目的: 采用腺体实体体外检测法测量正常下颌下腺的质量和体积,探讨影响下颌下腺质量和体积可能的相关因素,并与CT容积重建法测量值做比较,评估两种检测方法的一致性。方法: 选择2019年5月至2020年1月在北京大学口腔医院因口腔癌接受选择性颈淋巴结清扫术且术后组织病理学证实下颌下腺正常的患者,术前CT扫描图像通过CT容积重建法测量下颌下腺体积;术中颈淋巴结清扫标本离体后沿包膜完整游离下颌下腺,使用一体式无菌测量装置测量下颌下腺的质量和体积,进行两种测量方法所得下颌下腺体积的比较。参照中华医学会老年医学会和世界卫生组织(2000年)标准对受试者进行年龄分组,测量不同性别和年龄组正常下颌下腺质量和体积,分析年龄、性别、身高、体质量、体重指数等因素与下颌下腺质量和体积的相关性。结果: 共完成220例受试者正常下颌下腺质量和体积的腺体实体体外检测,下颌下腺平均质量为(11.69±2.45) g,平均体积为(11.55±2.41) cm³。CT容积重建法测得的下颌下腺体积为实体体外检测法所得体积的70%~82%,两种方法测量结果的相关系数为0.976(P<0.05)。青年组、中年组、年轻老年及老年组中,男性下颌下腺的质量和体积明显高于女性(P<0.05),青少年组不同性别间差异无统计学意义(P>0.05)。下颌下腺的质量和体积与身高呈中等强度的正相关(P<0.05),与体质量呈弱正相关(P<0.05),与体重指数无关(P>0.05)。年轻老年及老年组女性的下颌下腺质量和体积显著低于其他三组(P<0.05)。结论: 腺体实体体外检测法可以精确检测下颌下腺的质量和体积,本研究建立了不同性别和年龄组正常下颌下腺质量和体积的参考值。CT容积重建法测量的下颌下腺体积为腺体实体体外检测法的70%~82%,两种方法测量结果趋势一致,拟合度好。下颌下腺的质量和体积与年龄、性别、身高和体质量具有相关性。

Objective: To measure the weight and volume of normal submandibular gland by in vitro detection of glandular body, to compare with the measurement values of CT volume rendering to evaluate the consistency of the two methods, and to explore the related factors affecting the weight and volume of the submandibular gland.Methods: The patients who underwent neck dissection due to oral cancer and were confirmed with normal submandibular gland by postoperative histopathology in Peking University School and Hospital of Stomatology from May 2019 to January 2020 were collected in this study and divi-ded into 4 groups according to the age standards raised by the Society of Geriatrics Chinese Medical Association and WHO (2000) age standards. The submandibular gland was carefully dissected along with the capsule immediately after neck dissection. The weight and volume of submandibular gland were accurately measured by an integrated aseptic measuring device. The volume of submandibular gland was measured by CT volume rendering before operation and the consistency of the two methods was evaluated. The 95% confidence interval of the weight and volume of submandibular gland in the different groups of Chinese people, which were divided by gender and age, were calculated, and the correlation with age, gender, height, weight, body mass index (BMI) and other factors was analyzed.Results: The weight and vo-lume of submandibular gland were measured in 220 subjects. The average weight and volume of submandibular gland were (11.69±2.45) g and (11.55±2.41) cm³ respectively. The volume of submandibular gland measured by CT volume rendering ranged from 70% to 82% of that measured by in vitro detection of glandular body, and the correlation coefficient between the two methods was 0.976 (P<0.05). The gender difference of weight and volume of submandibular gland existed in the groups of youth, middle-aged, young elderly and elderly groups, the values of males were obviously higher than those of females (P<0.05). There was no gender difference of weight and volume of submandibular gland in the adolescent group (P>0.05). The weight and volume of submandibular gland had a strong positive correlation with body height (P<0.05), a weak positive correlation with body weight (P<0.05), and no correlation with BMI (P>0.05). The female’s weight and volume of submandibular gland in the young elderly and elderly groups were significantly lower than those in the other three groups (P<0.05). Conclusion: The normal reference range of the weight and volume of submandibular gland in vitro were established in different age and gender groups of Chinese people. The volume of submandibular gland mea-sured by CT volume rendering was 70%-82% of that measured by in vitro detection of glandular body. The results of the two methods had a high degree of consistency. The weight and volume of submandibular gland were related to age, gender, body height and body weight.