all the patients improved their elbow function, and no recurrence of ectopic ossification appeared except for 1 patient. For this patient, his elbow function was excellent, and according to Hastings-Graham classification, his ectopic ossification was of type Ⅰ. Conclusion: Single low dose local radiotherapy and indomethacin together are effective in the prevention of recurrence of ectopic ossification around the elbow after excision.
Key words: Elbow joint; Ossification, heterotopic; Radiotherapy; Indomethacin
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