引导性组织再生术对浓缩生长因子联合植骨术治疗下颌磨牙Ⅱ度根分叉病变临床效果的影响

doi:10.19723/j.issn.1671-167X.2020.02.024

Abstract

Abstract:

Objective: Tissues loss due to periodontal disease is typically treated by a variety of rege-nerative treatment modalities, including bone grafts, guided tissue regeneration (GTR) and growth factors, to reform the supporting tissues of teeth. Concentrated growth factors (CGF) are produced by centrifuging blood samples at alternating and controlled speeds using a special centrifuge. The purpose of this study was to evaluate whether GTR could improve the effect of CGF combined with bone graft in the treatment of classⅡ furcations of mandibular molars.Methods: In the present study, thirty-five classⅡ furcation involvements were included and randomly divided into two groups. The experimental group (n=17) accepted GTR combined with CGF and bone graft therapy, and the controlled group (n=18) accepted CGF combined with bone graft therapy. The clinical examinations and cone beam computed tomography (CBCT) were performed at baseline and 1 year post-surgery. Comparisons of clinical and CBCT data before and after operation between the experimental group and the control group were made.Results: The clinical and CBCT data of both groups were not statistically different at baseline (P>0.05). At the end of 1 year post-surgery, the clinical parameters of both groups were significantly improved (P<0.001). The probing depths of the experimental group were (4.81±1.95) mm and (3.56±1.94) mm, respectively, significantly higher than the changes of the control group (P<0.001). The vertical and horizontal attachment gains of the experimental group were (4.11±1.98) mm and (3.84±1.68) mm, respectively, significantly higher than the changes of the control group (P<0.001). At the end of 1 year post-surgery, the experimental group showed significantly higher bone gain at vertical and horizontal directions compared with those of the control group: (3.84±1.68) and (3.88±2.12) mm, respectively (P<0.001).Conclusion: Within the limitation of the present study, GTR showed positive role in the effect of CGF combined with bone graft in the treatment of classⅡ furcation involvements of mandibular molars.

Key words: Concentrated growth factors, Furcation involvement, Bone grafting, Guided tissue regeneration

CLC Number:

R781.3

Fei LI,Jing QIAO,Jin-yu DUAN,Yong ZHANG,Xiu-jing WANG. Effect of concentrated growth factors combined with guided tissue regeneration in treatment of classⅡ furcation involvements of mandibular molars[J].Journal of Peking University (Health Sciences), 2020, 52(2): 346-352.

Figures/Tables 12

Table 1

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Figure 2

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Table 2

Clinical measurements of experimental and controlled group at baseline and 1 year post-surgery"

Items	Experimental group	Controlled group
PPD/mm, $\bar{x}±s$
Baseline	7.86±2.47	7.73±2.15
1 year post-surgery	3.05±1.33^*	4.17±2.09^*
PPD reduction	4.81±1.95^#	3.56±1.94
REC/mm, $\bar{x}±s$
Baseline	1.42±0.87	1.48±0.69
1 year post-surgery	2.12±1.05^*	2.14±1.03^*
REC increase	0.70±0.63	0.66±0.62
CAL-V/mm, $\bar{x}±s$
Baseline	9.28±2.65	9.21±2.51
1 year post-surgery	5.17±1.48^*	6.31±2.45^*
Vertical attachment gain	4.11±1.98^#	2.90±2.01
CAL-H/mm, $\bar{x}±s$
Baseline	6.08±2.31	6.05±2.44
1 year post-surgery	2.24±1.29^*	3.35±1.67^*
Horizontal attachment gain	3.84±1.68^#	2.70±1.47

Table 2

Table 3

The CBCT data of experimental and controlled group at baseline and 1 year post-surgery"

Items	Experimental group	Controlled group
BL-V/mm, $\bar{x}±s$
Baseline	6.01±2.34	6.04±2.58
1 year post-surgery	2.17±1.49^*	3.15±1.37^*
Vertical radiograph bone gain	3.84±1.68^#	2.89±2.03
BL-H/mm, $\bar{x}±s$
Baseline	6.75±2.44	6.73±2.57
1 year post-surgery	2.87±2.02^*	4.21±2.07^*
Horizontal radiograph bone gain	3.88±2.12^#	2.52±2.26

Table 3

References 24

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Group	Number of teeth	Furcation location		Total
Group	Number of teeth	Buccal	Lingual	Total
Experimental group	11	9	8	17
Controlled group	11	9	9	18

Effect of concentrated growth factors combined with guided tissue regeneration in treatment of classⅡ furcation involvements of mandibular molars

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