目的： 评价伴错牙合畸形的侵袭性牙周炎（aggressive periodontitis，AgP）患者行牙周正畸联合治疗的临床疗效及安全性。方法： 纳入25名就诊于北京大学口腔医院牙周科并完成牙周正畸治疗的AgP患者，回顾性评价初诊（T0）、正畸治疗前（T1）、正畸治疗完成后（T2）的探诊深度（probing depth，PD）、出血指数（bleeding index，BI）、探诊后出血比率（percentage of sites with bleeding on probing，BOP%）， 通过根尖片评价正畸前后剩余牙槽骨高度（residual alveolar bone height，RBH）的变化及牙根吸收发生状况。结果： （1）在牙周治疗后、正畸治疗前（T1）及正畸治疗完成后（T2），PD、BI、BOP%以及PD>3 mm位点的百分比均有显著降低（P<0.001）。（2）T0时全口RBH均值为68.37%±15.60%，牙周正畸治疗后RBH为70.27%±14.23%，差异有统计学意义，其中上切牙［T0为58.79%±16.71%，T2为65.54%（55.74%，78.13%）］、上尖牙［T0为77.62%（66.06%，87.17%），T2为79.57%（69.75%，86.52%）］及上磨牙［T0为74.30%（61.69%，84.45%），T2为76.76%（68.12%，85.09%）］在正畸治疗后RBH增高明显（P<0.05）。（3）正畸治疗后人均有23.94%±13.45%的牙发生牙根吸收，其中以下切牙及上切牙的发生率最高，总发生率分别为68.48%和65.31%。结论： 伴错牙合畸形的AgP患者，在规范的牙周治疗后，正畸治疗不会引起牙周炎症加重或牙槽骨吸收；约2/3的上、下切牙可发生轻度的牙根吸收。

Objective： To evaluate the clinical effect and safety of periodontal-orthodontic treatment in patients with aggressive periodontitis (AgP) and malocclusion. Methods: A retrospective analysis was conducted in 25 AgP patients, who had received periodontal-orthodontic treatment in Peking University School and Hospital of Stomatology. Clinical indexes, including probing depth (PD), bleeding index (BI) and percentage of sites with bleeding on probing (BOP%) were evaluated at three time points: Baseline (T0); active periodontal treatment finished and before orthodontic treatment (T1); and after orthodontic treatment (T2). Also changes of ratio of the residual alveolar bone height (RBH) and the occurrence of root resorption were evaluated by periapical radiographs. Results: (1) Compared with T0, all the clinical parameters including PD, BI, BOP% and percentage of sites with PD>3 mm were significantly improved (P<0.001). (2) Significant difference was observed in the average RBH between T0 (68.37%±15.60% and T2 (70.27%±14.23%). RBH in upper incisors ［(58.79%±16.71% at T0, 65.54% (55.74%, 78.13%) at T2］, upper canines ［77.62% (66.06%, 87-17%) at T0, 79.57% (69.75%, 86.52%) at T2］ and upper molars ［74.30% (61-69%, 84-45%) at T0, 76.76% (68.12%, 85.09%) at T2］ showed significant increase (P<0.05). (3) After orthodontic treatment, varying degrees of root resorption occurred in (23.94%±13.45%) of teeth per capita, among which the lower and upper incisors showed the highest incidence (68.48% and 65.31% in homogeneous teeth, respectively). Conclusion: After active periodontal treatment, orthodontic treatment in AgP patients had not aggravated inflammation and alveolar bone resorption; root resorption occurred in two-thirds of incisors approximately.