目的：观察罹患重度牙周炎磨牙拔牙位点同期植入Bio-Oss并覆盖 Bio-Gide-胶原膜愈合6个月后组织形态学特点和成骨效果。方法： 6名研究对象共6颗罹患牙周病变磨牙拔除后即刻在拔牙窝内植入Bio-Oss-颗粒覆盖Bio-Gide-胶原膜。术后6个月，翻瓣再进入,在位点保存区取一块直径2.8 mm、长度6.0 mm的圆柱状骨组织,制作甲苯胺蓝染色的硬组织切片,进行组织学检查和骨组织形态计量学分析。结果：骨组织形态计量学结果显示平均11.54%（0~28.40%）新生骨形成和35.04%（13.92%~50.87%）Bio-Oss-颗粒残留，其中20.13%（0~48.50%）Bio-Oss-颗粒与新生骨组织直接接触，79.87%（51.50%~100.00%）颗粒被结缔组织包裹；上颌位点新生骨和Bio-Oss-颗粒百分比均较下颌位点少。结论： 组织学检查发现罹患重度牙周炎磨牙拔牙窝内植入Bio-Oss-并覆盖 Bio-Gide-胶原膜愈合6个月后有新骨形成，仍有较多 Bio-Oss-颗粒残留。

Objective： To evaluate bone formation in human extraction sockets with absorbed surroun-ding walls augmented with Bio-Oss-and Bio-Gide-after a 6-month healing period by histologic and histomorphometric analyses. Methods: Six fresh molar tooth extraction sockets in 6 patients who required periodontally compromised moral tooth extraction were included in this study. The six fresh extraction sockets were grafted with Bio-Oss-particle covered with Bio-Gide^R. The 2.8 mm×6.0 mm cylindric bone specimens were taken from the graft sites with aid of stent 6 months after the surgery. Histologic and histomorphometric analyses were performed. Results: The histological results showed Bio-Oss-particles were easily distinguished from the newly formed bone, small amounts of new bone were formed among the Bio-Oss-particles, large amounts of connective tissue were found. Intimate contact between the newly formed bone and the small part of Bio-Oss-particles was present. All the biopsy cylinders measurement demonstrated a high inter-individual variability in the percentage of the bone, connective tissues and Bio-Oss-particles. The new bone occupied 11.54% (0-28.40%) of the total area; the connective tissues were 53.42% (34.08%-74.59%) and the Bio-Oss-particles were 35.04% (13.92%-50.87%). The percentage of the particles, which were in contact with bone tissues, amounted to 20.13% (0-48.50%). Conclusion: Sites grafted with Bio-Oss-particles covered with Bio-Gide-were comprised of connective tissues and small amounts of newly formed bone surrounding the graft particles.