基因多态性对中国汉族女性乳腺癌遗传易感性的影响

方伟岗; 田新霞; 解云涛

doi:10.19723/j.issn.1671-167X.2022.05.007

北京大学学报（医学版） >

2022 , Vol. 54 >Issue 5: 822 - 828

DOI: https://doi.org/10.19723/j.issn.1671-167X.2022.05.007

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基因多态性对中国汉族女性乳腺癌遗传易感性的影响

方伟岗 ,
田新霞 ,
解云涛

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¹ 北京大学基础医学院病理学系，北京 100191
² 北京大学第三医院病理科，北京 100191
³ 北京大学肿瘤医院家族遗传性肿瘤中心，北京 100142

方伟岗，病理学博士，教授，博士生导师，北京大学临床研究所所长。历任中华医学会病理学分会常务委员、国际病理学会中国分部主席、吴阶平医学基金会病理学部副主任委员、中国研究型医院学会移动医疗专业委员会主任委员、中国抗癌协会肿瘤转移专业委员会主任委员、中华医学会医学科研管理学分会主任委员、中华医学科技奖评审委员会委员、华夏医学科技奖理事会常务理事、教育部科学技术委员会第五届学部委员等，并担任多个国内外期刊的副主编或编委，受聘澳大利亚Monash大学客座教授。主持国家重点研发计划、国家重点基础研究发展计划(973计划)课题、国家自然科学基金等30余项国家/省部级研究课题。研究成果以第一或责任作者在国内外杂志发表论文80余篇(其中SCI论文30余篇)，获得教育部“跨世纪优秀人才”“北京青年五四奖章”“卫生部有突出贡献中青年专家”等荣誉，享受国务院特殊津贴。
从事肿瘤转移机制研究30余年，在国际上首次发现ATP能够抑制激素非依赖型人前列腺癌细胞的体外生长，发现ATP对肿瘤细胞的作用具有多样性，首次提出肿瘤微环境中ATP是重要促侵袭因子的假说并予以证实，为肿瘤侵袭发生的机制及调控提供了新的依据。运用单核苷酸多态性及单体型相关性分析对较大样本量中国汉族妇女中某些热点基因的遗传学多态性与乳腺癌易感性、肿瘤演进及生存的关系进行了研究，为相关领域的研究提供了有益的数据

收稿日期: 2022-06-25

网络出版日期: 2022-10-14

基金资助

国家自然科学基金(81872382);国家自然科学基金(81672790);国家自然科学基金(81171961)

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方伟岗 , 田新霞 , 解云涛 . 基因多态性对中国汉族女性乳腺癌遗传易感性的影响[J]. 北京大学学报（医学版）, 2022 , 54(5) : 822 -828 . DOI: 10.19723/j.issn.1671-167X.2022.05.007

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