Journal of Peking University(Health Sciences) ›› 2014, Vol. 46 ›› Issue (3): 395-399.

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Effects of TiO2 nanoparticles on antioxidant function and element content of liver and kidney tissues in young and adult rats

WANG Yun, CHEN Zhang-ian, BA Te, PU Ji, CUI Xiao-ing, JIA Guang△   

  1. (Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, Beijing 100191, China)
  • Online:2014-06-18 Published:2014-06-18

Abstract: Objective:To compare the effect of TiO2 nanoparticles on antioxidant function and element content of liver and kidney tissues in young and adult rats. Methods: Forty-ight SD male rats, half in 4-eek (youth) old and half in 9-eek (adult) old rats, were randomly divided into 8 groups, which were exposed to TiO2 nanoparticles [(75±15) nm, anatase] through intragastric administration at 0, 10, 50 and 200 mg/kg body weight every day for 30 days. The liver and kidney tissues were collected for antioxidant function and element content analysis. Results: 200 mg/kg TiO2 nanoparticles exposure significantly increased the liver total superoxide dismutase (T-OD) activity and the kidney reduced glutathione (GSH)/oxidized glutathione (GSSG) ratios in young rats, and significantly decreased the liver Mo, Co, Mn and P contents and the kidney Rb and Na contents in young rats. 200 mg/kg TiO2 nanoparticles exposure significantly increased GSH/GSSG ratios and Rb contents and decreased Na contents in the liver of adult rats. No significantly difference was found in antioxidant indexes and elements content in the kidney of adult rats between three experimental groups and control group. Conclusion: TiO2 nanoparticles can enhance the antioxidant capacity and decrease the elements content in rat liver and kidney tissues. The liver is the more sensitive target organ and the young animals are more susceptible to TiO2 nanoparticles toxicity by the oral routes.

Key words: Nanoparticles, Titanium dioxide, Safety, Hepatotoxicity, Nephrotoxicity

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