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Journal of Peking University (Health Sciences) ›› 2025, Vol. 57 ›› Issue (5): 864-867. doi: 10.19723/j.issn.1671-167X.2025.05.009

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Development and dissemination of precision medicine approaches in gastric cancer management

Zhemin LI1, Jiafu JI2,*(), Guoxin LI3, Ziyu LI1, Zhaode BU1, Xiangyu GAO2, Di DONG4, Lei TANG5, Xiaofang XING6, Shuqin JIA7, Ting GUO8, Lianhai ZHANG1, Fei SHAN1, Xin JI1, Anqiang WANG1   

  1. 1. Gastrointestinal Cancer Center, Peking University Cancer Hospital & Institute, Beijing 100142, China
    2. Gastrointestinal Cancer Center, Peking University Cancer Hospital & Institute, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing 100142, China
    3. Department of Gastrointestinal Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China
    4. CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
    5. Department of Medical Imaging, Peking University Cancer Hospital & Institute, Beijing 100142, China
    6. Gastrointestinal Cancer Translational Research Laboratory, Peking University Cancer Hospital & Institute, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing 100142, China
    7. Molecular Diagnostic Center, Peking University Cancer Hospital & Institute, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing 100142, China
    8. Gastrointestinal Cancer Translational Research Laboratory, Peking University Cancer Hospital & Institute, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Beijing 100142, China
  • Received:2025-08-01 Online:2025-10-18 Published:2025-08-28
  • Contact: Jiafu JI
  • Supported by:
    the National Natural Science Foundation(92259302); the National Natural Science Foundation(31870805); the National Natural Science Foundation(U20A20371); the Beijing Hospitals Authority Talent Plan(DFL20181103); the Beijing Hospitals Authority Talent Plan(SML20151001); the Beijing Municipal Science and Technology Plan Projects(D171100006517000); the Beijing Municipal Science and Technology Plan Projects(D171100006517004)

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Abstract: Gastric cancer is a high-incidence malignancy that poses a serious threat to public health in China, ranking among the top three cancers in both incidence and mortality. The majority of patients are diagnosed at an advanced stage, resulting in limited treatment options and poor prognosis. To address key challenges in gastric cancer diagnosis and treatment, a research team led by Professor Jiafu Ji at Peking University Cancer Hospital has focused on the project "Development and Dissemination of Precision Medicine Approaches in Gastric Cancer Management". Through a series of high-quality multicenter clinical studies, the team established a set of new international standards in perioperative treatment, individua-lized drug selection, intelligent noninvasive diagnostics, and novel immunotherapy strategies. These advances have significantly improved treatment efficacy and reduced surgical trauma, achieving key technological breakthroughs in diagnosis, therapy, and mechanistic understanding, and systematically enhancing outcomes for gastric cancer patients. The project ' s findings had a broad international impact, including hosting China ' s first International Gastric Cancer Congress. Through nationwide dissemination, they have promoted the development of precision diagnosis and treatment of gastric cancer as a discipline, and led the formulation of the National Health Commission's guidelines for gastric cancer diagnosis and treatment. In recognition of its achievements, the project was awarded the First Prize of the 2024 Chinese Medical Science and Technology Award.

Key words: Gastric cancer, Neoadjuvant chemotherapy, Laparoscopic surgery, Artificial intelligence, Immunotherapy

CLC Number: 

  • R735.2
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